Species

KNApSAcK Entry

Organism name Combretum apiculatum
Genus Combretum
Family Combretaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Combretum apiculatum
Linked NCBI taxonomy ID 493957
Linked level species

Family

Family in NCBI taxonomy Combretaceae
ID 3954

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00015209 External link 512 2,3-Dimethoxy-4,6,7-trihydroxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00033689 External link 512 Callosin
No. 75 No. 28
C00015243 External link 512 2,6-Dihydroxy-3,4,7-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015683 External link 512 7-Hydroxy-2,3,4,6-tetramethoxy-9,10-dihydrophenanthrene
CHEMBL79985
No. 75 No. 28
C00015256 External link 512 2,7-Dihydroxy-3,4,6-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015607 External link 512 6,7-Dihydroxy-2,3,4-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015545 External link 512 4,7-Dihydroxy-2,6-dimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015540 External link 512 4,7-Dihydorxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015425 External link 512 3-Hydroxy-2,4,6,7-tetramethoxy-9,10-dihydrophenanthrene
No. 75 No. 28
C00015313 External link 512 3,4'-Dihydroxy-4,5-dimethoxybibenzyl
No. 96 No. 26
C00015538 External link 512 4,5-Dimethoxy-3,3',4'-trihydroxybibenzyl
No. 96 No. 26
C00015306 External link 512 3,4'-Dihydroxy-3',4,5-trimethoxybibenzyl
No. 96 No. 26
C00015403 External link 512 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene
No. 104 No. 27
C00015542 External link 512 4,7-dihydroxy-2,3,6-trimethoxyphenanthrene
CHEMBL1346456
34 / 20 / 13 No. 104 No. 27
C00015210 External link 512 4,6,7-Trihydroxy-2,3-dimethoxyphenanthrene
/ 2,3-Dimethoxy-4,6,7-trihydroxyphenanthrene
No. 104 No. 27
C00015539 External link 512 4,6-Dimethoxy,2,3,7-trihydroxyphenanthrene
No. 104 No. 27
C00015244 External link 512 2,6-Dihydroxy-3,4,7-trimethoxyphenanthrene
No. 104 No. 27
C00015315 External link 512 3,4'-Dihydroxy-5-methoxybibenzyl
CHEMBL448371
No. 242 No. 26
C00035241 External link 512 9,10-Dihydrophenanthrene
No. 6139

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00015542 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00015542 0 / 0
Q99700 Ataxin-2 Unclassified protein C00015542 1 / 1
P14618 Pyruvate kinase PKM Enzyme C00015542 0 / 0
P06746 DNA polymerase beta Enzyme C00015542 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00015542 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00015542 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00015542 0 / 0
P37840 Alpha-synuclein Unclassified protein C00015542 4 / 2
Q00535 Cyclin-dependent kinase 5 Cdk5 C00015542 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00015542 0 / 0
P54132 Bloom syndrome protein Enzyme C00015542 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00015542 1 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00015542 2 / 2
P39748 Flap endonuclease 1 Enzyme C00015542 0 / 0
O75496 Geminin Unclassified protein C00015542 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00015542 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00015542 0 / 0
P98073 Enteropeptidase Enzyme C00015542 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00015542 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00015542 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00015542 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00015542 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00015542 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00015542 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00015542 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00015542 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00015542 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00015542 1 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00015542 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00015542 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00015542 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00015542 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00015542 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#210900 Bloom syndrome; blm P54132
#114500 Colorectal cancer; crc Q14191
#127750 Dementia, lewy body; dlb P37840
#226200 Enterokinase deficiency P98073
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (13)

KEGG name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00988 Enterokinase deficiency P98073 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)