Species

KNApSAcK Entry

Organism name Adiantum spp.
Genus Adiantum
Family Pteridaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Adiantum
Linked NCBI taxonomy ID 13817
Linked level genus

Family

Family in NCBI taxonomy Pteridaceae
ID 13819

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Euphyllophyta
ID 78536

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006620 External link 512 Gesnerin
No. 2 No. 15
C00005376 External link 512 Miquelianin
/ Quercetin 3-O-beta-D-glucuronide
CHEMBL520546
CHEMBL1506682
23 / 30 / 21 No. 2 No. 15
C00003784 External link 512 Rhodoxanthin
C038054
No. 26 No. 59
C00000983 External link 512 Naringin
CHEMBL451532
CHEMBL451512
CHEMBL1742953
CHEMBL1970019
C005274
18 / 12 / 6 12 / 4 No. 48 No. 14
C00006610 External link 512 Apigeninidin
CHEMBL1197890
C104027
No. 71 No. 15

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein C00000983 C00005376 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000983 C00005376 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005376 3 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005376 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000983 0 / 0
P06746 DNA polymerase beta Enzyme C00005376 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005376 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005376 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005376 11 / 10
P08183 Multidrug resistance protein 1 drug C00000983 1 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005376 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005376 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005376 0 / 0
O75496 Geminin Unclassified protein C00000983 0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein C00000983 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000983 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00005376 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00005376 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005376 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000983 1 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00000983 1 / 2
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000983 3 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000983 1 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000983 2 / 2
P10696 Alkaline phosphatase, placental-like Enzyme C00005376 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005376 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005376 0 / 0
P61088 Ubiquitin-conjugating enzyme E2 N Enzyme C00000983 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005376 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000983 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00005376 4 / 3
Q9Y251 Heparanase Enzyme C00000983 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005376 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005376 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000983 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000983 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005376 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005376 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000983 1 / 1

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000983
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000983
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000983
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000983
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000983
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000983
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000983
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000983
8772 FADD, MORT1 Fas (TNFRSF6)-associated via death domain C00000983
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000983
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000983
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000983

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (42)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (26)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00213 Hypophosphatasia P05186 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00000983
D056486 Drug-Induced Liver Injury C00000983
D009203 Myocardial Infarction C00000983
D002583 Uterine Cervical Neoplasms C00000983