PCIDB

KNApSAcK Metabolite C00008866

Metabolite

KNApSAcK Entry

id C00008866
Name (-)-Epicatechin gallate / (-)-Epicatechin 3-O-gallate
CAS RN 1257-08-5
Standard InChI InChI=1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21-/m1/s1
Standard InChI (Main Layer) InChI=1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 219

Link

ChEMBL

By standard InChI CHEMBL36327
By standard InChI Main Layer CHEMBL36327 CHEMBL78573 CHEMBL328085 CHEMBL126142 CHEMBL129451 CHEMBL483083 CHEMBL1514905

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

41 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL36327 CHEMBL2077004 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL36327 CHEMBL1664298 (1)
0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme CHEMBL36327 CHEMBL129451 CHEMBL921930 (2)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1514905 CHEMBL1614331 (1)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL36327 CHEMBL1177441 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1514905 CHEMBL1794311 (1)
2 / 3
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL36327 CHEMBL129451 CHEMBL926465 (2) CHEMBL926470 (2)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1514905 CHEMBL1613800 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL36327 CHEMBL954481 (1) CHEMBL954483 (1)
CHEMBL954488 (1) CHEMBL954489 (1)
CHEMBL954492 (1) CHEMBL954496 (1)
CHEMBL954498 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL36327 CHEMBL129451 CHEMBL926467 (2) CHEMBL926472 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1514905 CHEMBL1794467 (1)
0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL36327 CHEMBL1056838 (1) CHEMBL1056839 (1)
2 / 3
P56817 Beta-secretase 1 A1A CHEMBL126142 CHEMBL129451 CHEMBL653507 (2) CHEMBL653508 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1514905 CHEMBL1613910 (1)
3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL36327 CHEMBL2076880 (1) CHEMBL2077620 (1)
1 / 1
P27540 Aryl hydrocarbon receptor nuclear translocator Unclassified protein CHEMBL36327 CHEMBL954482 (1) CHEMBL954490 (1)
CHEMBL954494 (1) CHEMBL954497 (1)
0 / 0
P00374 Dihydrofolate reductase Oxidoreductase CHEMBL36327 CHEMBL930269 (1)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL328085 CHEMBL1119333 (1)
1 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL36327 CHEMBL129451 CHEMBL926466 (2) CHEMBL926471 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1514905 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1514905 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1514905 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1514905 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein CHEMBL36327 CHEMBL937576 (1)
0 / 7
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1514905 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1514905 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1514905 CHEMBL1613829 (1) CHEMBL1613928 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1514905 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL1514905 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1514905 CHEMBL1614257 (1)
1 / 3
Q05513 Protein kinase C zeta type Iota CHEMBL78573 CHEMBL769344 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL78573 CHEMBL769344 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL78573 CHEMBL769344 (1) CHEMBL768504 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#237500 Dubin-johnson syndrome; djs Q92887
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#112100 Yt blood group antigen P22303

KEGG DISEASE (30)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00036 Osteosarcoma P08684 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)