PCIDB

Sideritis tenoi

Species

KNApSAcK Entry

Organism name Sideritis tenoi
Genus Sideritis
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sideritis
Linked NCBI taxonomy ID 155231
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00031160 External link 512 Rhoiptelenol
C480303
No. 13 No. 51
C00003738 External link 512 beta-Amyrin
/ beta-Amirin
/ beta-Amyrine
/ beta-Amyrenol
C036380
0 / 4 No. 23 No. 51
C00003737 External link 512 alpha-Amyrin
/ alpha-Amyrine
/ alpha-Amyrenol
No. 23 No. 51
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003647 External link 512 Campesterol
/ 24alpha-Methylcholesterol
/ (24R)24-Methylcholest-5-en-3beta-ol
CHEMBL520535
CHEMBL485421
CHEMBL1836653
C021273
No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 C00003672 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 C00003672 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 C00003672 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 C00003672 0 / 1
P06746 DNA polymerase beta Enzyme C00003672 C00023774 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (41)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#218030 Apparent mineralocorticoid excess; ame P80365
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (24)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005157 Facial Pain C00003738
D006930 Hyperalgesia C00003738
D007249 Inflammation C00003738
D010146 Pain C00003738
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601