PCIDB

KNApSAcK Metabolite C00002898

Metabolite

KNApSAcK Entry

id C00002898
Name Pinosylvin methyl ether / 3-Hydroxy-5-methoxystilbene
CAS RN 35302-70-6
Standard InChI InChI=1S/C15H14O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-11,16H,1H3/b8-7+
Standard InChI (Main Layer) InChI=1S/C15H14O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-11,16H,1H3

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 295

Link

ChEMBL

By standard InChI CHEMBL186366
By standard InChI Main Layer CHEMBL186366

KEGG

By LinkDB C10276

CTD

By CAS RN

Species

Summary

Plant class

class name count
Spermatophyta 56
rosids 2
Magnoliophyta 1

Family

family name count
Pinaceae 56
Betulaceae 2
Lauraceae 1

List (59)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alnus crispa 3518 Betulaceae rosids Viridiplantae
Alnus sieboldiana 253221 Betulaceae rosids Viridiplantae
Cryptocarya idenburgensis 22027 Lauraceae Magnoliophyta Viridiplantae
Pinus albicaulis 71622 Pinaceae Spermatophyta Viridiplantae
Pinus aristata 71623 Pinaceae Spermatophyta Viridiplantae
Pinus armandii 88733 Pinaceae Spermatophyta Viridiplantae
Pinus attenuata 71624 Pinaceae Spermatophyta Viridiplantae
Pinus ayacahuite 71625 Pinaceae Spermatophyta Viridiplantae
Pinus balfouriana 3338 Pinaceae Spermatophyta Viridiplantae
Pinus banksiana 3353 Pinaceae Spermatophyta Viridiplantae
Pinus canariensis 49510 Pinaceae Spermatophyta Viridiplantae
Pinus caribaea 70929 Pinaceae Spermatophyta Viridiplantae
Pinus cembra 58041 Pinaceae Spermatophyta Viridiplantae
Pinus cembroides 71627 Pinaceae Spermatophyta Viridiplantae
Pinus clausa 261911 Pinaceae Spermatophyta Viridiplantae
Pinus contorta 3339 Pinaceae Spermatophyta Viridiplantae
Pinus contorta var. latifolia 1281737 Pinaceae Spermatophyta Viridiplantae
Pinus coulteri 3351 Pinaceae Spermatophyta Viridiplantae
Pinus densata 190402 Pinaceae Spermatophyta Viridiplantae
Pinus densiflora 77912 Pinaceae Spermatophyta Viridiplantae
Pinus echinata 71631 Pinaceae Spermatophyta Viridiplantae
Pinus excelsa 3318 Pinaceae Spermatophyta Viridiplantae
Pinus flexilis 151559 Pinaceae Spermatophyta Viridiplantae
Pinus gerardiana 71632 Pinaceae Spermatophyta Viridiplantae
Pinus glabra 368921 Pinaceae Spermatophyta Viridiplantae
Pinus halepensis 71633 Pinaceae Spermatophyta Viridiplantae
Pinus jeffreyi 55061 Pinaceae Spermatophyta Viridiplantae
Pinus khasya 3318 Pinaceae Spermatophyta Viridiplantae
Pinus koraiensis 88728 Pinaceae Spermatophyta Viridiplantae
Pinus krempfii 3342 Pinaceae Spermatophyta Viridiplantae
Pinus leiophylla 71638 Pinaceae Spermatophyta Viridiplantae
Pinus longifolia 3318 Pinaceae Spermatophyta Viridiplantae
Pinus lumholtzii 71639 Pinaceae Spermatophyta Viridiplantae
Pinus massoniana 88730 Pinaceae Spermatophyta Viridiplantae
Pinus montana 28528 Pinaceae Spermatophyta Viridiplantae
Pinus montezumae 71642 Pinaceae Spermatophyta Viridiplantae
Pinus monticola 3345 Pinaceae Spermatophyta Viridiplantae
Pinus morrisonicola 139307 Pinaceae Spermatophyta Viridiplantae
Pinus mugo 28528 Pinaceae Spermatophyta Viridiplantae
Pinus muricata 164245 Pinaceae Spermatophyta Viridiplantae
Pinus nigra 58042 Pinaceae Spermatophyta Viridiplantae
Pinus occidentalis 268872 Pinaceae Spermatophyta Viridiplantae
Pinus palustris 46836 Pinaceae Spermatophyta Viridiplantae
Pinus parviflora 71644 Pinaceae Spermatophyta Viridiplantae
Pinus pentaphylla 399187 Pinaceae Spermatophyta Viridiplantae
Pinus pinaster 71647 Pinaceae Spermatophyta Viridiplantae
Pinus pinea 3346 Pinaceae Spermatophyta Viridiplantae
Pinus ponderosa 55062 Pinaceae Spermatophyta Viridiplantae
Pinus pumila 71649 Pinaceae Spermatophyta Viridiplantae
Pinus pungens 164241 Pinaceae Spermatophyta Viridiplantae
Pinus radiata 3347 Pinaceae Spermatophyta Viridiplantae
Pinus resinosa 54921 Pinaceae Spermatophyta Viridiplantae
Pinus rigida 164242 Pinaceae Spermatophyta Viridiplantae
Pinus sabiniana 268869 Pinaceae Spermatophyta Viridiplantae
Pinus sibirica 62752 Pinaceae Spermatophyta Viridiplantae
Pinus strobus 3348 Pinaceae Spermatophyta Viridiplantae
Pinus sylvestris 3349 Pinaceae Spermatophyta Viridiplantae
Pinus taeda 3352 Pinaceae Spermatophyta Viridiplantae
Pinus virginiana 71654 Pinaceae Spermatophyta Viridiplantae

Human Protein / Gene in interaction

18 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL186366 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL186366 CHEMBL1613842 (1)
4 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL186366 CHEMBL1614331 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL186366 CHEMBL2354282 (1)
4 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL186366 CHEMBL1614458 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL186366 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL186366 CHEMBL2114807 (1)
4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL186366 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL186366 CHEMBL2114810 (1)
7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL186366 CHEMBL1794467 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL186366 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL186366 CHEMBL1614038 (1)
2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL186366 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL186366 CHEMBL1614250 (1) CHEMBL1614502 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL186366 CHEMBL1613914 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL186366 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL186366 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL186366 CHEMBL1614257 (1)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (57)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)