Rheum sp.
Species
KNApSAcK Entry
| Organism name | Rheum sp. |
|---|---|
| Genus | Rheum |
| Family | Polygonaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rheum |
|---|---|
| Linked NCBI taxonomy ID | 3620 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Polygonaceae |
|---|---|
| ID | 3615 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (30)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00008855
|
Catechin 3'-O-beta-D-glucopyranoside
|
No. 12 | No. 14 |
|
||||
|
C00008856
|
Catechin 4'-O-beta-D-glucopyranoside
|
No. 12 | No. 14 |
|
||||
|
C00008852
|
Catechin 7-O-beta-D-glucopyranoside
|
No. 12 | No. 14 |
|
||||
|
C00008846
|
Catechin-5-O-beta-D-glucopyranoside
/ (+)-Catechin-5-O-beta-D-glucopyranoside |
No. 12 | No. 14 |
|
||||
|
C00009074
|
Procyanidin B7
/ Catechin-(4beta->6)-catechin |
CHEMBL506487
CHEMBL502984 CHEMBL451115 |
No. 16 | No. 19 |
|
|||
|
C00009207
|
3-O-Galloylepicatechin-(4beta->6)-epicatechin-3-O-gallate
|
No. 29 | No. 19 |
|
||||
|
C00009206
|
3-O-Galloylepicatechin-(4beta->6)-catechin
|
No. 29 | No. 19 |
|
||||
|
C00009210
|
Catechin-(4alpha->8)-epicatechin-3-O-gallate
|
No. 29 | No. 19 |
|
||||
|
C00009211
|
3-O-Galloylepicatechin-(4beta->8)-catechin
|
No. 29 | No. 19 |
|
||||
|
C00009212
|
Epicatechin-(4beta->8)-epicatechin-3-O-gallate
|
No. 29 | No. 19 |
|
||||
|
C00009213
|
3-O-Galloylepicatechin-(4beta->8)-epicatechin-3-O-gallate
|
CHEMBL39504
|
11 / 2 / 2 | No. 29 | No. 19 |
|
||
|
C00009220
|
[3-O-Galloylepicatechin-(4beta->6)]2-epicatechin-3-O-gallate
|
No. 113 | No. 19 |
|
||||
|
C00009228
|
Epicatechin-(4beta->8)-3-O-galloylepicatechin-(4beta->8)-epicatechin-3-O-gallate
|
No. 113 | No. 19 |
|
||||
|
C00009222
|
3-O-Galloylepicatechin-(4beta->6)-3-O-galloylepicatechin-(4beta->8)-epicatechin-3-O-gallate
|
No. 113 | No. 19 |
|
||||
|
C00009226
|
[3-Galloylepicatechin-(4beta->8)]2-catechin
|
No. 113 | No. 19 |
|
||||
|
C00009223
|
3-O-Galloylepicatechin-(4beta->8)-3-O-galloylepicatechin-(4beta->6)-catechin
|
No. 113 | No. 19 |
|
||||
|
C00009221
|
3-O-Galloylepicatechin-(4beta->6)-3-O-galloylepicatechin-(4beta->8)-catechin
|
No. 113 | No. 19 |
|
||||
|
C00009229
|
[3-O-Galloylepicatechin-(4beta->8)]2-epicatechin-3-O-gallate
|
CHEMBL262261
CHEMBL386276 |
11 / 2 / 2 | No. 113 | No. 19 |
|
||
|
C00008859
|
Catechin 7,3'-di-O-beta-D-glucopyranoside
|
No. 152 |
|
|||||
|
C00008858
|
Catechin 5,4'-di-O-beta-D-glucopyranoside
|
No. 152 |
|
|||||
|
C00008857
|
Catechin 5,3'-di-O-beta-D-glucopyranoside
|
No. 152 |
|
|||||
|
C00008860
|
Catechin 3',4'-di-O-beta-D-glucopyranoside
|
No. 152 |
|
|||||
|
C00008866
|
(-)-Epicatechin gallate
/ (-)-Epicatechin 3-O-gallate |
CHEMBL36327
CHEMBL78573 CHEMBL328085 CHEMBL126142 CHEMBL129451 CHEMBL483083 CHEMBL1514905 |
41 / 20 / 30 | No. 219 | No. 14 |
|
||
|
C00006359
|
8-C-Glucopyranosylcatechin
|
No. 261 | No. 14 |
|
||||
|
C00006358
|
6-C-Glucopyranosylcatechin
|
No. 261 | No. 14 |
|
||||
|
C00009201
|
7-O-beta-D-Glucopyranosylcatechin-(4alpha->8)-catechin
|
No. 341 |
|
|||||
|
C00006329
|
8-C-Glucopyranosylprocyanidin B1
|
No. 341 |
|
|||||
|
C00006328
|
6-C-Glucopyranosylprocyanidin B1
|
No. 341 |
|
|||||
|
C00006327
|
8-C-Glucopyranosylprocyanidin B2
|
No. 341 |
|
|||||
|
C00006326
|
6-C-Glucopyranosylprocyanidin B2
|
No. 341 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00008866 C00009213 C00009229 | 0 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00008866 C00009213 C00009229 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00008866 C00009213 C00009229 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00008866 C00009213 C00009229 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00008866 C00009213 C00009229 | 1 / 1 |
| Q05655 | Protein kinase C delta type | Delta | C00008866 C00009213 C00009229 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00008866 C00009213 C00009229 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00008866 C00009213 C00009229 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00008866 C00009213 C00009229 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00008866 C00009213 C00009229 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00008866 C00009213 C00009229 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00008866 | 0 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00008866 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00008866 | 3 / 3 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00008866 | 1 / 1 |
| P27540 | Aryl hydrocarbon receptor nuclear translocator | Unclassified protein | C00008866 | 0 / 0 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00008866 | 1 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | C00008866 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00008866 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00008866 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00008866 | 2 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00008866 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00008866 | 4 / 3 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00008866 | 0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00008866 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00008866 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00008866 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00008866 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00008866 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00008866 | 1 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00008866 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00008866 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00008866 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00008866 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00008866 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00008866 | 2 / 3 |
| P02768 | Serum albumin | Secreted protein | C00008866 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00008866 | 0 / 0 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00008866 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00008866 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00008866 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (30)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
| H00018 | Gastric cancer |
P08581
(related)
P10415 (related) |
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00046 | Cholangiocarcinoma |
P08581
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
|
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00028 | Choriocarcinoma |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|