Species

KNApSAcK Entry

Organism name Helleborus caucasicus
Genus Helleborus
Family Ranunculaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Helleborus
Linked NCBI taxonomy ID 46995
Linked level genus

Family

Family in NCBI taxonomy Ranunculaceae
ID 3440

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00033702 External link 512 Caucasicoside B
/ (-)-Caucasicoside B
No. 17 No. 11
C00033703 External link 512 Caucasicoside C
/ (-)-Caucasicoside C
No. 17 No. 11
C00033904 External link 512 Hellebosaponin B
No. 21 No. 11
C00033903 External link 512 Hellebosaponin A
/ (-)-Hellebosaponin A
CHEMBL504992
No. 21 No. 11
C00033543 External link 512 20-Hydroxyecdysone
CHEMBL224128
CHEMBL490151
CHEMBL477132
CHEMBL1707235
CHEMBL2087148
CHEMBL2087156
CHEMBL2087157
CHEMBL2354392
6 / 2 / 1 No. 58 No. 11
C00034279 External link 512 Spirosta-5,25(27)-diene-1beta,3beta,11alpha-triol
No. 171 No. 11
C00033905 External link 512 Hellebrigenin
/ 3beta,5beta,14beta-Trihydroxy-19-oxo-bufa-20,22-dienolide 3-O-beta-D-glucopyranoside
CHEMBL2068960
C001330
No. 434 No. 57
C00033755 External link 512 Deglucohellebrin
CHEMBL443199
CHEMBL1169625
CHEMBL1169626
No. 698 No. 57
C00033704 External link 512 Caucasicoside D
No. 1126
C00033701 External link 512 Caucasicoside A
/ (-)-Caucasicoside A
No. 8444

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08183 Multidrug resistance protein 1 drug C00033543 1 / 0
O75496 Geminin Unclassified protein C00033543 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00033543 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00033543 0 / 0
O00167 Eyes absent homolog 2 Enzyme C00033543 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00033543 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#612244 Inflammatory bowel disease 13; ibd13 P08183

KEGG DISEASE (1)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)