Species

KNApSAcK Entry

Organism name Acacia cyanophylla
Genus Acacia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Acacia saligna
Linked NCBI taxonomy ID 420411
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005548 External link 512 Narcissin
/ Isorhamnetin 3-O-rutinoside
CHEMBL84174
CHEMBL258394
CHEMBL1711509
CHEMBL2165403
C031062
7 / 1 / 2 No. 1 No. 15
C00001071 External link 512 Myricetin
CHEMBL164
C040015
78 / 70 / 56 39 / 2 No. 3 No. 15
C00008817 External link 512 Gallocatechin
/ (+)-Gallocatechin
/ (+)-Gallocatechol
/ (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14
C00002647 External link 512 Gallic acid
CHEMBL288114
D005707
42 / 53 / 68 52 / 16 No. 817 No. 81

Human Protein / Gene in interactions

120 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001071 C00002647 C00008817 0 / 3
P11473 Vitamin D3 receptor NR1I1 C00001071 C00002647 C00008817 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001071 C00002647 C00008817 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001071 C00002647 C00008817 3 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001071 C00002647 C00008817 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001071 C00002647 C00008817 2 / 2
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001071 C00002647 C00008817 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001071 C00002647 C00008817 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001071 C00002647 C00008817 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001071 C00002647 C00008817 4 / 3
Q9UNA4 DNA polymerase iota Enzyme C00001071 C00005548 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001071 C00008817 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001071 C00005548 0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001071 C00008817 0 / 0
P03372 Estrogen receptor NR3A1 C00002647 C00005548 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001071 C00002647 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001071 C00008817 0 / 1
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002647 C00008817 2 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001071 C00008817 0 / 0
P15121 Aldose reductase Enzyme C00001071 C00002647 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001071 C00008817 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001071 C00002647 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001071 C00008817 1 / 1
Q02880 DNA topoisomerase 2-beta Isomerase C00001071 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001071 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002647 1 / 2
P02768 Serum albumin Secreted protein C00008817 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00001071 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001071 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00002647 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001071 0 / 1
P07237 Protein disulfide-isomerase Enzyme C00005548 0 / 0
P54132 Bloom syndrome protein Enzyme C00001071 1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00001071 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001071 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00001071 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00001071 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00001071 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00008817 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00008817 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002647 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00001071 1 / 1
Q9Y3R4 Sialidase-2 Enzyme C00001071 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001071 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002647 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001071 0 / 0
P16581 E-selectin Adhesion C00002647 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002647 1 / 2
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00001071 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001071 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001071 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002647 0 / 0
O75496 Geminin Unclassified protein C00005548 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00008817 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00008817 0 / 0
P10145 Interleukin-8 Secreted protein C00002647 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002647 0 / 0
Q14790 Caspase-8 C14 C00001071 2 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005548 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001071 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00001071 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00001071 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001071 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001071 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001071 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001071 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002647 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002647 0 / 1
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00001071 5 / 4
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001071 2 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001071 4 / 4
P06276 Cholinesterase Hydrolase C00001071 0 / 0
P04745 Alpha-amylase 1 Enzyme C00001071 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001071 2 / 0
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00001071 9 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00002647 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00001071 0 / 1
P56817 Beta-secretase 1 A1A C00008817 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001071 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002647 0 / 1
P43166 Carbonic anhydrase 7 Lyase C00002647 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001071 1 / 1
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002647 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00001071 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005548 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00008817 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002647 0 / 0
P12821 Angiotensin-converting enzyme M2 C00002647 4 / 2
P22303 Acetylcholinesterase Hydrolase C00001071 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00008817 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002647 11 / 10
P04062 Glucosylceramidase Enzyme C00001071 6 / 4
P14151 L-selectin Adhesion C00002647 0 / 0
P16109 P-selectin Adhesion C00002647 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001071 1 / 1
P06746 DNA polymerase beta Enzyme C00001071 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002647 3 / 0
Q15046 Lysine--tRNA ligase Enzyme C00001071 2 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00001071 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001071 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002647 5 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00001071 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001071 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002647 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00002647 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00001071 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00002647 1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00008817 0 / 7
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001071 2 / 0
Q99700 Ataxin-2 Unclassified protein C00001071 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001071 0 / 0
P40225 Thrombopoietin Unclassified protein C00001071 1 / 1
P31941 DNA dC->dU-editing enzyme APOBEC-3A Enzyme C00001071 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002647 4 / 1
O00255 Menin Unclassified protein C00001071 2 / 5
P04637 Cellular tumor antigen p53 Transcription Factor C00002647 7 / 37
P33527 Multidrug resistance-associated protein 1 drugs C00001071 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001071 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001071 2 / 1
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00001071 0 / 0

81 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00001071 C00002647
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001071 C00002647
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001071 C00002647
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001071 C00002647
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001071 C00002647
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001071 C00002647
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001071 C00002647
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001071 C00002647
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001071 C00002647
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001071 C00002647
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002647
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001071
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00001071
891 CCNB1, CCNB cyclin B1 C00001071
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001071
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001071
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00001071
54583 EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) C00001071
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00001071
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00001071
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00001071
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00001071
847 CAT catalase (EC:1.11.1.6) C00001071
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00001071
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001071
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00001071
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00001071
8505 PARG, PARG99 poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) C00001071
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001071
8000 PSCA, PRO232 prostate stem cell antigen C00001071
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001071
397 ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2 Rho GDP dissociation inhibitor (GDI) beta C00001071
23411 SIRT1, SIR2L1 sirtuin 1 C00001071
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00001071
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00001071
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00001071
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00001071
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00001071
7161 TP73, P73 tumor protein p73 C00001071
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002647
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002647
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002647
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00002647
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00002647
545 ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 ataxia telangiectasia and Rad3 related (EC:2.7.11.1) C00002647
613 BCR, ALL, BCR1, CML, D22S11, D22S662, PHL breakpoint cluster region (EC:2.7.11.1) C00002647
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002647
898 CCNE1, CCNE cyclin E1 C00002647
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00002647
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002647
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00002647
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00002647
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002647
2551 GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 GA binding protein transcription factor, alpha subunit 60kDa C00002647
2885 GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 growth factor receptor-bound protein 2 C00002647
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00002647
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002647
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002647
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002647
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002647
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00001071
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002647
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002647
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002647
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002647
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002647
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00002647
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00002647
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002647
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00002647
19412 C00002647
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00002647
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00002647
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00002647
9252 RPS6KA5, MSK1, MSPK1, RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) C00002647
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002647
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002647
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002647
7224 TRPC5, TRP5 transient receptor potential cation channel, subfamily C, member 5 C00002647
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002647
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002647

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (109)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P42336
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#607271 Caspase 8 deficiency Q14790
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P42336
Q14191
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#114550 Hepatocellular carcinoma P08581
P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#147050 Ige responsiveness, atopic; iger Q13093
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
Q14790
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P42336
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#267430 Renal tubular dysgenesis; rtd P12821
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P12821
P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (104)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
P08581 (related)
P10415 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P42336 (related)
H00028 Choriocarcinoma P04637 (related)
P10415 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00030 Cervical cancer P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00108 Autoimmune lymphoproliferative syndromes (ALPS) Q14790 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009203 Myocardial Infarction C00001071
C00002647
D006949 Hyperlipidemias C00002647
D003921 Diabetes Mellitus, Experimental C00002647
D050171 Dyslipidemias C00002647
D005234 Fatty Liver C00002647
D018149 Glucose Intolerance C00002647
D006937 Hypercholesterolemia C00002647
D006943 Hyperglycemia C00002647
D005909 Glioblastoma C00001071
D015228 Hypertriglyceridemia C00002647
D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive C00002647
D008546 Melanoma, Experimental C00002647
D009069 Movement Disorders C00002647
D009361 Neoplasm Invasiveness C00002647
D009362 Neoplasm Metastasis C00002647
D012516 Osteosarcoma C00002647
D010182 Pancreatic Diseases C00002647