Pajanelia multijuga
Species
KNApSAcK Entry
| Organism name | Pajanelia multijuga |
|---|---|
| Genus | Pajanelia |
| Family | Bignoniaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Bignoniaceae |
|---|---|
| Linked NCBI taxonomy ID | 24079 |
| Linked level | family |
Family
| Family in NCBI taxonomy | Bignoniaceae |
|---|---|
| ID | 24079 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003804
|
Oroxylin A
|
CHEMBL183513
|
C080669
|
4 / 2 / 1 | 12 / 2 | No. 3 | No. 15 |
|
|
C00003794
|
Chrysin
/ 5,7-Dihydroxyflavone / 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
CHEMBL117
|
C043561
|
100 / 89 / 87 | 69 / 6 | No. 76 | No. 15 |
|
Human Protein / Gene in interactions
102 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003794 C00003804 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00003794 C00003804 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00003794 | 2 / 5 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003794 | 3 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003794 | 7 / 37 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003794 | 4 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00003794 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003794 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003794 | 0 / 3 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003794 | 0 / 0 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00003794 | 1 / 0 |
| P62158 | Calmodulin | Unclassified protein | C00003794 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003794 | 1 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00003794 | 1 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00003794 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00003794 | 1 / 2 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00003794 | 1 / 1 |
| Q00534 | Cyclin-dependent kinase 6 | CMGC serine/threonine protein kinase family | C00003794 | 1 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00003794 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00003794 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003794 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003794 | 0 / 1 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00003794 | 0 / 0 |
| Q15078 | Cyclin-dependent kinase 5 activator 1 | REG serine/threonine protein kinase family | C00003794 | 0 / 0 |
| P16220 | Cyclic AMP-responsive element-binding protein 1 | Unclassified protein | C00003804 | 1 / 0 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | C00003794 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003794 | 2 / 3 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00003794 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003794 | 0 / 0 |
| P16581 | E-selectin | Adhesion | C00003794 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00003794 | 1 / 2 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00003794 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00003794 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003794 | 0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | C00003794 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003794 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00003794 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00003794 | 4 / 2 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00003794 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00003794 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00003794 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00003794 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00003794 | 7 / 3 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00003794 | 2 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003794 | 0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003794 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003794 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003794 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00003794 | 4 / 4 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003794 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003794 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003794 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00003794 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00003794 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00003794 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00003794 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00003794 | 2 / 2 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00003794 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003794 | 1 / 1 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003794 | 0 / 0 |
| P14151 | L-selectin | Adhesion | C00003794 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00003794 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003794 | 1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00003794 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003794 | 0 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003794 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003794 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003794 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003794 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003794 | 0 / 0 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00003804 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00003794 | 0 / 1 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00003794 | 0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00003794 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00003794 | 0 / 0 |
| P56937 | 3-keto-steroid reductase | Enzyme | C00003794 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00003794 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003794 | 1 / 2 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00003794 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00003794 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00003794 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00003794 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00003794 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00003794 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00003794 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00003794 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00003794 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00003794 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00003794 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00003794 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00003794 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00003794 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00003794 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00003794 | 1 / 0 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00003794 | 0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00003794 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00003794 | 0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00003794 | 0 / 0 |
| P49840 | Glycogen synthase kinase-3 alpha | Gsk | C00003794 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003794 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00003794 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00003794 | 1 / 1 |
76 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003794
C00003804
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00003794
C00003804
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003794
C00003804
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003794
C00003804
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003794
C00003804
|
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 |
C00003794
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00003794
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003794
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00003794
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00003794
|
| 834 | CASP1, ICE, IL1BC, P45 | caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) |
C00003794
|
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
C00003794
|
| 8714 | ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
C00003794
|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00003794
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00003794
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003794
|
| 1031 | CDKN2C, INK4C, p18, p18-INK4C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
C00003794
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003794
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003794
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003794
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00003794
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00003794
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003794
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003794
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00003794
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00003794
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00003794
|
| 9415 | FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 | fatty acid desaturase 2 (EC:1.14.19.-) |
C00003794
|
| 2203 | FBP1, FBP | fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) |
C00003794
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00003794
|
| 4616 | GADD45B, GADD45BETA, MYD118 | growth arrest and DNA-damage-inducible, beta |
C00003794
|
| 3122 | HLA-DRA, HLA-DRA1, MLRW | major histocompatibility complex, class II, DR alpha |
C00003794
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003794
|
| 3600 | IL15, IL-15 | interleukin 15 |
C00003794
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00003794
|
| 3554 | IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 | interleukin 1 receptor, type I |
C00003794
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00003794
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00003794
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00003794
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00003794
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003794
|
| 5335 | PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 | phospholipase C, gamma 1 (EC:3.1.4.11) |
C00003794
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00003794
|
| 8000 | PSCA, PRO232 | prostate stem cell antigen |
C00003794
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003794
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003794
|
| 6309 | SC5D, ERG3, S5DES, SC5DL | sterol-C5-desaturase (EC:1.14.21.6) |
C00003794
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00003794
|
| 2810 | SFN, YWHAS | stratifin |
C00003794
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00003794
|
| 6783 | SULT1E1, EST, EST-1, ST1E1, STE | sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) |
C00003794
|
| 29110 | TBK1, NAK, T2K | TANK-binding kinase 1 (EC:2.7.11.1) |
C00003794
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00003794
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003794
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00003794
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003794
|
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 |
C00003794
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00003794
|
| 7161 | TP73, P73 | tumor protein p73 |
C00003794
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00003794
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00003794
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00003794
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00003794
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00003794
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00003794
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00003794
|
| 7402 | UTRN, DMDL, DRP, DRP1 | utrophin |
C00003794
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00003794
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00003794
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003804
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003804
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00003804
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003804
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003804
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00003804
|
| 7077 | TIMP2, CSC-21K, DDC8 | TIMP metallopeptidase inhibitor 2 |
C00003804
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (90)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P47869
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #612160 | Histiocytoma, angiomatoid fibrous |
P16220
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| %612223 | Stature quantitative trait locus 11; stqtl11 |
Q00534
|
| #601367 | Stroke, ischemic |
P16109
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #614916 | Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 |
P62158
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (87)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
8 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000707 | Anaphylaxis |
C00003794
|
| D003110 | Colonic Neoplasms |
C00003794
|
| D007249 | Inflammation |
C00003794
|
| D007680 | Kidney Neoplasms |
C00003794
|
| D008175 | Lung Neoplasms |
C00003794
|
| D011230 | Precancerous Conditions |
C00003794
|
| D000647 | Amnesia |
C00003804
|
| D009362 | Neoplasm Metastasis |
C00003804
|