PCIDB

Ferulago capillaris

Species

KNApSAcK Entry

Organism name Ferulago capillaris
Genus Ferulago
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ferulago
Linked NCBI taxonomy ID 49865
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002488 External link 512 Osthol
/ Osthole
CHEMBL52229
C046627
12 / 6 / 5 7 / 4 No. 466 No. 25
C00037677 External link 512 Pranferol
/ (-)-Pranferol
C042677
No. 579 No. 25
C00030532 External link 512 Isoimperatorin
CHEMBL448060
C055542
8 / 13 / 11 3 / 1 No. 606 No. 25
C00000575 External link 512 Bergaptan
CHEMBL24171
C022909
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00036282 External link 512 (-)-Isovalerylmarmesin
No. 1319 No. 25
C00036287 External link 512 (-)-Prantschimgin
No. 1319 No. 25
C00013140 External link 512 Alatol
/ Alatol(Euonymus)
No. 4206

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002488 C00030532 0 / 0
P56817 Beta-secretase 1 A1A C00000575 C00002488 C00030532 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 C00002488 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00002488 0 / 0
O75496 Geminin Unclassified protein C00002488 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P04062 Glucosylceramidase Enzyme C00002488 6 / 4
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002488 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 1 / 0
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P02545 Prelamin-A/C Unclassified protein C00030532 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000575 3 / 2
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002488 0 / 0
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002488 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002488 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 7 / 3
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00030532 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002488 0 / 0
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 3 / 3
P22303 Acetylcholinesterase Hydrolase C00030532 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 1 / 1
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00030532 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 0 / 0
P10275 Androgen receptor NR3C4 C00000575 3 / 4
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
O14980 Exportin-1 Unclassified protein C00002488 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00030532 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00030532 1 / 1

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2180 ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) C00002488
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00002488
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002488
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002488
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002488
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002488
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002488
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00030532
2939 GSTA2, GST2, GSTA2-2, GTA2, GTH2 glutathione S-transferase alpha 2 (EC:2.5.1.18) C00030532
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00030532

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (41)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#160120 Episodic ataxia, type 1; ea1 Q09470
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#112100 Yt blood group antigen P22303

KEGG DISEASE (32)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00731 Atrial fibrillation P22460 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00749 Episodic ataxias Q09470 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006505 Hepatitis C00000575
D010787 Photosensitivity Disorders C00000575
D011565 Psoriasis C00000575
C538231 Adenocarcinoma of lung C00002488
D003920 Diabetes Mellitus C00002488
D006943 Hyperglycemia C00002488
D009361 Neoplasm Invasiveness C00002488
D056486 Drug-Induced Liver Injury C00030532