KNApSAcK Metabolite C00000750
Metabolite
KNApSAcK Entry
| id | C00000750 |
|---|---|
| Name | Phenylacetic acid |
| CAS RN | 103-82-2 |
| Standard InChI | InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10) |
| Standard InChI (Main Layer) | InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2481 |
Link
ChEMBL
| By standard InChI | CHEMBL1044 |
|---|---|
| By standard InChI Main Layer | CHEMBL1044 |
KEGG
| By LinkDB | C07086 |
|---|
CTD
| By CAS RN | C025136 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 2 |
Family
| family name | count |
|---|---|
| Fabaceae | 2 |
| Enterobacteriaceae | 1 |
| Streptomycetaceae | 1 |
| Pseudomonadaceae | 1 |
| Xylariaceae | 1 |
List (6)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Anthyllis subsimplex | 118889 | Fabaceae | rosids | Viridiplantae |
| Biscogniauxia mediterranea | 97377 | Xylariaceae | Fungi | |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria | |
| Pisum sativum | 3888 | Fabaceae | rosids | Viridiplantae |
| Pseudomonas pseudoalcaligenes | 330 | Pseudomonadaceae | Bacteria | |
| Streptomyces humidus S5-55 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P15121 | Aldose reductase | Enzyme | CHEMBL1044 |
CHEMBL924228
(1)
|
0 / 0 |
| P27169 | Serum paraoxonase/arylesterase 1 | Enzyme | CHEMBL1044 |
CHEMBL991845
(1)
|
1 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL1044 |
CHEMBL706267
(1)
|
0 / 1 |
CTD interaction (14)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
affects cotreatment
/ decreases reaction / increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
affects cotreatment
/ decreases reaction / increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | PON1 promoter SNP results in decreased hydrolysis of phenylacetic acid |
decreases hydrolysis
|
promoter |
16117861
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | PON1 protein affects the metabolism of phenylacetic acid |
affects metabolic processing
|
protein |
11304470
15924216 16079929 |
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | PON1 protein polymorphism affects the metabolism of phenylacetic acid |
affects metabolic processing
|
protein |
15924216
|
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | PON1 protein results in increased hydrolysis of phenylacetic acid |
increases hydrolysis
|
protein |
9746266
15375178 16052486 16117861 20176005 |
| C025136 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| C025136 | 5445 |
PON2
|
paraoxonase 2 (EC:3.1.1.2 3.1.1.81) | PON2 protein results in increased hydrolysis of phenylacetic acid |
increases hydrolysis
|
protein |
16117861
|
| C025136 | 5445 |
PON2
|
paraoxonase 2 (EC:3.1.1.2 3.1.1.81) | PON2 protein SNP results in decreased hydrolysis of phenylacetic acid |
decreases hydrolysis
|
protein |
16117861
|
| C025136 | 5446 |
PON3
|
paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | PON3 protein results in increased hydrolysis of phenylacetic acid |
increases hydrolysis
|
protein |
16099434
16139510 |