PCIDB

Drimys winteri

Species

KNApSAcK Entry

Organism name Drimys winteri
Genus Drimys
Family Winteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Drimys winteri
Linked NCBI taxonomy ID 3419
Linked level species

Family

Family in NCBI taxonomy Winteraceae
ID 3417

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Natural Activity

List (13)

Species Activity
Drimys winteri J.R. & G. Forst. Analgesic
Drimys winteri J.R. & G. Forst. Antibacterial
Drimys winteri J.R. & G. Forst. Antiinflammatory
Drimys winteri J.R. & G. Forst. Antileukemic
Drimys winteri J.R. & G. Forst. Antiscorbutic
Drimys winteri J.R. & G. Forst. Antiseptic
Drimys winteri J.R. & G. Forst. Astringent
Drimys winteri J.R. & G. Forst. Bitter
Drimys winteri J.R. & G. Forst. Carminative
Drimys winteri J.R. & G. Forst. Diaphoretic
Drimys winteri J.R. & G. Forst. Stimulant
Drimys winteri J.R. & G. Forst. Stomachic
Drimys winteri J.R. & G. Forst. Tonic

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003867 External link 512 Velutin
/ Flavoyadorigenin B
/ Luteolin 7,3'-dimethyl ether
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL508292
No. 3 No. 15
C00020306 External link 512 Futronolid
CHEMBL511167
No. 546 No. 38
C00020329 External link 512 Winterin
No. 546 No. 38
C00003236 External link 512 Confertifolin
CHEMBL1993066
No. 546 No. 38
C00020304 External link 512 Isodrimenin
No. 546 No. 38
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00003252 External link 512 Drimenin
CHEMBL457165
No. 950 No. 38
C00020282 External link 512 Drimenol
/ delta7(8)-15-Hydroxyiresane
No. 1202 No. 38
C00003175 External link 512 Polygodial
/ (-)-Polygodial
CHEMBL218100
CHEMBL254550
C034380
2 / 1 / 0 0 / 2 No. 2644 No. 38
C00003165 External link 512 Mukaadial
CHEMBL455627
No. 3151 No. 38
C00037070 External link 512 Drimanial
No. 5550

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00003175 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase C00003175 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (15)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006930 Hyperalgesia C00003175
D010146 Pain C00003175
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601