PCIDB

KNApSAcK Metabolite C00003773

Metabolite

KNApSAcK Entry

id C00003773
Name Fucoxanthin
CAS RN 3351-86-8
Standard InChI InChI=1S/C42H58O6/c1-29(18-14-19-31(3)22-23-37-38(6,7)26-35(47-33(5)43)27-40(37,10)46)16-12-13-17-30(2)20-15-21-32(4)36(45)28-42-39(8,9)24-34(44)25-41(42,11)48-42/h12-22,34-35,44,46H,24-28H2,1-11H3/b13-12+,18-14+,20-15+,29-16+,30-17+,31-19+,32-21+/t23-,34-,35-,40+,41+,42-/m0/s1
Standard InChI (Main Layer) InChI=1S/C42H58O6/c1-29(18-14-19-31(3)22-23-37-38(6,7)26-35(47-33(5)43)27-40(37,10)46)16-12-13-17-30(2)20-15-21-32(4)36(45)28-42-39(8,9)24-34(44)25-41(42,11)48-42/h12-22,34-35,44,46H,24-28H2,1-11H3

Cluster

Phytochemical cluster No. 59
KCF-S cluster No. 114

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1575074

KEGG

By LinkDB C08596

CTD

By CAS RN C025164

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1575074 CHEMBL1738132 (1)
7 / 44
Q99700 Ataxin-2 Unclassified protein CHEMBL1575074 CHEMBL2114784 (1)
1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1575074 CHEMBL1738166 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL1575074 CHEMBL1794311 (1)
2 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1575074 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1575074 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL1575074 CHEMBL1614369 (1)
1 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1575074 CHEMBL1614250 (1) CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1575074 CHEMBL2114908 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1575074 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1575074 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1575074 CHEMBL1738442 (1)
0 / 0

CTD interaction (11)

compound gene gene name gene description interaction interaction type form reference
pmid
C025164 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 20594983
C025164 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 fucoxanthin results in decreased expression of BCL2L1 protein decreases expression
protein 20594983
C025164 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 20594983
C025164 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) fucoxanthin results in increased cleavage of CASP3 protein increases cleavage
protein 20594983
C025164 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein] decreases reaction
/ increases cleavage
protein 20594983
C025164 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) fucoxanthin results in increased cleavage of CASP7 protein increases cleavage
protein 20594983
C025164 2697 GJA1
AVSD3
CMDR
CX43
DFNB38
GJAL
HLHS1
HSS
ODDD
gap junction protein, alpha 1, 43kDa fucoxanthin results in increased expression of GJA1 mRNA increases expression
mRNA 19737546
C025164 2697 GJA1
AVSD3
CMDR
CX43
DFNB38
GJAL
HLHS1
HSS
ODDD
gap junction protein, alpha 1, 43kDa fucoxanthin results in increased expression of GJA1 protein increases expression
protein 19737546
C025164 2705 GJB1
CMTX
CMTX1
CX32
gap junction protein, beta 1, 32kDa fucoxanthin results in increased expression of GJB1 mRNA increases expression
mRNA 19737546
C025164 2705 GJB1
CMTX
CMTX1
CX32
gap junction protein, beta 1, 32kDa fucoxanthin results in increased expression of GJB1 protein increases expression
protein 19737546
C025164 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) fucoxanthin results in increased expression of HMOX1 protein increases expression
protein 23358145

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (46)

KEGG disease name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D056486 C025164 Drug-Induced Liver Injury therapeutic
23358145
D006949 C025164 Hyperlipidemias therapeutic
20519145
D015430 C025164 Weight Gain therapeutic
20519145