PCIDB

Zanthoxylum armatum

Species

KNApSAcK Entry

Organism name Zanthoxylum armatum
Genus Zanthoxylum
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Zanthoxylum armatum
Linked NCBI taxonomy ID 67938
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (20)

Species Activity
Zanthoxylum armatum DC Antibacterial
Zanthoxylum armatum DC Antiseptic
Zanthoxylum armatum DC Aperitif
Zanthoxylum armatum DC Astringent
Zanthoxylum armatum DC Bitter
Zanthoxylum armatum DC Carminative
Zanthoxylum armatum DC Dentifrice
Zanthoxylum armatum DC Deodorant
Zanthoxylum armatum DC Depurative
Zanthoxylum armatum DC Diaphoretic
Zanthoxylum armatum DC Fungicide
Zanthoxylum armatum DC Hepatotonic
Zanthoxylum armatum DC Hypoglycemic
Zanthoxylum armatum DC Insectifuge
Zanthoxylum armatum DC Pectoral
Zanthoxylum armatum DC Piscicide
Zanthoxylum armatum DC Stimulant
Zanthoxylum armatum DC Stomachic
Zanthoxylum armatum DC Tonic
Zanthoxylum armatum DC Vermifuge

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001104 External link 512 Tambulin
CHEMBL478811
No. 3 No. 15
C00003737 External link 512 alpha-Amyrin
/ alpha-Amyrine
/ alpha-Amyrenol
No. 23 No. 51
C00003738 External link 512 beta-Amyrin
/ beta-Amirin
/ beta-Amyrine
/ beta-Amyrenol
C036380
0 / 4 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00007195 External link 512 (+)-Fargesin
CHEMBL462822
C058339
No. 38 No. 21
C00030244 External link 512 Fargesin
CHEMBL462822
No. 38 No. 21
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00035530 External link 512 Asarinin
C006637
No. 621 No. 21
C00027297 External link 512 Armatamide
No. 2200

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08047 Transcription factor Sp1 Unclassified protein C00003749 C00019308 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P06746 DNA polymerase beta Enzyme C00019308 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P00734 Prothrombin S1A C00019308 4 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (17)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

18 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D005157 Facial Pain C00003738
D006930 Hyperalgesia C00003738
D007249 Inflammation C00003738
D010146 Pain C00003738
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601