KNApSAcK Entry

Organism name Pinus cembra
Genus Pinus
Family Pinaceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Pinus cembra
Linked NCBI taxonomy ID 58041
Linked level species


Family in NCBI taxonomy Pinaceae
ID 3318

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00000992 External link 512 Pinocembrin
18 / 23 / 23 5 / 0 No. 25 No. 14
C00015762 External link 512 3-Methoxy-5-phenethylphenol
/ Dihydropinosylvin monomethyl ether
2 / 0 / 3 No. 242 No. 26
C00002878 External link 512 Dihydropinosylvin
/ 3,5-Dihydroxybibenzyl
2 / 0 / 3 No. 242 No. 26
C00002897 External link 512 Pinosylvin
/ Pinosylvine
/ 3,5-Dihydroxystilbene
1 / 0 / 1 No. 295 No. 13
C00002898 External link 512 Pinosylvin methyl ether
/ 3-Hydroxy-5-methoxystilbene
18 / 39 / 57 No. 295 No. 13
C00000805 External link 512 alpha-Pinene
3 / 3 / 2 0 / 1 No. 476 No. 35
C00000816 External link 512 beta-Pinene
No. 476 No. 35
C00000823 External link 512 Limonene
7 / 21 / 48 6 / 6 No. 848 No. 35
C00011067 External link 512 Tricyclene
/ Teresantanane
No. 1225
C00031258 External link 512 Sabinene
/ 4(10)-Thujene
No. 1343 No. 35
C00003051 External link 512 alpha-Phellandrene
No. 1898 No. 35
C00000853 External link 512 Myrcene
3 / 3 / 3 No. 2285 No. 34
C00003029 External link 512 Camphene
No. 2460 No. 35
C00003061 External link 512 gamma-Terpinene
/ 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene
No. 2468 No. 35
C00000861 External link 512 Terpinolene
1 / 0 No. 3725
C00029844 External link 512 Bornyl acetate
4 / 1 / 4 No. 4140 No. 35
C00042269 External link 512 Azulene
No. 5021

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000823 C00002878 C00015762 0 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000992 C00002898 0 / 1
O00255 Menin Unclassified protein C00000992 C00002898 2 / 5
P04637 Cellular tumor antigen p53 Transcription Factor C00000823 C00002898 7 / 37
P10636 Microtubule-associated protein tau Unclassified protein C00000992 C00002898 4 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000992 C00002898 1 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000992 C00002898 3 / 3
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000992 C00002898 7 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002878 C00015762 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000805 C00000853 3 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00000992 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000823 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000823 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00000992 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000992 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000992 0 / 1
P08047 Transcription factor Sp1 Unclassified protein C00000992 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002898 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00029844 0 / 0
O75496 Geminin Unclassified protein C00002898 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002898 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002898 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000823 11 / 10
P37840 Alpha-synuclein Unclassified protein C00002898 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002898 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000853 0 / 1
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000992 4 / 4
Q96RI1 Bile acid receptor NR1H4 C00000853 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000805 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000992 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002898 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002898 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000992 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000992 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000992 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000992 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000823 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000823 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002897 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00029844 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002898 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002898 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002898 4 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000992 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00029844 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00029844 1 / 4

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000823
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC: C00000823
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC: C00000823
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000823
4852 NPY, PYY4 neuropeptide Y C00000823
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000823
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC: C00000992
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC: C00000992
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC: C00000992
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC: C00000992
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC: C00000992
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC: C00000861

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (63)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

D003877 Dermatitis, Contact C00000805
D008114 Liver Neoplasms, Experimental C00000823
D008107 Liver Diseases C00000823
D007674 Kidney Diseases C00000823
D008569 Memory Disorders C00000823
D013276 Stomach Ulcer C00000823