Species

KNApSAcK Entry

Organism name Hedyotis dichotoma
Genus Hedyotis
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hedyotis
Linked NCBI taxonomy ID 58416
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00049916 External link 512 1,4-Dihydroxy-2,3-dimethoxyanthraquinone
No. 41 No. 62
C00029633 External link 512 Ursolic acid
/ Acetylursolic acid
CHEMBL55086
CHEMBL410525
4 / 2 / 2 No. 177
C00049934 External link 512 2,3-Dimethoxy-9-hydroxy-1,4-anthraquinone
No. 1285

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00001059 C00029633 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 C00029633 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 C00029633 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001059 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001059 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001059 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
P39748 Flap endonuclease 1 Enzyme C00001059 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00001059 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00029633 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 0 / 0
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001059 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001059 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001059 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001059 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 1 / 0
O00255 Menin Unclassified protein C00001059 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001059 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#114500 Colorectal cancer; crc Q14191
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (21)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)