Rhinacanthus nasutus
Species
KNApSAcK Entry
| Organism name | Rhinacanthus nasutus |
|---|---|
| Genus | Rhinacanthus |
| Family | Acanthaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rhinacanthus nasutus |
|---|---|
| Linked NCBI taxonomy ID | 537489 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Acanthaceae |
|---|---|
| ID | 4185 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (26)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001111
|
Wogonin
/ 5,7-Dihydroxy-8-methoxyflavone |
CHEMBL16171
|
C085514
|
27 / 22 / 40 | 18 / 3 | No. 3 | No. 15 |
|
|
C00003804
|
Oroxylin A
|
CHEMBL183513
|
C080669
|
4 / 2 / 1 | 12 / 2 | No. 3 | No. 15 |
|
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00007558
|
Syringaldehyde
/ 4-Hydroxy-3,5-dimethoxybenzaldehyde |
CHEMBL225303
|
C069665
|
No. 856 |
|
|||
|
C00041106
|
Rhinacanthin P
/ (-)-Rhinacanthin P |
No. 886 |
|
|||||
|
C00041094
|
Rhinacanthin B
|
No. 886 |
|
|||||
|
C00041099
|
Rhinacanthin I
/ (-)-Rhinacanthin I |
No. 886 |
|
|||||
|
C00041102
|
Rhinacanthin L
/ (-)-Rhinacanthin L |
No. 886 |
|
|||||
|
C00041098
|
Rhinacanthin H
/ (-)-Rhinacanthin H |
No. 886 |
|
|||||
|
C00041105
|
Rhinacanthin O
/ (-)-Rhinacanthin O |
No. 886 |
|
|||||
|
C00041097
|
Rhinacanthin G
/ (-)-Rhinacanthin G |
No. 886 |
|
|||||
|
C00041101
|
Rhinacanthin K
/ (-)-Rhinacanthin K |
No. 886 |
|
|||||
|
C00041095
|
Rhinacanthin C
|
CHEMBL462962
|
No. 886 |
|
||||
|
C00041100
|
Rhinacanthin J
/ (-)-Rhinacanthin J |
No. 886 |
|
|||||
|
C00030768
|
Methyl vanillate
|
CHEMBL486214
|
No. 1936 |
|
||||
|
C00002657
|
p-Formylphenol
/ 4-Hydroxybenzaldehyde / p-Hydroxybenzaldehyde |
CHEMBL14193
|
C011483
|
3 / 2 / 2 | No. 2076 |
|
||
|
C00041093
|
Rhinacanthin A
/ (-)-Rhinacanthin A |
CHEMBL219325
|
No. 2274 |
|
||||
|
C00037011
|
Dehydro-alpha-lapachone
|
CHEMBL272253
|
C029244
|
1 / 0 / 0 | No. 2274 |
|
||
|
C00041096
|
Rhinacanthin D
|
CHEMBL462963
|
No. 3089 |
|
||||
|
C00041107
|
Rhinacanthin Q
|
CHEMBL184182
|
No. 3089 |
|
||||
|
C00041103
|
Rhinacanthin M
|
CHEMBL188174
|
No. 3089 |
|
||||
|
C00041104
|
Rhinacanthin N
|
CHEMBL188737
|
No. 3089 |
|
||||
|
C00041108
|
Rhinacanthone
|
CHEMBL512946
|
C420690
|
No. 3485 |
|
|||
|
C00000708
|
Rhinacanthin E
|
CHEMBL463086
|
No. 4230 |
|
||||
|
C00000709
|
Rhinacanthin F
|
CHEMBL464737
|
No. 4230 |
|
||||
|
C00007468
|
Allantoin
|
CHEMBL593429
CHEMBL1230080 |
D000481
|
12 / 12 / 14 | No. 8950 |
|
Human Protein / Gene in interactions
47 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001111 C00003749 C00003804 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00002657 C00037011 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00007468 | 0 / 0 |
| O14924 | Regulator of G-protein signaling 12 | Unclassified protein | C00007468 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00007468 | 1 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00007468 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00007468 | 3 / 2 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002657 | 1 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001111 | 0 / 1 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001111 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00007468 | 0 / 1 |
| P16220 | Cyclic AMP-responsive element-binding protein 1 | Unclassified protein | C00003804 | 1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003749 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003749 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00007468 | 2 / 3 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00003804 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001111 | 7 / 37 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001111 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00001111 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001111 | 4 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001111 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00007468 | 0 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002657 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001111 | 0 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00001111 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00007468 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00007468 | 0 / 1 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00003804 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00007468 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00007468 | 1 / 4 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001111 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001111 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001111 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001111 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001111 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001111 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001111 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001111 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001111 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001111 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001111 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001111 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001111 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001111 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001111 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001111 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001111 | 0 / 0 |
26 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001111
C00003804
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00001111
C00003804
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001111
C00003804
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001111
C00003804
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001111
C00003804
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001111
C00003804
|
| 7077 | TIMP2, CSC-21K, DDC8 | TIMP metallopeptidase inhibitor 2 |
C00003804
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003804
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003804
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003804
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00003804
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00003804
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001111
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001111
|
| 857 | CAV1, BSCL3, CGL3, MSTP085, PPH3, VIP21, CAV | caveolin 1, caveolae protein, 22kDa |
C00001111
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00001111
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001111
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001111
|
| 1806 | DPYD, DHP, DHPDHASE, DPD | dihydropyrimidine dehydrogenase (EC:1.3.1.2) |
C00001111
|
| 9 | NAT1, AAC1, MNAT, NAT-1, NATI | N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) |
C00001111
|
| 5584 | PRKCI, DXS1179E, PKCI, nPKC-iota | protein kinase C, iota (EC:2.7.11.13) |
C00001111
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001111
|
| 7298 | TYMS, HST422, TMS, TS | thymidylate synthetase (EC:2.1.1.45) |
C00001111
|
| 7372 | UMPS, OPRT | uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23) |
C00001111
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (38)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P47869
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #612160 | Histiocytoma, angiomatoid fibrous |
P16220
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00079 | Asthma |
P07550
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D009374 | Neoplasms, Experimental |
C00003749
C00001111 |
| D014947 | Wounds and Injuries |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D009202 | Cardiomyopathies |
C00003749
|
| D000647 | Amnesia |
C00003804
|
| D009362 | Neoplasm Metastasis |
C00003804
|
| D005770 | Gastrointestinal Neoplasms |
C00001111
|
| D009361 | Neoplasm Invasiveness |
C00001111
|