Species

KNApSAcK Entry

Organism name Populus angustifolia
Genus Populus
Family Salicaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Populus angustifolia
Linked NCBI taxonomy ID 351344
Linked level species

Family

Family in NCBI taxonomy Salicaceae
ID 3688

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007937 External link 512 2',4',6'-Trihydroxy-4-methoxydihydrochalcone
No. 90 No. 13
C00007929 External link 512 2',6'-Dihydroxy-4'-methoxydihydrochalcone
CHEMBL486009
No. 90 No. 13
C00007928 External link 512 2',4',6'-Trihydroxydihydrochalcone
/ 3-Phenyl-1-(2,4,6-trihydroxyphenyl)-1-propanone
CHEMBL503375
8 / 5 / 4 No. 90 No. 13
C00007233 External link 512 Isosalipurpol
/ Chalconaringenin
/ Naringenin chalcone
/ trans-2',4,4',6'-Tetrahydroxychalcone
/ (2E)- 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-2-Propen-1-one
CHEMBL338066
12 / 20 / 21 No. 92 No. 13
C00006933 External link 512 2',4',6'-Trihydroxychalcone
CHEMBL129371
2 / 0 / 3 No. 92 No. 13

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00007233 C00007928 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00007233 C00007928 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00006933 C00007233 0 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00006933 C00007233 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00007233 C00007928 4 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00007928 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00007233 0 / 1
P04062 Glucosylceramidase Enzyme C00007233 6 / 4
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00007233 7 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00007233 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007928 0 / 0
O00255 Menin Unclassified protein C00007233 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00007233 1 / 2
O15296 Arachidonate 15-lipoxygenase B Enzyme C00007233 0 / 0
Q96LD8 Sentrin-specific protease 8 Enzyme C00007928 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007928 1 / 1
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00007928 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (22)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)