Heracleum wallichii

• Index
• Plant Species
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Heracleum wallichii
Genus	Heracleum
Family	Apiaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Heracleum wallichii
Linked NCBI taxonomy ID	491186
Linked level	species

Family

Family in NCBI taxonomy	Apiaceae
ID	4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00025604	Cycleanine / (-)-Cycleanine	CHEMBL1711244 CHEMBL1983719	C037098	7 / 1 / 1		No. 10	No. 4
C00001870	Isobebeerin / Isobebeerine / Isochondodendrine	CHEMBL509310 CHEMBL1169628				No. 10	No. 4
C00023774	Fucostanol / Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol	CHEMBL66943 CHEMBL186373 CHEMBL400247 CHEMBL1568947	D013265	5 / 0 / 0	1 / 0	No. 53	No. 11
C00000583	Isopimpinellin	CHEMBL140796	C015304	9 / 3 / 4	2 / 0	No. 606	No. 25
C00000575	Bergaptan	CHEMBL24171	C022909	22 / 22 / 17	0 / 3	No. 1282	No. 25
C00037321	Isobergapten	CHEMBL141690		8 / 5 / 4		No. 1282	No. 25
C00029297	Columbianetin / (+)-Columbianetin	CHEMBL201152		7 / 12 / 8		No. 1336	No. 25

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000575 C00000583 C00029297 C00037321	0 / 0
P56817	Beta-secretase 1	A1A	C00000575 C00000583 C00029297	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000575 C00029297 C00037321	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000575 C00000583 C00037321	0 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000583 C00029297	2 / 2
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000575 C00000583	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000575 C00029297	7 / 3
O75496	Geminin	Unclassified protein	C00025604 C00037321	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000583 C00023774	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000575	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000575	3 / 2
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00023774	0 / 0
P08183	Multidrug resistance protein 1	drug	C00000575	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000575	0 / 1
P16389	Potassium voltage-gated channel subfamily A member 2	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
P20813	Cytochrome P450 2B6	Cytochrome P450 2B6	C00000575	1 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00029297	2 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000575	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000583	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00025604	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00025604	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00029297	1 / 1
P17658	Potassium voltage-gated channel subfamily A member 6	K	C00000575	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00037321	0 / 0
P22001	Potassium voltage-gated channel subfamily A member 3	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000575	3 / 3
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000575	1 / 0
P09884	DNA polymerase alpha catalytic subunit	Transferase	C00023774	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000575	1 / 1
Q99700	Ataxin-2	Unclassified protein	C00025604	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00025604	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00025604	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000583	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00037321	4 / 3
P48547	Potassium voltage-gated channel subfamily C member 1	K	C00000575	0 / 0
P10275	Androgen receptor	NR3C4	C00000575	3 / 4
P22460	Potassium voltage-gated channel subfamily A member 5	KCNA, Kv1.x (Shaker)	C00000575	1 / 1
Q09470	Potassium voltage-gated channel subfamily A member 1	KCNA, Kv1.x (Shaker)	C00000575	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00037321	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00037321	1 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00025604	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00023774	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00023774	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000583	1 / 1

3 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000583
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000583
10599	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6	solute carrier organic anion transporter family, member 1B1	C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions