Ekebergia capensis
Species
KNApSAcK Entry
| Organism name | Ekebergia capensis |
|---|---|
| Genus | Ekebergia |
| Family | Meliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ekebergia capensis |
|---|---|
| Linked NCBI taxonomy ID | 124949 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Meliaceae |
|---|---|
| ID | 43707 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00019064
|
Oleanolic acid
/ Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
D009828
|
30 / 8 / 12 | 21 / 15 | No. 13 | No. 51 |
|
|
C00029494
|
epi-Oleanolic acid
/ 3-Epioleanolic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
30 / 8 / 12 | No. 13 | No. 51 |
|
||
|
C00038271
|
3-Oxo-11,13(18)-oleandien-28-oic acid
/ (-)-3-Oxo-11,13(18)-oleandien-28-oic acid |
CHEMBL55516
|
No. 13 | No. 51 |
|
|||
|
C00038236
|
3,11-Dioxoolean-12-en-28-oic acid
|
No. 13 | No. 51 |
|
||||
|
C00039087
|
Ekeberin A
/ (+)-Ekeberin A |
No. 101 | No. 52 |
|
||||
|
C00040073
|
Proceranolide
|
CHEMBL1081393
|
No. 102 |
|
||||
|
C00039764
|
Mexicanolide
|
CHEMBL1080142
CHEMBL1398245 CHEMBL1979074 |
3 / 2 / 4 | No. 102 |
|
|||
|
C00034297
|
Swietenolide
|
No. 102 |
|
|||||
|
C00039090
|
Ekeberin C2
|
No. 102 |
|
|||||
|
C00039091
|
Ekeberin C3
/ (-)-Ekeberin C3 |
No. 102 |
|
|||||
|
C00034777
|
7-Ketogedunin
/ 7-Deacetoxy-7-oxogedunin |
CHEMBL374788
CHEMBL452232 CHEMBL1512460 |
6 / 13 / 43 | No. 204 | No. 51 |
|
||
|
C00039089
|
Ekeberin C1
/ (-)-Ekeberin C1 |
CHEMBL484837
|
No. 204 | No. 51 |
|
|||
|
C00038274
|
4,6-Dimethoxy-5-methylcoumarin
|
No. 364 | No. 25 |
|
||||
|
C00039097
|
Ekersenin
/ Pereflorin |
No. 364 | No. 25 |
|
||||
|
C00049002
|
Methyl 3alpha-hydroxy-3-deoxyangolensate
|
CHEMBL1512719
|
4 / 0 / 1 | No. 1249 |
|
|||
|
C00039746
|
Melliferone
|
CHEMBL457498
|
No. 1519 |
|
||||
|
C00039096
|
Ekeberin D5
|
CHEMBL255487
|
No. 1875 |
|
||||
|
C00039092
|
Ekeberin D1
/ (+)-Ekeberin D1 |
No. 1875 |
|
|||||
|
C00038198
|
2,3,22,23-Tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene
|
CHEMBL429678
|
No. 1875 |
|
||||
|
C00038315
|
7-Acetylneotrichilenone
|
No. 2073 |
|
|||||
|
C00039093
|
Ekeberin D2
/ (+)-Ekeberin D2 |
No. 2822 |
|
|||||
|
C00039094
|
Ekeberin D3
/ (+)-Ekeberin D3 |
No. 2822 |
|
|||||
|
C00039095
|
Ekeberin D4
/ (+)-Ekeberin D4 |
CHEMBL255488
|
No. 2822 |
|
||||
|
C00038107
|
(-)-(Z)-Volkendousin
|
CHEMBL233040
|
No. 3702 |
|
||||
|
C00039088
|
Ekeberin B
/ (-)-Ekeberin B |
No. 3702 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00019064 C00029494 C00034777 C00039764 C00049002 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00034777 C00039764 C00049002 | 0 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00019064 C00029494 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00019064 C00029494 | 0 / 3 |
| P06746 | DNA polymerase beta | Enzyme | C00019064 C00029494 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00019064 C00029494 | 4 / 2 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00019064 C00029494 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00019064 C00029494 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00019064 C00029494 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00019064 C00029494 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00019064 C00029494 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00034777 C00039764 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00019064 C00029494 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00019064 C00029494 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00019064 C00029494 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00019064 C00029494 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00019064 C00029494 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00019064 C00029494 | 0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | C00019064 C00029494 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00019064 C00029494 | 2 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00019064 C00029494 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00019064 C00029494 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00019064 C00029494 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00019064 C00029494 | 0 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00019064 C00029494 | 0 / 0 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00019064 C00029494 | 1 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00019064 C00029494 | 1 / 4 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00019064 C00029494 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00019064 C00029494 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00019064 C00029494 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019064 C00029494 | 0 / 1 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00019064 C00029494 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00034777 C00049002 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00034777 | 4 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00049002 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00034777 | 7 / 37 |
21 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00019064
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00019064
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00019064
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00019064
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00019064
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00019064
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00019064
|
| 3065 | HDAC1, GON-10, HD1, RPD3, RPD3L1 | histone deacetylase 1 (EC:3.5.1.98) |
C00019064
|
| 3146 | HMGB1, HMG1, HMG3, SBP-1 | high mobility group box 1 |
C00019064
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00019064
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00019064
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00019064
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00019064
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00019064
|
| 5052 | PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 | peroxiredoxin 1 (EC:1.11.1.15) |
C00019064
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00019064
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00019064
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00019064
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00019064
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00019064
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00019064
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (21)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (51)
| KEGG | name | UniProt |
|---|---|---|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35228 (related) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002252 | Carbon Tetrachloride Poisoning |
C00019064
|
| D056486 | Drug-Induced Liver Injury |
C00019064
|
| D050171 | Dyslipidemias |
C00019064
|
| D018149 | Glucose Intolerance |
C00019064
|
| D006949 | Hyperlipidemias |
C00019064
|
| D007249 | Inflammation |
C00019064
|
| D007674 | Kidney Diseases |
C00019064
|
| D008103 | Liver Cirrhosis |
C00019064
|
| D008106 | Liver Cirrhosis, Experimental |
C00019064
|
| D008107 | Liver Diseases |
C00019064
|
| D017202 | Myocardial Ischemia |
C00019064
|
| D009369 | Neoplasms |
C00019064
|
| D009765 | Obesity |
C00019064
|
| D011041 | Poisoning |
C00019064
|
| D011230 | Precancerous Conditions |
C00019064
|