PCIDB

KNApSAcK Metabolite C00015542

Metabolite

KNApSAcK Entry

id C00015542
Name 4,7-dihydroxy-2,3,6-trimethoxyphenanthrene
CAS RN 35450-72-7
Standard InChI InChI=1S/C17H16O5/c1-20-13-8-11-9(6-12(13)18)4-5-10-7-14(21-2)17(22-3)16(19)15(10)11/h4-8,18-19H,1-3H3
Standard InChI (Main Layer) InChI=1S/C17H16O5/c1-20-13-8-11-9(6-12(13)18)4-5-10-7-14(21-2)17(22-3)16(19)15(10)11/h4-8,18-19H,1-3H3

Cluster

Phytochemical cluster No. 27
KCF-S cluster No. 104

Link

ChEMBL

By standard InChI CHEMBL1346456
By standard InChI Main Layer CHEMBL1346456

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Combretaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Combretum apiculatum 493957 Combretaceae rosids Viridiplantae

Human Protein / Gene in interaction

34 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL1346456 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1346456 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1346456 CHEMBL2114784 (1)
1 / 1
P14618 Pyruvate kinase PKM Enzyme CHEMBL1346456 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL1346456 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1346456 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1346456 CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1346456 CHEMBL1738493 (1) CHEMBL1738375 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL1346456 CHEMBL2354282 (1)
4 / 2
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL1346456 CHEMBL1738240 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL1346456 CHEMBL1738240 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL1346456 CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1346456 CHEMBL1614166 (1)
1 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1346456 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL1346456 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1346456 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1346456 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1346456 CHEMBL1794401 (1)
0 / 0
P98073 Enteropeptidase Enzyme CHEMBL1346456 CHEMBL1738398 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1346456 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1346456 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1346456 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1346456 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1346456 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1346456 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1346456 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1346456 CHEMBL1613829 (1) CHEMBL1613928 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1346456 CHEMBL1738442 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1346456 CHEMBL2354311 (1)
1 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme CHEMBL1346456 CHEMBL1614105 (1) CHEMBL1614290 (1)
0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein CHEMBL1346456 CHEMBL1614105 (1) CHEMBL1614290 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1346456 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL1346456 CHEMBL2114796 (1)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1346456 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#210900 Bloom syndrome; blm P54132
#114500 Colorectal cancer; crc Q14191
#127750 Dementia, lewy body; dlb P37840
#226200 Enterokinase deficiency P98073
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (13)

KEGG disease name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00988 Enterokinase deficiency P98073 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)