Species

KNApSAcK Entry

Organism name Pinus taeda
Genus Pinus
Family Pinaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pinus taeda
Linked NCBI taxonomy ID 3352
Linked level species

Family

Family in NCBI taxonomy Pinaceae
ID 3318

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009076 External link 512 Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009074 External link 512 Procyanidin B7
/ Catechin-(4beta->6)-catechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009089 External link 512 Arecatannin B1
CHEMBL592329
2 / 3 / 4 No. 29 No. 19
C00009097 External link 512 Arecatamnin A1
/ [Epicatechin-(4beta->8)]2-catechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00009098 External link 512 Procyanidin C1
/ [Epicatechin-(4beta->8)]2-epicatechin
CHEMBL290632
13 / 5 / 6 No. 29 No. 19
C00009086 External link 512 Epicatechin-(4beta->6)-epicatechin-(4beta->8)-catechin
CHEMBL592228
2 / 3 / 4 No. 29 No. 19
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003444 External link 512 miropinic acid
/ Isopimaric acid
/ isodextropimaric acid
CHEMBL512164
C115138
3 / 1 / 1 No. 208 No. 48
C00002897 External link 512 Pinosylvin
/ Pinosylvine
/ 3,5-Dihydroxystilbene
CHEMBL101506
CHEMBL2203685
1 / 0 / 1 No. 295 No. 13
C00002898 External link 512 Pinosylvin methyl ether
/ 3-Hydroxy-5-methoxystilbene
CHEMBL186366
18 / 39 / 57 No. 295 No. 13
C00042455 External link 512 Dehydroabietic acid
CHEMBL12850
C013913
No. 323 No. 41
C00015883 External link 512 Stilbene
CHEMBL113028
CHEMBL393702
2 / 2 / 2 No. 3909

Human Protein / Gene in interactions

52 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08253 72 kDa type IV collagenase M10A C00009086 C00009089 C00009097 C00009098 1 / 3
P14780 Matrix metalloproteinase-9 M10A C00009086 C00009089 C00009097 C00009098 2 / 2
P41743 Protein kinase C iota type Iota C00009097 C00009098 0 / 0
P24723 Protein kinase C eta type Eta C00009097 C00009098 1 / 0
P05771 Protein kinase C beta type Alpha C00009097 C00009098 0 / 0
P05129 Protein kinase C gamma type Alpha C00009097 C00009098 1 / 1
Q05655 Protein kinase C delta type Delta C00009097 C00009098 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00015883 C00023770 0 / 0
P17252 Protein kinase C alpha type Alpha C00009097 C00009098 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00009097 C00009098 0 / 0
Q02156 Protein kinase C epsilon type Eta C00009097 C00009098 0 / 0
Q04759 Protein kinase C theta type Delta C00009097 C00009098 0 / 1
Q05513 Protein kinase C zeta type Iota C00009097 C00009098 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002898 C00023770 0 / 1
Q15139 Serine/threonine-protein kinase D1 Pkd C00009097 C00009098 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00023770 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002898 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003444 0 / 0
O75496 Geminin Unclassified protein C00002898 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002898 4 / 2
P49841 Glycogen synthase kinase-3 beta Gsk C00023770 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002898 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002898 7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002898 0 / 0
P00734 Prothrombin S1A C00023770 4 / 2
P14679 Tyrosinase Oxidoreductase C00023770 4 / 2
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00003444 1 / 1
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00003444 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002898 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002898 2 / 2
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00023770 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00023770 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002898 4 / 3
P06239 Tyrosine-protein kinase Lck Src C00002897 0 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00023770 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002898 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002898 1 / 0
O00255 Menin Unclassified protein C00002898 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002898 1 / 2
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P37840 Alpha-synuclein Unclassified protein C00002898 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00023770 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002898 0 / 0
P06746 DNA polymerase beta Enzyme C00023770 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00015883 2 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein C00023770 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002898 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002898 7 / 37
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00023770 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (65)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (73)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
P08253 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)