PCIDB

Zanthoxylum chalybeum

Species

KNApSAcK Entry

Organism name Zanthoxylum chalybeum
Genus Zanthoxylum
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Zanthoxylum
Linked NCBI taxonomy ID 67937
Linked level genus

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027159 External link 512 Depiline
/ Palmatine
/ Berbericinine
/ O,O-Dimethyldemethyleneberberine
CHEMBL206106
C005413
8 / 13 / 13 8 / 0 No. 155 No. 4
C00001885 External link 512 Escholin
/ Escholine
/ Thalictrin
/ Thalictrine
/ Magnoflorine
/ (+)-Magnoflorine
CHEMBL235428
C001670
No. 286 No. 4
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00025982 External link 512 Oblongine
/ (+)-Oblongine
CHEMBL457373
C081049
No. 896
C00025347 External link 512 Tembetarine
/ (+)-Tembetarine
C003383
No. 896

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 C00027159 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 C00027159 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 C00027159 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 C00027159 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 C00027159 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027159 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O75496 Geminin Unclassified protein C00000601 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00027159 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 0 / 0
P02545 Prelamin-A/C Unclassified protein C00027159 11 / 10
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00027159
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00027159
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00027159
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00027159
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00027159
3570 IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 interleukin 6 receptor C00027159
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00027159
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00027159

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (25)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601