Flourensia cernua
Species
KNApSAcK Entry
| Organism name | Flourensia cernua |
|---|---|
| Genus | Flourensia |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Flourensia |
|---|---|
| Linked NCBI taxonomy ID | 191157 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006381
|
Isoshaftoside
/ Isoschaftoside / Apigenin 6-C-alpha-L-arabinopyranoside-8-C-beta-D-glucopyranoside |
No. 1 | No. 15 |
|
||||
|
C00006382
|
Neoschaftoside
|
CHEMBL1537012
|
7 / 2 / 2 | No. 1 | No. 15 |
|
||
|
C00004640
|
Quercetin 3,4'-dimethyl ether
/ 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone / 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-methoxy-4H-1-benzopyran-4-one |
CHEMBL309263
|
16 / 8 / 2 | No. 3 | No. 15 |
|
||
|
C00004603
|
Penduletin
/ 5,4'-Dihydroxy-3,6,7-trimethoxyflavone / 5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL165509
|
3 / 3 / 0 | No. 3 | No. 15 |
|
||
|
C00004638
|
Quercetin 3,7-dimethyl ether
/ 5,3',4'-Trihydroxy-3,7-dimethoxyflavone / 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL164861
|
C065497
|
2 / 1 / 2 | No. 3 | No. 15 |
|
|
|
C00004596
|
6-Methoxykaempferol 3-methyl ether
/ 5,7,4'-Trihydroxy-3,6-dimethoxyflavone / 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL351607
|
C014868
|
No. 3 | No. 15 |
|
||
|
C00004646
|
Pachypodol
/ Quercetin 3,3',7-trimethyl ether / 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone / 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL165180
|
C008751
|
1 / 2 / 0 | No. 3 | No. 15 |
|
|
|
C00004571
|
Kaempferol 7,4'-dimethyl ether
/ 3,5-Dihydroxy-7,4'-dimethoxyflavone / 3,5-Dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00004692
|
Chrysosplenol D
/ Quercetagetin 3,6,7-Trimethyl ether / 5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone / 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL491366
|
1 / 0 / 0 | No. 3 | No. 15 |
|
||
|
C00004693
|
Jaceidin
/ Quercetagetin 3,3',6-trimethyl ether / 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone |
CHEMBL161878
|
No. 3 | No. 15 |
|
|||
|
C00004648
|
Quercetin 3,3',4'-trimethyl ether
/ 5,7-Dihydroxy-3,3',4'-trimethoxyflavone / 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-3-methoxy-4H-1-benzopyran-4-one |
CHEMBL350720
|
No. 3 | No. 15 |
|
|||
|
C00004533
|
Galangin
/ Norizalpinin / 3,5,7-Trihydroxyflavone / 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one |
CHEMBL309490
|
C037032
|
35 / 34 / 29 | 15 / 4 | No. 76 | No. 15 |
|
|
C00021208
|
Flourensadiol
|
No. 197 | No. 38 |
|
||||
|
C00034475
|
Dehydroflourensic acid
/ (-)-Dehydroflourensic acid |
No. 1429 |
|
|||||
|
C00017294
|
Flourensic acid
/ 9-Oxo-7xi-eremophil-11(13)-en-12-oic acid |
No. 1933 |
|
Human Protein / Gene in interactions
61 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08183 | Multidrug resistance protein 1 | drug | C00004533 C00004603 | 1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00004533 C00006382 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00004603 C00004646 | 2 / 0 |
| P15121 | Aldose reductase | Enzyme | C00004603 C00004692 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00004640 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00004533 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00006382 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00006382 | 1 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00004533 | 1 / 1 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00004533 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00004533 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00004533 | 0 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00004533 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00004533 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00004533 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00006382 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00004533 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00004533 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00004533 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00004533 | 4 / 2 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00004533 | 0 / 0 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00004638 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00006382 | 1 / 1 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00004533 | 0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00004533 | 2 / 2 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00004533 | 4 / 4 |
| P06276 | Cholinesterase | Hydrolase | C00004533 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00004533 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00004533 | 1 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00004533 | 0 / 0 |
| O14763 | Tumor necrosis factor receptor superfamily member 10B | Unclassified protein | C00004640 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00004533 | 1 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00004533 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00004533 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00004533 | 0 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00004533 | 3 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00006382 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00004533 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00004533 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00004533 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00004533 | 3 / 4 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00004533 | 0 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00006382 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00004533 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00004533 | 1 / 2 |
| P00747 | Plasminogen | S1A | C00004638 | 1 / 2 |
| P68366 | Tubulin alpha-4A chain | Structural | C00004640 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00004640 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00004640 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00004640 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00004640 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00004640 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00004640 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00004640 | 2 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00004533 | 0 / 0 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00004640 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00004640 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00004640 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00004640 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00004640 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00004640 | 1 / 0 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00004533
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00004533
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00004533
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00004533
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00004533
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00004533
|
| 2034 | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 | endothelial PAS domain protein 1 |
C00004533
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00004533
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00004533
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00004533
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00004533
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00004533
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00004533
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00004533
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00004533
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (47)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #217090 | Plasminogen deficiency, type i |
P00747
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
O14763
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (35)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00223 | Inherited thrombophilia |
P00747
(related)
|
| H01206 | Plasminogen deficiency |
P00747
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|