KCF-S cluster No. 2865 (4 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (4)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count

---

Cumulative family count

class name	count
Sphingomonadaceae	3
Tricholomataceae	1

KEGG BRITE br08003

---

Categories (0)

br08003 Category	# of metabolite

---

metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (4)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00007485	Tetrachlorohydroquinone / 2,3,5,6-Tetrachlorohydroquinone	CHEMBL2074639	C044578	1 / 1 / 0	3 / 0
C00007486	2,3,6-Trichloro-p-hydroquinone
C00007496	Pentachlorophenol	CHEMBL75967	D010416	34 / 52 / 73	38 / 23
C00016089	Tetrachloro-pyrocatechol		C423629		2 / 0

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00007496	7 / 37
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00007496	2 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00007496	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00007496	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00007496	3 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00007496	3 / 1
P08183	Multidrug resistance protein 1	drug	C00007485	1 / 0
P11473	Vitamin D3 receptor	NR1I1	C00007496	2 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00007496	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00007496	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00007496	2 / 0
O75496	Geminin	Unclassified protein	C00007496	0 / 0
P10145	Interleukin-8	Secreted protein	C00007496	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00007496	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00007496	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00007496	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00007496	0 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00007496	5 / 3
Q96RI1	Bile acid receptor	NR1H4	C00007496	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00007496	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00007496	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00007496	0 / 0
P03372	Estrogen receptor	NR3A1	C00007496	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00007496	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00007496	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00007496	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00007496	0 / 0
P10275	Androgen receptor	NR3C4	C00007496	3 / 4
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00007496	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00007496	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00007496	1 / 0
O00255	Menin	Unclassified protein	C00007496	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00007496	1 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00007496	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00007496	1 / 1

41 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1434	CSE1L, CAS, CSE1, XPO2	CSE1 chromosome segregation 1-like (yeast)	C00007485 C00007496
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00007496 C00016089
2071	ERCC3, BTF2, GTF2H, RAD25, TFIIH, XPB	excision repair cross-complementing rodent repair deficiency, complementation group 3 (EC:3.6.4.12)	C00007496
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00007485
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00016089
126	ADH1C, ADH3	alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1)	C00007496
127	ADH4, ADH-2	alcohol dehydrogenase 4 (class II), pi polypeptide (EC:1.1.1.1)	C00007496
128	ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR	alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284)	C00007496
131	ADH7, ADH4	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (EC:1.1.1.1)	C00007496
6348	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3	chemokine (C-C motif) ligand 3	C00007496
1234	CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22	chemokine (C-C motif) receptor 5 (gene/pseudogene)	C00007496
1583	CYP11A1, CYP11A, CYPXIA1, P450SCC	cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6)	C00007496
1586	CYP17A1, CPT7, CYP17, P450C17, S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	C00007496
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00007496
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00007496
1555	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	C00007496
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00007496
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00007496
1551	CYP3A7, CP37, CYPIIIA7, P450-HFLA	cytochrome P450, family 3, subfamily A, polypeptide 7 (EC:1.14.14.1)	C00007496
11080	DNAJB4, DNAJW, DjB4, HLJ1	DnaJ (Hsp40) homolog, subfamily B, member 4	C00007496
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00007485
2072	ERCC4, ERCC11, FANCQ, RAD1, XPF	excision repair cross-complementing rodent repair deficiency, complementation group 4	C00007496
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00007496
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00007496
3295	HSD17B4, DBP, MFE-2, MPF-2, PRLTS1, SDR8C1	hydroxysteroid (17-beta) dehydrogenase 4 (EC:4.2.1.107 4.2.1.119 1.1.1.n12)	C00007496
3283	HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (EC:1.1.1.145 5.3.3.1)	C00007496
3320	HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	C00007496
59067	IL21, IL-21, Za11	interleukin 21	C00007496
4055	LTBR, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3	lymphotoxin beta receptor (TNFR superfamily, member 3)	C00007496
9	NAT1, AAC1, MNAT, NAT-1, NATI	N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5)	C00007496
5241	PGR, NR3C3, PR	progesterone receptor	C00007496
5447	POR, CPR, CYPOR, P450R	P450 (cytochrome) oxidoreductase (EC:1.6.2.4)	C00007496
5886	RAD23A, HHR23A, HR23A	RAD23 homolog A (S. cerevisiae)	C00007496
6462	SHBG, ABP, SBP, TEBG	sex hormone-binding globulin	C00007496
6770	STAR, STARD1	steroidogenic acute regulatory protein	C00007496
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00007496
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00007496
8717	TRADD, Hs.89862	TNFRSF1A-associated via death domain	C00007496
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00007496
6846	XCL2, SCM-1b, SCM1B, SCYC2	chemokine (C motif) ligand 2	C00007496
7518	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	C00007496

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions