Species

KNApSAcK Entry

Organism name Derris robusta
Genus Derris
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Derris robusta
Linked NCBI taxonomy ID 1225697
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009450 External link 512 5-Hydroxy-7-methoxyisoflavone
No. 3 No. 15
C00009479 External link 512 Derrugenin
/ 5,4'-Dihydroxy-7,2',5'-trimethoxyisoflavone
No. 3 No. 15
C00009484 External link 512 Robustigenin
/ 5-Hydroxy-7,2',4',5'-tetramethoxyisoflavone
No. 8 No. 15
C00009486 External link 512 Robustigenin methyl ether
/ 5,7,2',4',5'-Pentamethoxyisoflavone
No. 8 No. 15
C00009505 External link 512 Derrubone
/ 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone
CHEMBL412010
11 / 16 / 48 No. 15 No. 15
C00009496 External link 512 4'-O-Methylderrone
No. 24 No. 15
C00009493 External link 512 Derrone
CHEMBL393223
No. 24 No. 15
C00009503 External link 512 Robustone
CHEMBL252722
3 / 11 / 40 No. 24 No. 15
C00009508 External link 512 Robustone methyl ether
CHEMBL1403041
11 / 31 / 56 No. 24 No. 15
C00009504 External link 512 Alpinumisoflavone dimethyl ether
No. 24 No. 15
C00009466 External link 512 Derrustone
/ 5,7-Dimethoxy-3',4'-methylenedioxyisoflavone
CHEMBL252721
5 / 8 / 5 No. 27 No. 15
C00009788 External link 512 Methyl robustate
/ O-Methylrobustic acid
/ Robustic acid methyl ether
No. 377
C00009787 External link 512 Robustic acid
CHEMBL400777
C105206
11 / 26 / 54 No. 377
C00009790 External link 512 Robustin methyl ether
No. 377
C00009789 External link 512 Robustin
No. 377
C00009786 External link 512 Derrusnin
/ 4,5,7-Trimethoxy-3-(3,4-methylenedioxyphenyl)coumarin
CHEMBL1526572
10 / 32 / 57 No. 473

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00009466 C00009503 C00009505 C00009508 C00009786 C00009787 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00009466 C00009503 C00009505 C00009508 C00009786 C00009787 4 / 3
P04637 Cellular tumor antigen p53 Transcription Factor C00009503 C00009505 C00009508 C00009786 C00009787 7 / 37
P00352 Retinal dehydrogenase 1 Enzyme C00009466 C00009508 C00009786 C00009787 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00009466 C00009505 C00009508 C00009786 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00009505 C00009508 C00009786 2 / 2
Q16637 Survival motor neuron protein Unclassified protein C00009466 C00009508 C00009786 4 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00009508 C00009786 C00009787 3 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00009505 C00009508 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00009505 C00009787 1 / 2
O00255 Menin Unclassified protein C00009505 C00009787 2 / 5
P02545 Prelamin-A/C Unclassified protein C00009508 C00009786 11 / 10
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009508 C00009787 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00009505 0 / 0
P04062 Glucosylceramidase Enzyme C00009787 6 / 4
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00009787 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00009787 3 / 1
P06280 Alpha-galactosidase A Enzyme C00009786 1 / 1
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00009505 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00009505 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (44)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (68)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)