Species

KNApSAcK Entry

Organism name Wikstroemia viridiflora
Genus Wikstroemia
Family Thymelaeaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Wikstroemia
Linked NCBI taxonomy ID 142693
Linked level genus

Family

Family in NCBI taxonomy Thymelaeaceae
ID 39987

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00007203 External link 512 (+)-Wikstromol
/ (+)-Nortrachelogenin
CHEMBL453799
CHEMBL1483370
3 / 2 / 2 No. 223 No. 21
C00002463 External link 512 Daphnoretin
CHEMBL508494
C035316
14 / 11 / 10 No. 1906 No. 25

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00000609 C00007203 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000609 C00002463 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000609 C00002463 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00007203 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P06746 DNA polymerase beta Enzyme C00002463 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007203 1 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002463 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002463 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002463 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
O75496 Geminin Unclassified protein C00002463 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000609 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002463 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002463 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000609 1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002463 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002463 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002463 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002463 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002463 1 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
%606641 Body mass index; bmi P37231
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (21)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)