PCIDB

KNApSAcK Metabolite C00001205

Metabolite

KNApSAcK Entry

id C00001205
Name Succinic acid
CAS RN 110-15-6
Standard InChI InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
Standard InChI (Main Layer) InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

Cluster

Phytochemical cluster
KCF-S cluster No. 5377

Link

ChEMBL

By standard InChI CHEMBL576
By standard InChI Main Layer CHEMBL576

KEGG

By LinkDB C00042

CTD

By CAS RN D019802

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16798 NADP-dependent malic enzyme, mitochondrial Enzyme CHEMBL576 CHEMBL1053226 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL576 CHEMBL1614544 (1)
11 / 10
Q9GZT9 Egl nine homolog 1 Enzyme CHEMBL576 CHEMBL946281 (1) CHEMBL1047005 (1)
CHEMBL1047006 (1) CHEMBL1047009 (1)
CHEMBL2318589 (1) CHEMBL2318597 (1)
1 / 1
Q8TCC7 Solute carrier family 22 member 8 Antiporter CHEMBL576 CHEMBL2076228 (1)
0 / 0
Q7Z4W1 L-xylulose reductase Enzyme CHEMBL576 CHEMBL706159 (1)
0 / 1
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein CHEMBL576 CHEMBL853264 (1)
1 / 5

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D019802 64849 SLC13A3
NADC3
SDCT2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Succinic Acid binds to SLC13A3 protein affects binding
protein 12397032

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (17)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00025 Penile cancer Q00987 (related)
H00028 Choriocarcinoma Q00987 (related)
H00036 Osteosarcoma Q00987 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00042 Glioma Q00987 (related)
H01065 Pentosuria Q7Z4W1 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003128 D019802 COMA therapeutic
15337580
D062787 D019802 Drug Overdose therapeutic
15337580
D007035 D019802 Hypothermia therapeutic
15337580