PCIDB

KNApSAcK Metabolite C00001163

Metabolite

KNApSAcK Entry

id C00001163
Name Glycerol
CAS RN 56-81-5
Standard InChI InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
Standard InChI (Main Layer) InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

Cluster

Phytochemical cluster
KCF-S cluster No. 5926

Link

ChEMBL

By standard InChI CHEMBL692
By standard InChI Main Layer CHEMBL692

KEGG

By LinkDB C00116

CTD

By CAS RN D005990

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10323 Acrosin S1A CHEMBL692 CHEMBL639765 (1)
0 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme CHEMBL692 CHEMBL1002981 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL692 CHEMBL1794524 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL692 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL692 CHEMBL1794561 (1)
3 / 1
P08183 Multidrug resistance protein 1 drug CHEMBL692 CHEMBL2076221 (1)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL692 CHEMBL1614458 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL692 CHEMBL2114890 (1)
0 / 0

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
D005990 335 APOA1
apolipoprotein A-I Glycerol analog promotes the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] increases expression
/ increases reaction
protein 19013290
D005990 89872 AQP10
AQPA_HUMAN
aquaporin 10 AQP10 protein results in increased uptake of Glycerol increases uptake
protein 12084581
D005990 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) Glycerol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] decreases reaction
/ increases degradation
protein 9143349
D005990 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) Glycerol results in increased expression of HMOX1 mRNA increases expression
mRNA 20491607
D005990 4489 MT1A
MT1
MT1S
MTC
metallothionein 1A Glycerol results in increased expression of MT1A mRNA increases expression
mRNA 20491607
D005990 4502 MT2A
MT2
metallothionein 2A Glycerol results in increased expression of MT2A mRNA increases expression
mRNA 20491607
D005990 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Glycerol results in decreased expression of MYC mRNA decreases expression
mRNA 2558650
D005990 4878 NPPA
ANF
ANP
ATFB6
CDD-ANF
PND
natriuretic peptide A Glycerol results in increased expression of NPPA protein increases expression
protein 2177369
D005990 5443 POMC
ACTH
CLIP
LPH
MSH
NPP
POC
proopiomelanocortin POMC protein alternative form results in increased secretion of Glycerol increases secretion
protein 8429757
D005990 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Glycerol results in increased activity of TP53 protein mutant form increases activity
protein 15975526

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (11)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)

Diseases related to CTD interactions

18 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 D005990 Acute Kidney Injury marker/mechanism
1134612
1324513
1751788
2087497
4644892
6822758
11485932
12021577
16820301
22021999
22613216
D001002 D005990 Anuria marker/mechanism
1751788
D004195 D005990 Disease Models, Animal marker/mechanism
4644892
D015812 D005990 Glaucoma, Angle-Closure therapeutic
5013835
D006947 D005990 Hyperkalemia marker/mechanism
11046231
D007010 D005990 Hyponatremia therapeutic
3919450
D007177 D005990 Inappropriate ADH Syndrome therapeutic
3919450
D007674 D005990 Kidney Diseases marker/mechanism
19452295
D007683 D005990 Kidney Tubular Necrosis, Acute marker/mechanism
8583688
D056784 D005990 Leukoencephalopathies marker/mechanism
16691149
D017202 D005990 Myocardial Ischemia marker/mechanism
531484
D009212 D005990 Myoglobinuria marker/mechanism
10362817
D009336 D005990 Necrosis marker/mechanism
20299303
D009393 D005990 Nephritis marker/mechanism
16272714
D051437 D005990 Renal Insufficiency marker/mechanism
16272714
D012206 D005990 Rhabdomyolysis marker/mechanism
22021999
D020521 D005990 Stroke therapeutic
2177369
D017180 D005990 Tachycardia, Ventricular marker/mechanism
11046231