Artocarpus integrifolia
Species
KNApSAcK Entry
| Organism name | Artocarpus integrifolia |
|---|---|
| Genus | Artocarpus |
| Family | Moraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Artocarpus integer |
|---|---|
| Linked NCBI taxonomy ID | 3490 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Moraceae |
|---|---|
| ID | 3487 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004624
|
Morin
/ 3,5,7,2',4'-Pentahydroxyflavonol / 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one |
CHEMBL28626
|
C008548
|
59 / 40 / 67 | 9 / 8 | No. 3 | No. 15 |
|
|
C00004062
|
Isoartocarpin
/ Cycloartocarpin |
No. 14 | No. 15 |
|
||||
|
C00008362
|
Artocarpanone
|
CHEMBL467194
|
No. 25 | No. 14 |
|
|||
|
C00008990
|
Cyanomaclurin
|
No. 52 | No. 14 |
|
||||
|
C00013502
|
Oxyisocyclointegrin
/ 6,7-Dihydro-3,9-dihydroxy-6-(1-hydroxy-1-methylethyl)-11-methoxy-8H-[1]benzopyrano[3,2-d][1]benzoxepin-8-one |
No. 139 |
|
|||||
|
C00013503
|
Cyclointegrin
/ 7,8-Dihydro-3,10-dihydroxy-12-methoxy-6,6-dimethyl-6H,9H-[1]benzopyrano[3,2-e][1]benzoxocin-9-one |
No. 139 |
|
Human Protein / Gene in interactions
59 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00004624 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00004624 | 7 / 37 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00004624 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00004624 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00004624 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00004624 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00004624 | 2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00004624 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00004624 | 2 / 2 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00004624 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00004624 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00004624 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00004624 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00004624 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00004624 | 0 / 0 |
| Q96S37 | Solute carrier family 22 member 12 | Transporter | C00004624 | 1 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00004624 | 1 / 1 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00004624 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00004624 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00004624 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00004624 | 1 / 2 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00004624 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00004624 | 1 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00004624 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00004624 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00004624 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00004624 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00004624 | 0 / 1 |
| Q14790 | Caspase-8 | C14 | C00004624 | 2 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00004624 | 1 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00004624 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00004624 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00004624 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00004624 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00004624 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00004624 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00004624 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00004624 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00004624 | 2 / 2 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00004624 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00004624 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00004624 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00004624 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00004624 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00004624 | 0 / 0 |
| Q15046 | Lysine--tRNA ligase | Enzyme | C00004624 | 2 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00004624 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00004624 | 4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00004624 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00004624 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00004624 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00004624 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00004624 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00004624 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00004624 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00004624 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00004624 | 2 / 5 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00004624 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00004624 | 1 / 4 |
9 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00004624
|
| 351 | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 | amyloid beta (A4) precursor protein |
C00004624
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00004624
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00004624
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00004624
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00004624
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00004624
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00004624
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00004624
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (40)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #607271 | Caspase 8 deficiency |
Q14790
|
| #613641 | Charcot-marie-tooth disease, recessive intermediate b; cmtrib |
Q15046
|
| #613916 | Deafness, autosomal recessive 89; dfnb89 |
Q15046
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #220150 | Hypouricemia, renal, 1; rhuc1 |
Q96S37
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P04637
Q14790 |
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (67)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
Q92731 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00108 | Autoimmune lymphoproliferative syndromes (ALPS) |
Q14790
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
Q15046
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00948 | Renal hypouricemia (RHUC) |
Q96S37
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
8 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006528 | Carcinoma, Hepatocellular |
C00004624
|
| D056486 | Drug-Induced Liver Injury |
C00004624
|
| D007511 | Ischemia |
C00004624
|
| D007674 | Kidney Diseases |
C00004624
|
| D008106 | Liver Cirrhosis, Experimental |
C00004624
|
| D008114 | Liver Neoplasms, Experimental |
C00004624
|
| D009374 | Neoplasms, Experimental |
C00004624
|
| D015431 | Weight Loss |
C00004624
|