Bryonia dioica

• Index
• Plant Species
• Natural Activity
• Metabolite list (22)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Bryonia dioica
Genus	Bryonia
Family	Cucurbitaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Bryonia dioica
Linked NCBI taxonomy ID	3652
Linked level	species

Family

Family in NCBI taxonomy	Cucurbitaceae
ID	3650

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (6)

Species	Activity
Bryonia dioica Jacq.	Antitumor
Bryonia dioica Jacq.	Cytotoxic
Bryonia dioica Jacq.	Diuretic
Bryonia dioica Jacq.	Emetic
Bryonia dioica Jacq.	Laxative
Bryonia dioica Jacq.	toxic

Metabolite list (22)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00006224	Saponarin		C457771			No. 1	No. 15
C00014076	Isovitexin 7-O-(6'''-caffeoyl)-beta-D-glucopyranoside					No. 7	No. 15
C00029859	Bryonolic acid	CHEMBL482596 CHEMBL1982562	C074984			No. 13	No. 51
C00038091	(24R)-24-Hydroxy-24-vinyllathosterol					No. 111	No. 11
C00038092	(24S)-24-Hydroxy-24-vinyllathosterol					No. 111	No. 11
C00003678	Bryodulcosigenin	CHEMBL465204				No. 119	No. 51
C00045246	Bryonioside E / (+)-Bryonioside E	CHEMBL503377				No. 202
C00045245	Bryonioside D / (+)-Bryonioside D	CHEMBL507538				No. 202
C00045247	Bryonioside F / (+)-Bryonioside F	CHEMBL451089				No. 202
C00045242	Bryonioside A / (+)-Bryonioside A	CHEMBL450045				No. 202
C00045249	Cabenoside D	CHEMBL510167 CHEMBL1996311				No. 202
C00031748	Dihydrocucurbitacin B	CHEMBL553851		1 / 1 / 2		No. 220	No. 11
C00003683	Cucurbitacin B	CHEMBL367917 CHEMBL508185 CHEMBL507237 CHEMBL1708265 CHEMBL1728549	C041246	22 / 30 / 28		No. 220	No. 11
C00003690	Cucurbitacin J	CHEMBL1923789 CHEMBL1923790 CHEMBL1984707				No. 220	No. 11
C00003689	Cucurbitacin I	CHEMBL387737 CHEMBL1317135 CHEMBL1717364	C038106	20 / 15 / 15	2 / 0	No. 220	No. 11
C00003685	Cucurbitacin D	CHEMBL493646 CHEMBL492404	C038105	1 / 0 / 0		No. 220	No. 11
C00003686	Cucurbitacin E	CHEMBL455056	C102326	3 / 1 / 2		No. 220	No. 11
C00032785	Bryoamaride / Cucurbitacin l 2-O-beta-D-glucopyranoside	CHEMBL449483		1 / 4 / 2		No. 315
C00045243	Bryonioside B / (+)-Bryonioside B	CHEMBL464459 CHEMBL1991496				No. 675	No. 51
C00045244	Bryonioside C / (+)-Bryonioside C	CHEMBL454236				No. 675	No. 51
C00045248	Bryonioside G / (+)-Bryonioside G	CHEMBL472126				No. 675	No. 51
C00003694	Cucurbitacin S		D054728			No. 7002	No. 11

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P20701	Integrin alpha-L	Membrane receptor	C00003683 C00003685 C00003686 C00003689	0 / 0
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00003683 C00003686 C00031748	1 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003683 C00003689	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003683 C00003689	1 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003683 C00003689	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003683 C00003689	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003683 C00003689	2 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003683 C00003689	2 / 3
Q16637	Survival motor neuron protein	Unclassified protein	C00003683 C00003689	4 / 1
P23528	Cofilin-1	Unclassified protein	C00003686 C00003689	0 / 0
O75496	Geminin	Unclassified protein	C00003683 C00003689	0 / 0
Q06710	Paired box protein Pax-8	Unclassified protein	C00003683 C00003689	1 / 2
P42858	Huntingtin	Unclassified protein	C00003683	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00003683	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003683	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003689	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00003683	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003689	0 / 1
P11308	Transcriptional regulator ERG	Unclassified protein	C00003689	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00003683	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00003683	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00032785	4 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003689	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003683	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003683	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003689	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003689	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00003683	4 / 3
P02545	Prelamin-A/C	Unclassified protein	C00003683	11 / 10
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003689	1 / 1
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00003683	1 / 4
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003689	0 / 3
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003689	1 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3717	JAK2, JTK10, THCYT3	Janus kinase 2 (EC:2.7.10.2)	C00003689
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00003689

Related Diseases

Diseases related to proteins in ChEMBL interactions