Species

KNApSAcK Entry

Organism name Ternstroemia gymnanthera
Genus Ternstroemia
Family Theaceae / Pentaphylacaceae / Ternstroemiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ternstroemia gymnanthera
Linked NCBI taxonomy ID 107827
Linked level species

Family

Family in NCBI taxonomy Pentaphylacaceae
ID 125045

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00045045 External link 512 Robustanic acid
/ 3beta-Hydroxy-11alpha-methoxyurs-12-en-28-oic acid
No. 13 No. 51
C00031690 External link 512 Corosolic acid
CHEMBL391533
CHEMBL237535
CHEMBL391534
CHEMBL574993
C113861
17 / 7 / 6 No. 13 No. 51
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00019065 External link 512 Erythrodiol
/ 3beta-Erythrodiol
CHEMBL298604
CHEMBL60687
CHEMBL400074
C077953
4 / 0 / 1 No. 13 No. 51
C00030742 External link 512 Maslinic acid
/ Crategolic acid
/ 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid
CHEMBL201515
CHEMBL383749
CHEMBL482673
CHEMBL577380
C412811
8 / 5 / 4 No. 13 No. 51
C00019491 External link 512 Euscophic acid
/ Jacarandic acid
/ 2alpha,3alpha,19alpha-Trihydroxyurs-12-en-28-oic acid
CHEMBL223484
CHEMBL239077
CHEMBL1270647
C007695
2 / 2 / 2 No. 13 No. 51
C00037295 External link 512 Ilelatifol D
No. 23 No. 51
C00037978 External link 512 Ursolic acid lactone
CHEMBL1590724
2 / 4 / 4 No. 23 No. 51
C00003741 External link 512 Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
C002070
34 / 17 / 14 10 / 2 No. 23 No. 51
C00003738 External link 512 beta-Amyrin
/ beta-Amirin
/ beta-Amyrine
/ beta-Amyrenol
C036380
0 / 4 No. 23 No. 51
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11

Human Protein / Gene in interactions

74 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003741 C00019064 C00023770 C00023774 C00031690 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019064 C00019065 C00023770 C00030742 C00031690 0 / 0
P15121 Aldose reductase Enzyme C00003741 C00019064 C00019065 C00030742 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 C00019065 C00030742 C00031690 0 / 1
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003741 C00019064 C00019065 C00030742 0 / 0
O75496 Geminin Unclassified protein C00003741 C00019064 C00031690 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00019491 C00023770 C00031690 1 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00003741 C00019064 C00023770 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 C00030742 C00031690 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 C00030742 C00031690 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003741 C00023770 C00037978 0 / 1
P11217 Glycogen phosphorylase, muscle form Enzyme C00030742 C00031690 1 / 1
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003741 C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003741 C00019064 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003741 C00023770 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00019064 C00031690 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003741 C00023770 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 C00031690 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003741 C00019064 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 C00030742 4 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003741 C00023770 0 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003741 C00023770 2 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 C00031690 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003741 C00023774 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003741 C00023770 1 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00019491 C00031690 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00019064 C00031690 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00019064 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00003741 0 / 0
P42858 Huntingtin Unclassified protein C00031690 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00031690 2 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003741 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003741 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003741 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003741 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003741 1 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00003741 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003741 0 / 0
P00734 Prothrombin S1A C00023770 4 / 2
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
P14679 Tyrosinase Oxidoreductase C00023770 4 / 2
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00003741 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
Q02156 Protein kinase C epsilon type Eta C00003741 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00003741 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003741 0 / 0
P05771 Protein kinase C beta type Alpha C00003741 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P08047 Transcription factor Sp1 Unclassified protein C00023770 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00019064 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00019064 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00037978 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00031690 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003741 11 / 10
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019064 0 / 3
Q99700 Ataxin-2 Unclassified protein C00031690 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00003741 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003741 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003741 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00019064 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019064 1 / 4
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00003741 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00003741 0 / 0

27 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003741 C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003741 C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003741 C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00003741 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00003741 C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00003741
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003741
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00003741
581 BAX, BCL2L4 BCL2-associated X protein C00003741
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003741
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232600 Glycogen storage disease v P11217
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#156250 Metachondromatosis; metcds Q06124
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#163950 Noonan syndrome 1; ns1 Q06124
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (41)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00069 Glycogen storage diseases (GSD) P11217 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

19 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008103 Liver Cirrhosis C00003741
C00019064
D007249 Inflammation C00003738
C00019064
D018149 Glucose Intolerance C00019064
D006930 Hyperalgesia C00003738
D008545 Melanoma C00003741
D010146 Pain C00003738
D002252 Carbon Tetrachloride Poisoning C00019064
D056486 Drug-Induced Liver Injury C00019064
D050171 Dyslipidemias C00019064
D005157 Facial Pain C00003738
D006949 Hyperlipidemias C00019064
D007674 Kidney Diseases C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D009369 Neoplasms C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064