Species

KNApSAcK Entry

Organism name Chenopodium ambrosioides
Genus Chenopodium
Family Chenopodiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dysphania ambrosioides
Linked NCBI taxonomy ID 330163
Linked level species

Family

Family in NCBI taxonomy Amaranthaceae
ID 3563

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Natural Activity

List (40)

Species Activity
Chenopodium ambrosioides L. Abortifacient
Chenopodium ambrosioides L. Amebicide
Chenopodium ambrosioides L. Analgesic
Chenopodium ambrosioides L. Antiasthmatic
Chenopodium ambrosioides L. Antibacterial
Chenopodium ambrosioides L. Antifeedant
Chenopodium ambrosioides L. Antimalarial
Chenopodium ambrosioides L. Antipyretic
Chenopodium ambrosioides L. Antiseptic
Chenopodium ambrosioides L. Antispasmodic
Chenopodium ambrosioides L. Antitussive
Chenopodium ambrosioides L. Antiulcer
Chenopodium ambrosioides L. Apifuge
Chenopodium ambrosioides L. Ascaricide
Chenopodium ambrosioides L. Carcinogenic
Chenopodium ambrosioides L. Cardiodepressant
Chenopodium ambrosioides L. Cardiotonic
Chenopodium ambrosioides L. Carminative
Chenopodium ambrosioides L. Contraceptive
Chenopodium ambrosioides L. Decongestant
Chenopodium ambrosioides L. Diaphoretic
Chenopodium ambrosioides L. Diuretic
Chenopodium ambrosioides L. Emmenagogue
Chenopodium ambrosioides L. Fungicide
Chenopodium ambrosioides L. Hypotensive
Chenopodium ambrosioides L. Insecticide
Chenopodium ambrosioides L. Lactagogue
Chenopodium ambrosioides L. Laxative
Chenopodium ambrosioides L. Myorelaxant
Chenopodium ambrosioides L. Narcotic
Chenopodium ambrosioides L. Nervine
Chenopodium ambrosioides L. Panacea
Chenopodium ambrosioides L. Paralytic
Chenopodium ambrosioides L. Poison
Chenopodium ambrosioides L. Protisticide
Chenopodium ambrosioides L. Respirastimulant
Chenopodium ambrosioides L. Stimulant
Chenopodium ambrosioides L. Stomachic
Chenopodium ambrosioides L. Tonic
Chenopodium ambrosioides L. Vermifuge

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00013694 External link 512 Nepetin 7-rhamnoside-3'-xyloside
No. 1 No. 15
C00005195 External link 512 Kaempferol 3-rhamnoside-4'-xyloside
No. 1 No. 15
C00005187 External link 512 Kaempferol 3-rhamnoside-7-xyloside
No. 1 No. 15
C00004515 External link 512 7,3',4'-Trihydroxy-6-methoxyflavone 7-rhamnoside-3'-xyloside
No. 1 No. 15
C00003890 External link 512 Jaceosidin
/ 5,7,4'-Trihydroxy-6,3'-dimethoxyflavone
CHEMBL487601
C477508
1 / 0 / 0 No. 3 No. 15
C00003516 External link 512 Echinocystic acid
CHEMBL230128
CHEMBL464557
CHEMBL1395408
CHEMBL1559201
C022999
5 / 0 / 1 8 / 2 No. 13 No. 51
C00000836 External link 512 cis-Thujone
/ (+)-Thujone
/ beta-Thujone
CHEMBL1444078
2 / 3 / 2 No. 1161 No. 35
C00000804 External link 512 (-)-3-Isothujone
/ (-)-alpha-Thujone
CHEMBL1444078
2 / 3 / 2 No. 1161 No. 35
C00000831 External link 512 (+)-trans-Sabinol
C052984
No. 1343 No. 35
C00011043 External link 512 (-)-Pinocarvone
No. 1561 No. 35
C00000828 External link 512 (+)-Sabinone
No. 1561 No. 35
C00000819 External link 512 (+)-Camphor
CHEMBL504760
CHEMBL1316134
D002164
99 / 56 / 51 5 / 3 No. 1921 No. 35

Human Protein / Gene in interactions

104 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor C00000804 C00000836 3 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000819 C00003516 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000819 C00003516 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000804 C00000836 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000819 C00003516 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000819 0 / 0
P08246 Neutrophil elastase S1A C00000819 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000819 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000819 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000819 0 / 0
P29466 Caspase-1 C14 C00000819 0 / 0
P17252 Protein kinase C alpha type Alpha C00000819 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000819 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000819 2 / 2
P02545 Prelamin-A/C Unclassified protein C00000819 11 / 10
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000819 1 / 0
P00918 Carbonic anhydrase 2 Lyase C00000819 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000819 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000819 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000819 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000819 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000819 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000819 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000819 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000819 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000819 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000819 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000819 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000819 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000819 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00000819 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000819 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000819 0 / 3
P41145 Kappa-type opioid receptor Opioid receptor C00000819 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000819 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000819 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000819 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000819 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000819 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000819 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000819 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000819 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000819 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000819 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000819 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000819 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000819 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000819 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000819 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000819 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000819 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000819 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000819 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000819 0 / 0
P08311 Cathepsin G S1A C00000819 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000819 1 / 0
P03956 Interstitial collagenase M10A C00000819 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000819 0 / 0
P30559 Oxytocin receptor Vasopressin and oxytocin receptor C00003516 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003516 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000819 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000819 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000819 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000819 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000819 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000819 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000819 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000819 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000819 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000819 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000819 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00000819 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000819 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000819 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000819 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000819 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00000819 1 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000819 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000819 2 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000819 0 / 0
P03372 Estrogen receptor NR3A1 C00000819 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000819 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000819 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000819 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000819 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000819 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000819 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000819 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000819 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000819 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000819 1 / 1
Q8NET8 Transient receptor potential cation channel subfamily V member 3 Unclassified protein C00000819 1 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000819 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000819 4 / 3
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000819 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000819 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000819 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000819 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000819 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000819 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000819 0 / 0
P59538 Taste receptor type 2 member 31 Taste receptor (taste family GPCR) C00003890 0 / 0
O00255 Menin Unclassified protein C00000819 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000819 1 / 2

13 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00003516
637 BID, FP497 BH3 interacting domain death agonist C00003516
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003516
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003516
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00003516
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003516
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00003516
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00003516
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00000819
2554 GABRA1, ECA4, EJM, EJM5 gamma-aminobutyric acid (GABA) A receptor, alpha 1 C00000819
2561 GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 C00000819
2566 GABRG2, CAE2, ECA2, GEFSP3 gamma-aminobutyric acid (GABA) A receptor, gamma 2 C00000819
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000819

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (59)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#614594 Palmoplantar keratoderma, mutilating, with periorificial keratotic plaques Q8NET8
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (53)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D017202 Myocardial Ischemia C00003516
D009369 Neoplasms C00003516
D003371 Cough C00000819
D004487 Edema C00000819
D012640 Seizures C00000819