PCIDB

KNApSAcK Metabolite C00035062

Metabolite

KNApSAcK Entry

id C00035062
Name Carvone
CAS RN 99-49-0
Standard InChI InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3
Standard InChI (Main Layer) InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3

Cluster

Phytochemical cluster No. 35
KCF-S cluster No. 1740

Link

ChEMBL

By standard InChI CHEMBL15676
By standard InChI Main Layer CHEMBL15676 CHEMBL501949

KEGG

By LinkDB

CTD

By CAS RN C006923

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL501949 CHEMBL1794499 (1)
2 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL501949 CHEMBL1794399 (1)
3 / 1
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL501949 CHEMBL1614458 (2)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL501949 CHEMBL2114842 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL501949 CHEMBL2114890 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL501949 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL501949 CHEMBL1614531 (1)
1 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL501949 CHEMBL2354287 (1)
1 / 1

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C006923 2554 GABRA1
ECA4
EJM
EJM5
gamma-aminobutyric acid (GABA) A receptor, alpha 1 carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] affects binding
/ increases activity
/ increases reaction
protein 15588619
C006923 2561 GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2 carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] affects binding
/ increases activity
/ increases reaction
protein 15588619
C006923 2566 GABRG2
CAE2
ECA2
GEFSP3
gamma-aminobutyric acid (GABA) A receptor, gamma 2 carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] affects binding
/ increases activity
/ increases reaction
protein 15588619
C006923 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A carvone results in increased expression of RHOA protein increases expression
protein 12671036
C006923 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
C006923 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B carvone results in increased expression of RHOB protein increases expression
protein 12671036
C006923 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (9)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003877 C006923 Dermatitis, Contact marker/mechanism
710096
D012640 C006923 Seizures therapeutic
18657594