PCIDB

KNApSAcK Metabolite C00004624

Metabolite

KNApSAcK Entry

id C00004624
Name Morin / 3,5,7,2',4'-Pentahydroxyflavonol / 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CAS RN 480-16-0
Standard InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
Standard InChI (Main Layer) InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL28626
By standard InChI Main Layer CHEMBL28626

KEGG

By LinkDB C10105

CTD

By CAS RN C008548

Human Protein / Gene in interaction

59 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL28626 CHEMBL2076023 (1) CHEMBL2076033 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL28626 CHEMBL1613992 (1)
7 / 44
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL28626 CHEMBL1614529 (1)
0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL28626 CHEMBL2169429 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL28626 CHEMBL1738312 (1)
0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL28626 CHEMBL2169431 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL28626 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL28626 CHEMBL1738091 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL28626 CHEMBL1794573 (1)
2 / 2
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL28626 CHEMBL641515 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL28626 CHEMBL1614079 (2)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL28626 CHEMBL1614076 (1)
1 / 1
P29466 Caspase-1 C14 CHEMBL28626 CHEMBL1614158 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL28626 CHEMBL1738600 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL28626 CHEMBL1613927 (1)
0 / 0
Q96S37 Solute carrier family 22 member 12 Transporter CHEMBL28626 CHEMBL925845 (1) CHEMBL925847 (1)
1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL28626 CHEMBL1023248 (1)
1 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL28626 CHEMBL926333 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL28626 CHEMBL2077116 (1) CHEMBL2075617 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL28626 CHEMBL1614027 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL28626 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL28626 CHEMBL2039370 (1) CHEMBL2039371 (1)
CHEMBL2039375 (1) CHEMBL2039376 (1)
CHEMBL2039377 (1) CHEMBL2039379 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL28626 CHEMBL1614166 (1)
1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL28626 CHEMBL1014692 (1) CHEMBL1014697 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL28626 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL28626 CHEMBL1613922 (1) CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL28626 CHEMBL1738606 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL28626 CHEMBL1614377 (1)
0 / 1
Q14790 Caspase-8 C14 CHEMBL28626 CHEMBL2014551 (1)
2 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL28626 CHEMBL1794569 (1)
1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL28626 CHEMBL1614257 (4) CHEMBL1614410 (1)
CHEMBL1614531 (4)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL28626 CHEMBL1738610 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL28626 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL28626 CHEMBL1794467 (1)
0 / 0
P56817 Beta-secretase 1 A1A CHEMBL28626 CHEMBL1771831 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL28626 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL28626 CHEMBL1687393 (1) CHEMBL1687394 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL28626 CHEMBL1006005 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL28626 CHEMBL1614038 (2)
2 / 2
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL28626 CHEMBL985261 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL28626 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL28626 CHEMBL1614240 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL28626 CHEMBL1613779 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL28626 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL28626 CHEMBL1794483 (2)
0 / 0
Q15046 Lysine--tRNA ligase Enzyme CHEMBL28626 CHEMBL2173401 (1) CHEMBL2173408 (1)
2 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL28626 CHEMBL1614283 (1) CHEMBL1614211 (4)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL28626 CHEMBL1614250 (1) CHEMBL1614421 (4)
CHEMBL1614502 (4)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL28626 CHEMBL1738402 (2)
0 / 0
Q04760 Lactoylglutathione lyase Enzyme CHEMBL28626 CHEMBL684310 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL28626 CHEMBL1794536 (4)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL28626 CHEMBL1613914 (4)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL28626 CHEMBL1613829 (4)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL28626 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL28626 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL28626 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL28626 CHEMBL1614257 (4) CHEMBL1614531 (4)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL28626 CHEMBL1613933 (3)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL28626 CHEMBL1613933 (3)
1 / 6

CTD interaction (9)

compound gene gene name gene description interaction interaction type form reference
pmid
C008548 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 morin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C008548 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein morin affects the reaction [APP protein binds to APP protein] affects binding
/ affects reaction
protein 18537544
C008548 3458 IFNG
IFG
IFI
interferon, gamma morin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide] affects cotreatment
/ decreases reaction
/ increases abundance
protein 22698256
C008548 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 morin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] decreases reaction
/ increases uptake
protein 17976262
C008548 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of morin increases glucuronidation
protein 14557274
C008548 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of morin increases glucuronidation
protein 14557274
C008548 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of morin increases glucuronidation
protein 14557274
C008548 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of morin increases glucuronidation
protein 14557274
C008548 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of morin increases glucuronidation
protein 14557274

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#607271 Caspase 8 deficiency Q14790
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#119900 Digital clubbing, isolated congenital P15428
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#220150 Hypouricemia, renal, 1; rhuc1 Q96S37
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
Q14790
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (67)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
Q92731 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00108 Autoimmune lymphoproliferative syndromes (ALPS) Q14790 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q15046 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00948 Renal hypouricemia (RHUC) Q96S37 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006528 C008548 Carcinoma, Hepatocellular therapeutic
17950263
19539802
D056486 C008548 Drug-Induced Liver Injury therapeutic
17696131
D007511 C008548 Ischemia therapeutic
16806951
D007674 C008548 Kidney Diseases therapeutic
18787798
D008106 C008548 Liver Cirrhosis, Experimental therapeutic
18629640
D008114 C008548 Liver Neoplasms, Experimental therapeutic
19539802
D009374 C008548 Neoplasms, Experimental therapeutic
17950263
D015431 C008548 Weight Loss therapeutic
17950263