Species

KNApSAcK Entry

Organism name Dalbergia sissoides
Genus Dalbergia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dalbergia
Linked NCBI taxonomy ID 53862
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010124 External link 512 Tectorigenin 7-O-gentiobioside
No. 1 No. 15
C00000977 External link 512 Liquiritigenin
CHEMBL252642
CHEMBL271939
C083152
5 / 4 / 4 1 / 1 No. 25 No. 14
C00002519 External link 512 Dalbergin
/ 6-Hydroxy-7-methoxy-4-phenylcoumarin
CHEMBL1829658
No. 54 No. 17
C00019537 External link 512 6-Ketodehydroamorphigenin
/ 6-Oxo-11-hydroxy-2,3-dimethoxy-5'-(1-hydroxymethylethenyl)furan[2',3':9,8]-6a,12a-didehydrorotenone
No. 236 No. 15
C00010252 External link 512 (S)-4-Methoxydalbergione
CHEMBL255297
CHEMBL466581
CHEMBL1554531
18 / 23 / 57 No. 1327 No. 18

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000977 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00010252 7 / 37
P14780 Matrix metalloproteinase-9 M10A C00000977 2 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00010252 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00010252 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00010252 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00010252 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00000977 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00010252 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000977 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00010252 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00010252 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00010252 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00010252 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00010252 4 / 3
P05412 Transcription factor AP-1 Transcription Factor C00000977 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00010252 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00010252 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00010252 1 / 1
O00255 Menin Unclassified protein C00010252 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00010252 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00010252 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00010252 1 / 4

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1831 TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP TSC22 domain family, member 3 C00000977

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009120 Muscle Cramp C00000977