Species

KNApSAcK Entry

Organism name Pimpinella anisum L.
Genus Pimpinella
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pimpinella anisum
Linked NCBI taxonomy ID 271192
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (16)

Species Activity
Pimpinella anisum L. Abortifacient
Pimpinella anisum L. Allergenic
Pimpinella anisum L. Analgesic
Pimpinella anisum L. Antibacterial
Pimpinella anisum L. Anticonvulsant
Pimpinella anisum L. Antiseptic
Pimpinella anisum L. Antispasmodic
Pimpinella anisum L. Antiviral
Pimpinella anisum L. Aperitif
Pimpinella anisum L. Aphrodisiac
Pimpinella anisum L. Carminative
Pimpinella anisum L. Collyrium
Pimpinella anisum L. Dentifrice
Pimpinella anisum L. Diaphoretic
Pimpinella anisum L. Emmenagogue
Pimpinella anisum L. Sedative

Metabolite list (29)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037992 External link 512 Viridoside
No. 45 No. 72
C00037912 External link 512 threo-1'-(4-Hydroxyphenyl)propane 1',2'-diol 4-O-beta-D-glucopyranoside
No. 45 No. 72
C00036335 External link 512 (1'S,2'R)-1'-(4-Hydroxyphenyl)propane-1',2'-diol 2'-O-beta-D-glucopyranoside
/ (-)-(1'S,2'R)-1'-(4-Hydroxyphenyl)propane-1',2'-diol 2'-O-beta-D-glucopyranoside
No. 45 No. 72
C00019029 External link 512 Tachioside
/ 3-Methoxy-4-hydroxyphenyl-beta-D-glucopyranoside
CHEMBL1077078
No. 45 No. 72
C00019030 External link 512 Isotachioside
/ Methoxy-hydroquinone-1-O-beta-D-glucopyranoside
/ 4-Hydroxy-2-methoxyphenyl-beta-D-Glucopyranoside
No. 45 No. 72
C00029534 External link 512 4-Hydroxybenzyl beta-D-glucopyranoside
No. 45 No. 72
C00029812 External link 512 Benzyl beta-D-glucopyranoside
/ (-)-Benzyl-O-beta-D-glucopyranoside
CHEMBL1170453
CHEMBL2336738
C410942
No. 45 No. 72
C00036331 External link 512 (1'R,2'S)-1'-(4-Hydroxyphenyl)propane-1',2'-diol 2'-O-beta-D-glucopyranoside
No. 45 No. 72
C00030508 External link 512 Icariside D2
No. 45 No. 72
C00036327 External link 512 (1'R,2'R)-1'-(4-Hydroxyphenyl)propane-1',2'-diol 2'-O-D-glucopyranoside
No. 45 No. 72
C00036329 External link 512 (1'R,2'R)-Guaiacyl glycerol 4-O-beta-D-glucopyranoside
/ (-)-(1'R,2'R)-Guaiacyl glycerol 4-O-beta-D-glucopyranoside
No. 45 No. 72
C00036358 External link 512 (Z)-4-Hydroxy-cinnamyl alcohol 4-O-beta-D-glucopyranoside
No. 45 No. 72
C00037117 External link 512 erythro-1'-(4-Hydroxyphenyl)propane-1',2'-diol 4-O-beta-D-glucopyranoside
No. 45 No. 72
C00036336 External link 512 (1'S,2'S)-Anethole glycol 2'-O-beta-D-glucopyranoside
/ (+)-(1'S,2'S)-Anethole glycol 2'-O-beta-D-glucopyranoside
No. 45 No. 72
C00030506 External link 512 Icariside B2
/ (-)-Icariside B2
No. 153
C00037270 External link 512 Hexane-1,5-diol 1-O-beta-D-glucopyranoside
/ (-)-Hexane-1,5-diol 1-O-beta-D-glucopyranoside
No. 258 No. 73
C00031877 External link 512 Icariside F2
/ Benzyl beta-D-Apiofuranosyl-(1->6)-O-beta-D-glucopyranoside
No. 267
C00031876 External link 512 Icariside D1
No. 267
C00037294 External link 512 Icariside B1
/ (-)-Icariside B1
No. 316
C00001122 External link 512 Glucose
/ D-Glucose
/ alpha-D-Glucose
CHEMBL300520
CHEMBL98182
CHEMBL103010
CHEMBL423707
CHEMBL195923
CHEMBL469448
CHEMBL1222152
CHEMBL1222250
CHEMBL1233058
CHEMBL1453070
CHEMBL1519430
CHEMBL1614854
CHEMBL1873035
CHEMBL2093058
CHEMBL2115552
26 / 15 / 15 No. 1283
C00033848 External link 512 Fructose
/ D-Fructose
/ D-(-)-Fructose
CHEMBL23894
CHEMBL1869413
9 / 4 / 3 No. 1614
C00037913 External link 512 threo-Anethole glycol
CHEMBL553164
No. 1736
C00037118 External link 512 erythro-Anethole glycol
CHEMBL553164
No. 1736
C00036328 External link 512 (1'R,2'R)-Guaiacyl glycerol
/ (-)-(1'R,2'R)-Guaiacyl glycerol
CHEMBL1078124
No. 1736
C00036428 External link 512 1-Deoxythreitol
No. 2923
C00001151 External link 512 Sucrose
/ (+)-Sucrose
CHEMBL253582
CHEMBL1976550
D013395
1 / 0 / 0 4 / 10 No. 3949
C00035904 External link 512 2-C-Methyl-D-erythritol
No. 4667
C00001163 External link 512 Glycerol
CHEMBL692
D005990
8 / 15 / 11 10 / 18 No. 5926
C00036483 External link 512 2-Deoxy-D-ribono-1,4-lactone
CHEMBL98888
CHEMBL97916
C056405
1 / 0 / 0 No. 7920

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10323 Acrosin S1A C00001122 C00001163 C00033848 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001122 C00033848 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001122 C00001163 3 / 1
P07306 Asialoglycoprotein receptor 1 Membrane receptor C00001122 0 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00001163 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001163 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00033848 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001163 11 / 10
P11226 Mannose-binding protein C Unclassified protein C00001122 2 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein C00033848 2 / 0
P02768 Serum albumin Secreted protein C00001151 0 / 0
P08183 Multidrug resistance protein 1 drug C00001163 1 / 0
P09382 Galectin-1 Other cytosolic protein C00001122 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00033848 2 / 3
P11216 Glycogen phosphorylase, brain form Enzyme C00001122 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001163 0 / 0
P39748 Flap endonuclease 1 Enzyme C00033848 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001122 0 / 0
O75496 Geminin Unclassified protein C00033848 0 / 0
P15121 Aldose reductase Enzyme C00001122 0 / 0
Q9NNX6 CD209 antigen Unclassified protein C00001122 2 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00001122 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001122 0 / 0
P43116 Prostaglandin E2 receptor EP2 subtype Prostanoid receptor C00036483 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00033848 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001122 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001163 0 / 0
Q6P4F1 Alpha-(1,3)-fucosyltransferase 10 Enzyme C00001122 0 / 0
P17931 Galectin-3 Other cytosolic protein C00001122 0 / 1
P11217 Glycogen phosphorylase, muscle form Enzyme C00001122 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001122 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001122 1 / 0
O00255 Menin Unclassified protein C00001122 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001122 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00033848 0 / 0
Q9UJ71 C-type lectin domain family 4 member K Unclassified protein C00001122 1 / 0
P22897 Macrophage mannose receptor 1 Unclassified protein C00001122 0 / 0
Q8WTT0 C-type lectin domain family 4 member C Unclassified protein C00001122 0 / 0
Q6EIG7 C-type lectin domain family 6 member A Unclassified protein C00001122 0 / 0
P35247 Pulmonary surfactant-associated protein D Unclassified protein C00001122 0 / 0
Q9H2X3 C-type lectin domain family 4 member M Unclassified protein C00001122 0 / 0

14 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
335 APOA1 apolipoprotein A-I C00001163
89872 AQP10, AQPA_HUMAN aquaporin 10 C00001163
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001163
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00001163
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00001163
4502 MT2A, MT2 metallothionein 2A C00001163
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00001163
4878 NPPA, ANF, ANP, ATFB6, CDD-ANF, PND natriuretic peptide A C00001163
5443 POMC, ACTH, CLIP, LPH, MSH, NPP, POC proopiomelanocortin C00001163
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001163
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001151
55630 SLC39A4, AEZ, AWMS2, ZIP4 solute carrier family 39 (zinc transporter), member 4 C00001151
80834 TAS1R2, GPR71, T1R2, TR2 taste receptor, type 1, member 2 C00001151
83756 TAS1R3, T1R3 taste receptor, type 1, member 3 C00001151

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#613393 Birbeck granule deficiency Q9UJ71
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614371 Dengue virus, susceptibility to Q9NNX6
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#612219 Ewing sarcoma; es P11308
#137800 Glioma susceptibility 1; glm1 O75874
#232600 Glycogen storage disease v P11217
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#610424 Hepatitis b virus, susceptibility to P11226
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614372 Mannose-binding protein deficiency P11226
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
Q9NNX6
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00069 Glycogen storage diseases (GSD) P11217 (related)
H00105 Mannose-binding lectin pathway component defects P11226 (related)
H00342 Tuberculosis P11226 (related)
P11473 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00032 Thyroid cancer P17931 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

28 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00001163
D001002 Anuria C00001163
D004195 Disease Models, Animal C00001163
D015812 Glaucoma, Angle-Closure C00001163
D006947 Hyperkalemia C00001163
D007010 Hyponatremia C00001163
D007177 Inappropriate ADH Syndrome C00001163
D007674 Kidney Diseases C00001163
D007683 Kidney Tubular Necrosis, Acute C00001163
D056784 Leukoencephalopathies C00001163
D017202 Myocardial Ischemia C00001163
D009212 Myoglobinuria C00001163
D009336 Necrosis C00001163
D009393 Nephritis C00001163
D051437 Renal Insufficiency C00001163
D012206 Rhabdomyolysis C00001163
D020521 Stroke C00001163
D017180 Tachycardia, Ventricular C00001163
D019969 Amphetamine-Related Disorders C00001151
D018149 Glucose Intolerance C00001151
D006461 Hemolysis C00001151
D006946 Hyperinsulinism C00001151
D006948 Hyperkinesis C00001151
D006973 Hypertension C00001151
D007333 Insulin Resistance C00001151
D009401 Nephrosis C00001151
C541083 Non-alcoholic Fatty Liver Disease C00001151
D019966 Substance-Related Disorders C00001151