PCIDB

KNApSAcK Metabolite C00003804

Metabolite

KNApSAcK Entry

id C00003804
Name Oroxylin A
CAS RN 480-11-5
Standard InChI InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL183513
By standard InChI Main Layer CHEMBL183513

KEGG

By LinkDB

CTD

By CAS RN C080669

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08047 Transcription factor Sp1 Unclassified protein CHEMBL183513 CHEMBL1058704 (1)
0 / 0
P16220 Cyclic AMP-responsive element-binding protein 1 Unclassified protein CHEMBL183513 CHEMBL988111 (1) CHEMBL988112 (1)
CHEMBL988113 (1) CHEMBL988114 (1)
1 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL183513 CHEMBL2342404 (1)
1 / 1
P05412 Transcription factor AP-1 Transcription Factor CHEMBL183513 CHEMBL988107 (1) CHEMBL988108 (1)
CHEMBL988109 (1) CHEMBL988110 (1)
0 / 0

CTD interaction (17)

compound gene gene name gene description interaction interaction type form reference
pmid
C080669 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein decreases expression
protein 19135124
C080669 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein decreases expression
protein 19135124
C080669 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein increases cleavage
protein 19135124
C080669 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein decreases expression
protein 19135124
C080669 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein decreases expression
protein 22245252
C080669 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22245252
C080669 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein decreases phosphorylation
protein 22245252
C080669 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22245252
C080669 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein decreases phosphorylation
protein 22245252
C080669 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA decreases expression
mRNA 22245252
C080669 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein decreases expression
protein 22245252
C080669 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein] decreases reaction
/ increases activity
/ increases expression
protein 22245252
C080669 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA decreases expression
mRNA 22245252
C080669 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein decreases expression
protein 22245252
C080669 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein increases degradation
protein 19135124
C080669 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] affects localization
/ decreases reaction
protein 22245252
C080669 7077 TIMP2
CSC-21K
DDC8
TIMP metallopeptidase inhibitor 2 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein increases expression
protein 22245252

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#612160 Histiocytoma, angiomatoid fibrous P16220
#601626 Leukemia, acute myeloid; aml P36888

KEGG DISEASE (1)

KEGG disease name UniProt
H00003 Acute myeloid leukemia (AML) P36888 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 C080669 Amnesia therapeutic
17196405
D009362 C080669 Neoplasm Metastasis therapeutic
22245252