Hemerocallus minor
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00009819
|
Hemerocallone
/ 5,2',5'-Trimethoxy-6,7-methylenedioxyisoflavone |
No. 27 | No. 15 |
|
||||
|
C00000568
|
Chrysophanol
|
CHEMBL41092
|
C027113
|
20 / 17 / 20 | 1 / 0 | No. 41 | No. 62 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00002861
|
Rhein
|
CHEMBL418068
|
C020491
|
60 / 65 / 46 | 8 / 1 | No. 1811 | No. 62 |
|
Human Protein / Gene in interactions
75 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000568 C00002861 C00003672 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000568 C00002861 C00003672 | 3 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000568 C00002861 C00003672 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000568 C00002861 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000568 C00002861 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000568 C00002861 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002861 C00003672 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000568 C00002861 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000568 C00002861 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002861 C00003672 | 2 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000568 C00002861 | 4 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000568 C00002861 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000568 C00002861 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000568 C00002861 | 1 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00002861 C00003672 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000568 C00002861 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000568 C00002861 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000568 C00002861 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000568 C00002861 | 2 / 3 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002861 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00002861 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002861 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00002861 | 1 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002861 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002861 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002861 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00002861 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000568 | 4 / 2 |
| P10145 | Interleukin-8 | Secreted protein | C00002861 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002861 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002861 | 1 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002861 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002861 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000568 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00002861 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002861 | 5 / 3 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002861 | 2 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002861 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00002861 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000568 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002861 | 3 / 3 |
| Q15149 | Plectin | Unclassified protein | C00002861 | 4 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002861 | 2 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002861 | 3 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002861 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002861 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002861 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002861 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002861 | 11 / 10 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000568 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002861 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002861 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002861 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002861 | 2 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002861 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002861 | 1 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002861 | 4 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002861 | 0 / 1 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00002861 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00002861 | 0 / 0 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00002861 | 5 / 1 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00002861 | 2 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002861 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002861 | 2 / 1 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000568
C00002861
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002861
|
| 2064 | ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) |
C00002861
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002861
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002861
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002861
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002861
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002861
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (81)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 Q14191 |
| #162800 | Cyclic neutropenia |
P08246
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #226670 | Epidermolysis bullosa simplex with muscular dystrophy |
Q15149
|
| #612138 | Epidermolysis bullosa simplex with pyloric atresia |
Q15149
|
| #131950 | Epidermolysis bullosa simplex, ogna type |
Q15149
|
| #133239 | Esophageal cancer |
P18054
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613723 | Muscular dystrophy, limb-girdle, type 2q; lgmd2q |
Q15149
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (55)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
Q15149 (related) |
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
Q15149 (related) |
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00042 | Glioma |
P09619
(related)
P16234 (related) |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00585 | Epidermolysis bullosa, hemidesmosomal |
Q15149
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|