Magnolia praecocissima
Species
KNApSAcK Entry
| Organism name | Magnolia praecocissima |
|---|---|
| Genus | Magnolia |
| Family | Magnoliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Magnolia praecocissima |
|---|---|
| Linked NCBI taxonomy ID | 81865 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Magnoliaceae |
|---|---|
| ID | 3401 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00033151
|
Magnostellin B
/ (+)-Magnostellin B |
No. 38 | No. 21 |
|
||||
|
C00000640
|
(+)-Eudesmin
|
CHEMBL519099
CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879 |
C105875
|
2 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00032559
|
(-)-Fargesol
|
No. 38 | No. 21 |
|
||||
|
C00000643
|
Kobusin
/ (+)-Kobusin / (+)-Spinescin / Methylpiperitol |
CHEMBL462822
|
No. 38 | No. 21 |
|
|||
|
C00003345
|
Parthenolide
|
CHEMBL363656
CHEMBL477923 CHEMBL388727 CHEMBL465158 CHEMBL540445 CHEMBL1356390 CHEMBL1527933 CHEMBL1601875 CHEMBL1881731 CHEMBL2142363 CHEMBL2357484 |
123 / 80 / 85 | No. 227 | No. 38 |
|
||
|
C00000601
|
(+)-Sesamin
|
CHEMBL43469
CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861 |
C054125
|
20 / 24 / 15 | 0 / 5 | No. 621 | No. 21 |
|
|
C00001259
|
Naphthalene
|
CHEMBL16293
|
C031721
|
6 / 5 / 4 | 43 / 18 | No. 5021 |
|
Human Protein / Gene in interactions
134 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00000601 C00001259 C00003345 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000601 C00003345 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000601 C00003345 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000601 C00003345 | 4 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000601 C00003345 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000601 C00003345 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000601 C00003345 | 0 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000640 C00003345 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001259 C00003345 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000601 C00003345 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000601 C00003345 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000601 C00003345 | 1 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000601 C00003345 | 2 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001259 C00003345 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000601 C00003345 | 2 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000601 C00003345 | 1 / 1 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00003345 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003345 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003345 | 3 / 2 |
| P42574 | Caspase-3 | C14 | C00001259 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00003345 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00003345 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00003345 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00003345 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00003345 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00003345 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00003345 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00003345 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00003345 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00003345 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00003345 | 1 / 8 |
| P17252 | Protein kinase C alpha type | Alpha | C00003345 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00003345 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003345 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00003345 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00003345 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00003345 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00003345 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00003345 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00003345 | 1 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000601 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00003345 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00003345 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003345 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00003345 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003345 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000640 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00003345 | 1 / 1 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00003345 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00003345 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003345 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00003345 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00003345 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00003345 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00003345 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00003345 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00003345 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00003345 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00003345 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00003345 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00003345 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00003345 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00003345 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00003345 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000601 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00003345 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00003345 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000601 | 7 / 3 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003345 | 0 / 0 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00003345 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00003345 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00003345 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000601 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003345 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00003345 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00003345 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00003345 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00003345 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00003345 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00003345 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00003345 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00003345 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00003345 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00003345 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001259 | 2 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00003345 | 1 / 0 |
| P08246 | Neutrophil elastase | S1A | C00003345 | 2 / 1 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00003345 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00003345 | 2 / 2 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000601 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003345 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00003345 | 5 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003345 | 0 / 3 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00003345 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003345 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00003345 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00003345 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00003345 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00003345 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00003345 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00003345 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00003345 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00003345 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00003345 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003345 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003345 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003345 | 1 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00003345 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000601 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000601 | 4 / 1 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00003345 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003345 | 7 / 37 |
| P10275 | Androgen receptor | NR3C4 | C00001259 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00003345 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00003345 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00003345 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00003345 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00003345 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00003345 | 0 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00003345 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00003345 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003345 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003345 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00003345 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003345 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003345 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003345 | 1 / 4 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00003345 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00003345 | 1 / 0 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00001259
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001259
|
| 429 | ASCL1, ASH1, HASH1, MASH1, bHLHa46 | achaete-scute family bHLH transcription factor 1 |
C00001259
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001259
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001259
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001259
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001259
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00001259
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001259
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00001259
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001259
|
| 13107 |
C00001259
|
||
| 29785 | CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 (EC:1.14.14.1) |
C00001259
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001259
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001259
|
| 2052 | EPHX1, EPHX, EPOX, HYL1, MEH | epoxide hydrolase 1, microsomal (xenobiotic) (EC:3.3.2.9) |
C00001259
|
| 2053 | EPHX2, CEH, SEH | epoxide hydrolase 2, cytoplasmic (EC:3.3.2.10 3.1.3.76) |
C00001259
|
| 2252 | FGF7, HBGF-7, KGF | fibroblast growth factor 7 |
C00001259
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00001259
|
| 2521 | FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS | fused in sarcoma |
C00001259
|
| 2642 | GCGR, GGR | glucagon receptor |
C00001259
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00001259
|
| 8870 | IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 | immediate early response 3 |
C00001259
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00001259
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001259
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00001259
|
| 3956 | LGALS1, GAL1, GBP | lectin, galactoside-binding, soluble, 1 |
C00001259
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00001259
|
| 4159 | MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL | melanocortin 3 receptor |
C00001259
|
| 4160 | MC4R | melanocortin 4 receptor |
C00001259
|
| 4161 | MC5R, MC2 | melanocortin 5 receptor |
C00001259
|
| 10403 | NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 | NDC80 kinetochore complex component |
C00001259
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00001259
|
| 5053 | PAH, PH, PKU, PKU1 | phenylalanine hydroxylase (EC:1.14.16.1) |
C00001259
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00001259
|
| 389 | RHOC, ARH9, ARHC, H9, RHOH9 | ras homolog family member C |
C00001259
|
| 7356 | SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1 | secretoglobin, family 1A, member 1 (uteroglobin) |
C00001259
|
| 6855 | SYP, MRXSYP | synaptophysin |
C00001259
|
| 6932 | TCF7, TCF-1 | transcription factor 7 (T-cell specific, HMG-box) |
C00001259
|
| 7076 | TIMP1, CLGI, EPA, EPO, HCI, TIMP | TIMP metallopeptidase inhibitor 1 |
C00001259
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001259
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (96)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (95)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
23 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000014 | Abnormalities, Drug-Induced |
C00001259
|
| D058186 | Acute Kidney Injury |
C00001259
|
| D055371 | Acute Lung Injury |
C00001259
|
| D000743 | Anemia, Hemolytic |
C00001259
|
| D002386 | Cataract |
C00001259
|
| D006456 | Hemoglobinuria |
C00001259
|
| D006529 | Hepatomegaly |
C00001259
|
| D006959 | Hyperoxaluria |
C00001259
|
| D006965 | Hyperplasia |
C00001259
|
| D008114 | Liver Neoplasms, Experimental |
C00001259
|
| D055370 | Lung Injury |
C00001259
|
| D008175 | Lung Neoplasms |
C00001259
|
| D048629 | Micronuclei, Chromosome-Defective |
C00001259
|
| D009336 | Necrosis |
C00001259
|
| D009362 | Neoplasm Metastasis |
C00001259
|
| D011041 | Poisoning |
C00001259
|
| D014133 | Tracheal Diseases |
C00001259
|
| D015431 | Weight Loss |
C00001259
|
| D001930 | Brain Injuries |
C00000601
|
| D002375 | Catalepsy |
C00000601
|
| D018476 | Hypokinesia |
C00000601
|
| D020244 | Infarction, Middle Cerebral Artery |
C00000601
|
| D020734 | Parkinsonian Disorders |
C00000601
|