Azadirachta indica
Species
KNApSAcK Entry
| Organism name | Azadirachta indica |
|---|---|
| Genus | Azadirachta |
| Family | Meliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Azadirachta indica |
|---|---|
| Linked NCBI taxonomy ID | 124943 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Meliaceae |
|---|---|
| ID | 43707 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (49)
| Species | Activity |
|---|---|
| Azadirachta indica A. Juss. | Alterative |
| Azadirachta indica A. Juss. | Amebicide |
| Azadirachta indica A. Juss. | Analgesic |
| Azadirachta indica A. Juss. | Anorectic |
| Azadirachta indica A. Juss. | Antiaggregant |
| Azadirachta indica A. Juss. | Antiarrhythmic |
| Azadirachta indica A. Juss. | Antibacterial |
| Azadirachta indica A. Juss. | Antidiabetic |
| Azadirachta indica A. Juss. | Antifeedant |
| Azadirachta indica A. Juss. | Antiinflammatory |
| Azadirachta indica A. Juss. | Antiperiodic |
| Azadirachta indica A. Juss. | Antiplaque |
| Azadirachta indica A. Juss. | Antipyretic |
| Azadirachta indica A. Juss. | Antiseptic |
| Azadirachta indica A. Juss. | Antiviral |
| Azadirachta indica A. Juss. | Aphrodisiac |
| Azadirachta indica A. Juss. | Astringent |
| Azadirachta indica A. Juss. | Bitter |
| Azadirachta indica A. Juss. | Carminative |
| Azadirachta indica A. Juss. | Contraceptive |
| Azadirachta indica A. Juss. | Demulcent |
| Azadirachta indica A. Juss. | Deobstruent |
| Azadirachta indica A. Juss. | Depurative |
| Azadirachta indica A. Juss. | Detersive |
| Azadirachta indica A. Juss. | Discutient |
| Azadirachta indica A. Juss. | Diuretic |
| Azadirachta indica A. Juss. | Emmenagogue |
| Azadirachta indica A. Juss. | Emollient |
| Azadirachta indica A. Juss. | Errhine |
| Azadirachta indica A. Juss. | Expectorant |
| Azadirachta indica A. Juss. | Fungicide |
| Azadirachta indica A. Juss. | Insectifuge |
| Azadirachta indica A. Juss. | Larvicide |
| Azadirachta indica A. Juss. | Laxative |
| Azadirachta indica A. Juss. | Narcotic |
| Azadirachta indica A. Juss. | Nematicide |
| Azadirachta indica A. Juss. | Parasiticide |
| Azadirachta indica A. Juss. | Pectoral |
| Azadirachta indica A. Juss. | Pediculicide |
| Azadirachta indica A. Juss. | Pesticide |
| Azadirachta indica A. Juss. | Pulicide |
| Azadirachta indica A. Juss. | Sedative |
| Azadirachta indica A. Juss. | Spermicide |
| Azadirachta indica A. Juss. | Stimulant |
| Azadirachta indica A. Juss. | Stomachic |
| Azadirachta indica A. Juss. | Tonc |
| Azadirachta indica A. Juss. | Uterocontractant |
| Azadirachta indica A. Juss. | Vermifuge |
| Azadirachta indica A. Juss. | Vulnerary |
Metabolite list (26)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00008267
|
Nimbaflavone
/ 5,7-Dihydroxy-4'-methoxy-8,3'-di-C-prenylflavanone |
CHEMBL560530
|
No. 19 | No. 14 |
|
|||
|
C00008508
|
5,7-Dihydroxy-4'-methoxy-8-C-prenyl-3'-(3-hydroxy-3-methylbutyl)flavanone
|
No. 19 | No. 14 |
|
||||
|
C00014163
|
Flowerone
/ 5,7,8,4'-Tetrahydroxy-3'-prenylflavanone |
No. 28 | No. 14 |
|
||||
|
C00014162
|
Flowerine
/ 5-Hydroxy-7,4'-dimethoxy-8-prenylflavanone |
No. 28 | No. 14 |
|
||||
|
C00038162
|
14,15-Epoxynimonol
|
No. 204 | No. 51 |
|
||||
|
C00036610
|
6alpha-O-Acetyl-7-deacetylnimocinol
/ (+)-6alpha-O-Acetyl-7-deacetylnimocinol |
No. 453 |
|
|||||
|
C00036127
|
Isomeldenin
|
No. 453 |
|
|||||
|
C00036185
|
Nimocinol
/ (+)-Nimocinol |
No. 453 |
|
|||||
|
C00036245
|
Zafaral
|
No. 453 |
|
|||||
|
C00049645
|
Isoazadironolide
/ (+)-Isoazadironolide |
No. 453 |
|
|||||
|
C00049626
|
Azadiradionolide
/ (+)-Azadiradionolide |
CHEMBL1774394
|
No. 453 |
|
||||
|
C00049627
|
Azadironolide
/ (+)-Azadironolide |
No. 453 |
|
|||||
|
C00045169
|
22,23-Dihydronimocinol
/ (-)-22,23-Dihydronimocinol |
CHEMBL491379
|
No. 453 |
|
||||
|
C00049117
|
Azadirolic acid
|
No. 453 |
|
|||||
|
C00049294
|
Salimuzzalin
|
No. 453 |
|
|||||
|
C00045292
|
Desfurano-6alpha-hydroxyazadiradione
/ (-)-Desfurano-6alpha-hydroxyazadiradione |
CHEMBL491380
|
No. 453 |
|
||||
|
C00042264
|
Azadirachtin M
/ (-)-Azadirachtin M |
No. 487 | No. 51 |
|
||||
|
C00042042
|
11-epi-Azadirachtin D
/ (-)-11-epi-Azadirachtin D |
No. 487 | No. 51 |
|
||||
|
C00049545
|
Azadirachtin N
|
No. 487 | No. 51 |
|
||||
|
C00003698
|
Azadirachtin A
|
CHEMBL509309
CHEMBL506084 CHEMBL1557791 |
C010329
|
3 / 0 / 1 | 20 / 3 | No. 487 | No. 51 |
|
|
C00003728
|
Salannin
|
CHEMBL1774412
|
C105836
|
No. 591 | No. 51 |
|
||
|
C00041075
|
n-Tridecyl benzene
|
No. 2819 |
|
|||||
|
C00037491
|
Meliacinol
/ (+)-Meliacinol |
No. 3001 |
|
|||||
|
C00039801
|
Multiplolide A
/ (+)-Multiplolide A |
CHEMBL466333
|
No. 4534 |
|
||||
|
C00049118
|
Azadironol
|
No. 7029 |
|
|||||
|
C00041073
|
Nimbothalin
|
No. 7349 |
|
Human Protein / Gene in interactions
3 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q96RI1 | Bile acid receptor | NR1H4 | C00003698 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003698 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003698 | 0 / 0 |
20 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 317 | APAF1, APAF-1, CED4 | apoptotic peptidase activating factor 1 |
C00003698
|
| 572 | BAD, BBC2, BCL2L8 | BCL2-associated agonist of cell death |
C00003698
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003698
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003698
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003698
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00003698
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003698
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003698
|
| 839 | CASP6, MCH2 | caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) |
C00003698
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003698
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003698
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00003698
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003698
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003698
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00003698
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003698
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003698
|
| 5111 | PCNA | proliferating cell nuclear antigen |
C00003698
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003698
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003698
|