Species

KNApSAcK Entry

Organism name Pinus contorta
Genus Pinus
Family Pinaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pinus contorta
Linked NCBI taxonomy ID 3339
Linked level species

Family

Family in NCBI taxonomy Pinaceae
ID 3318

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005435 External link 512 Quercetin 3,3'-diglucoside
No. 1 No. 15
C00006005 External link 512 Isorhamnetin 3-(6''-acetylglucoside)
CHEMBL390639
No. 2 No. 15
C00005801 External link 512 6-C-Methylkaempferol 3-glucoside
No. 2 No. 15
C00005961 External link 512 Helichrysoside
CHEMBL437553
C084710
No. 30 No. 15
C00005851 External link 512 Tiliroside
/ Potengriffioside A
/ Kaempferol 3-O-beta-D-(6''-coumaroyl)-glucopyranoside
CHEMBL266564
CHEMBL499705
C052083
2 / 1 / 2 No. 30 No. 15
C00005960 External link 512 Quercetin 3-(3''-p-coumarylglucoside)
No. 30 No. 15
C00004884 External link 512 6-C-Methylkaempferol
No. 67 No. 15
C00023423 External link 512 18-Nor-8(17),13E-labdadiene-4alpha,15-diol
No. 165
C00022718 External link 512 13-Epitorreferol
CHEMBL596905
CHEMBL1521278
3 / 15 / 12 No. 256 No. 46
C00022762 External link 512 epi-13-Manool
CHEMBL561922
No. 256 No. 46
C00002897 External link 512 Pinosylvin
/ Pinosylvine
/ 3,5-Dihydroxystilbene
CHEMBL101506
CHEMBL2203685
1 / 0 / 1 No. 295 No. 13
C00002898 External link 512 Pinosylvin methyl ether
/ 3-Hydroxy-5-methoxystilbene
CHEMBL186366
18 / 39 / 57 No. 295 No. 13
C00000100 External link 512 IAA
/ Indole-3-acetic acid
CHEMBL82411
C030737
3 / 0 / 0 2 / 1 No. 1432 No. 4
C00000869 External link 512 Abietal
/ 7,13-Abietadien-18-al
/ Abieta-7,13-diene-18-al
CHEMBL563793
No. 1536 No. 40
C00000868 External link 512 Abieta-7,13-diene
No. 1536 No. 40
C00000871 External link 512 Abietic acid
/ 7,13-Abietadien-18-oic acid
CHEMBL71893
CHEMBL1336124
CHEMBL1357151
CHEMBL1514489
CHEMBL1552001
C023710
18 / 22 / 25 No. 1536 No. 40
C00000870 External link 512 Abietol
/ Abietinol
/ Abieta-7,13-diene-18-ol
CHEMBL304954
CHEMBL1436063
C026490
9 / 12 / 10 No. 1536 No. 40
C00000101 External link 512 IAA methyl ester
/ Methyl indole-3-acetate
No. 4225

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000871 C00002898 C00005851 C00022718 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000870 C00000871 C00002898 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000870 C00000871 C00002898 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000870 C00000871 C00022718 11 / 10
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000871 C00002898 0 / 0
Q16654 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial Pdhk C00000870 C00000871 0 / 0
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00000870 C00000871 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000871 C00002898 4 / 3
Q15119 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial Pdhk C00000870 C00000871 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000870 C00000871 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000871 C00002898 3 / 3
Q15120 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial Pdhk C00000870 C00000871 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002898 C00022718 4 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000870 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002898 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002898 7 / 3
O75496 Geminin Unclassified protein C00002898 0 / 0
Q9HBH1 Peptide deformylase, mitochondrial Enzyme C00000100 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002898 4 / 2
P11473 Vitamin D3 receptor NR1I1 C00000871 2 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002898 2 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000871 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000871 1 / 1
P02768 Serum albumin Secreted protein C00000100 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005851 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002897 0 / 1
P37840 Alpha-synuclein Unclassified protein C00002898 4 / 2
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000871 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002898 1 / 0
O00255 Menin Unclassified protein C00002898 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002898 1 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002898 0 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00000100 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000871 0 / 3
P04637 Cellular tumor antigen p53 Transcription Factor C00002898 7 / 37
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000871 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000100
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000100

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (55)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#300905 Charcot-marie-tooth disease, x-linked dominant, 6; cmtx6 Q15120
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989

KEGG DISEASE (74)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00000100