| Organism name | Acacia cyanophylla |
|---|---|
| Genus | Acacia |
| Family | Fabaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Acacia saligna |
|---|---|
| Linked NCBI taxonomy ID | 420411 |
| Linked level | species |
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00005548
|
Narcissin
/ Isorhamnetin 3-O-rutinoside |
CHEMBL84174
CHEMBL258394 CHEMBL1711509 CHEMBL2165403 |
C031062
|
7 / 1 / 2 | No. 1 | No. 15 |
|
|
|
C00001071
|
Myricetin
|
CHEMBL164
|
C040015
|
78 / 70 / 56 | 39 / 2 | No. 3 | No. 15 |
|
|
C00008817
|
Gallocatechin
/ (+)-Gallocatechin / (+)-Gallocatechol / (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol |
CHEMBL47386
CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845 |
26 / 17 / 29 | No. 52 | No. 14 |
|
||
|
C00002647
|
Gallic acid
|
CHEMBL288114
|
D005707
|
42 / 53 / 68 | 52 / 16 | No. 817 | No. 81 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001071 C00002647 C00008817 | 0 / 3 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001071 C00002647 C00008817 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001071 C00002647 C00008817 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001071 C00002647 C00008817 | 3 / 3 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001071 C00002647 C00008817 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001071 C00002647 C00008817 | 2 / 2 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001071 C00002647 C00008817 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001071 C00002647 C00008817 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001071 C00002647 C00008817 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001071 C00002647 C00008817 | 4 / 3 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001071 C00005548 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001071 C00008817 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001071 C00005548 | 0 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001071 C00008817 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002647 C00005548 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001071 C00002647 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001071 C00008817 | 0 / 1 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002647 C00008817 | 2 / 3 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001071 C00008817 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00001071 C00002647 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001071 C00008817 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001071 C00002647 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001071 C00008817 | 1 / 1 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00001071 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001071 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002647 | 1 / 2 |
| P02768 | Serum albumin | Secreted protein | C00008817 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00001071 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00001071 | 0 / 0 |
| P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00002647 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001071 | 0 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005548 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001071 | 1 / 2 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00001071 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001071 | 1 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001071 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00001071 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00001071 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00008817 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002647 | 0 / 0 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00001071 | 1 / 1 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00001071 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001071 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002647 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001071 | 0 / 0 |
| P16581 | E-selectin | Adhesion | C00002647 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002647 | 1 / 2 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00001071 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001071 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001071 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002647 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00005548 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00008817 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002647 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002647 | 0 / 0 |
| Q14790 | Caspase-8 | C14 | C00001071 | 2 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00005548 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001071 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00001071 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00001071 | 3 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001071 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001071 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001071 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00001071 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002647 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002647 | 0 / 1 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00001071 | 5 / 4 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001071 | 2 / 2 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00001071 | 4 / 4 |
| P06276 | Cholinesterase | Hydrolase | C00001071 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00001071 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001071 | 2 / 0 |
| P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Enzyme | C00001071 | 9 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002647 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00001071 | 0 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00008817 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001071 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002647 | 0 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002647 | 0 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001071 | 1 / 1 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002647 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00001071 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00005548 | 0 / 0 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00008817 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002647 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002647 | 4 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001071 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00008817 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002647 | 11 / 10 |
| P04062 | Glucosylceramidase | Enzyme | C00001071 | 6 / 4 |
| P14151 | L-selectin | Adhesion | C00002647 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00002647 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001071 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001071 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002647 | 3 / 0 |
| Q15046 | Lysine--tRNA ligase | Enzyme | C00001071 | 2 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001071 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001071 | 1 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002647 | 5 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001071 | 0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00001071 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002647 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002647 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00001071 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002647 | 1 / 1 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00008817 | 0 / 7 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001071 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001071 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001071 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00001071 | 1 / 1 |
| P31941 | DNA dC->dU-editing enzyme APOBEC-3A | Enzyme | C00001071 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002647 | 4 / 1 |
| O00255 | Menin | Unclassified protein | C00001071 | 2 / 5 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002647 | 7 / 37 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00001071 | 0 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00001071 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001071 | 2 / 1 |
| Q9HCT0 | Fibroblast growth factor 22 | Unclassified protein | C00001071 | 0 / 0 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001071
C00002647
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001071
C00002647
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001071
C00002647
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001071
C00002647
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001071
C00002647
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001071
C00002647
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00001071
C00002647
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00001071
C00002647
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00001071
C00002647
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001071
C00002647
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002647
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00001071
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00001071
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00001071
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001071
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001071
|
| 1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00001071
|
| 54583 | EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 | egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) |
C00001071
|
| 2203 | FBP1, FBP | fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) |
C00001071
|
| 3082 | HGF, DFNB39, F-TCF, HGFB, HPTA, SF | hepatocyte growth factor (hepapoietin A; scatter factor) |
C00001071
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00001071
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00001071
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001071
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00001071
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001071
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00001071
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00001071
|
| 8505 | PARG, PARG99 | poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) |
C00001071
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001071
|
| 8000 | PSCA, PRO232 | prostate stem cell antigen |
C00001071
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001071
|
| 397 | ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2 | Rho GDP dissociation inhibitor (GDI) beta |
C00001071
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00001071
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00001071
|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00001071
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00001071
|
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 |
C00001071
|
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 |
C00001071
|
| 7161 | TP73, P73 | tumor protein p73 |
C00001071
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002647
|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002647
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002647
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00002647
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00002647
|
| 545 | ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 | ataxia telangiectasia and Rad3 related (EC:2.7.11.1) |
C00002647
|
| 613 | BCR, ALL, BCR1, CML, D22S11, D22S662, PHL | breakpoint cluster region (EC:2.7.11.1) |
C00002647
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002647
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002647
|
| 998 | CDC42, CDC42Hs, G25K | cell division cycle 42 |
C00002647
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002647
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00002647
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00002647
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002647
|
| 2551 | GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 | GA binding protein transcription factor, alpha subunit 60kDa |
C00002647
|
| 2885 | GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 | growth factor receptor-bound protein 2 |
C00002647
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002647
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002647
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00002647
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00002647
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002647
|
| 1031 | CDKN2C, INK4C, p18, p18-INK4C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
C00001071
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002647
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002647
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002647
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002647
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00002647
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00002647
|
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00002647
|
| 5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00002647
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00002647
|
| 19412 |
C00002647
|
||
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00002647
|
| 388 | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 | ras homolog family member B |
C00002647
|
| 6195 | RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) |
C00002647
|
| 9252 | RPS6KA5, MSK1, MSPK1, RLPK | ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) |
C00002647
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002647
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002647
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002647
|
| 7224 | TRPC5, TRP5 | transient receptor potential cation channel, subfamily C, member 5 |
C00002647
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002647
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002647
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P42336
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #607271 | Caspase 8 deficiency |
Q14790
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #613641 | Charcot-marie-tooth disease, recessive intermediate b; cmtrib |
Q15046
|
| #114500 | Colorectal cancer; crc |
P18054
P42336 Q14191 |
| #612918 | Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi |
P42336
|
| #615108 | Cowden syndrome 5; cws5 |
P42336
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #613916 | Deafness, autosomal recessive 89; dfnb89 |
Q15046
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #114550 | Hepatocellular carcinoma |
P08581
P42336 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
| #182000 | Keratosis, seborrheic |
P42336
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
Q14790 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #602501 | Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap |
P42336
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
P42336
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P42336
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P12821
P16109 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) Q15046 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) P28907 (marker) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
P08581 (related) P10415 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P42336 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
P10415 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00108 | Autoimmune lymphoproliferative syndromes (ALPS) |
Q14790
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D009203 | Myocardial Infarction |
C00001071
C00002647 |
| D006949 | Hyperlipidemias |
C00002647
|
| D003921 | Diabetes Mellitus, Experimental |
C00002647
|
| D050171 | Dyslipidemias |
C00002647
|
| D005234 | Fatty Liver |
C00002647
|
| D018149 | Glucose Intolerance |
C00002647
|
| D006937 | Hypercholesterolemia |
C00002647
|
| D006943 | Hyperglycemia |
C00002647
|
| D005909 | Glioblastoma |
C00001071
|
| D015228 | Hypertriglyceridemia |
C00002647
|
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
C00002647
|
| D008546 | Melanoma, Experimental |
C00002647
|
| D009069 | Movement Disorders |
C00002647
|
| D009361 | Neoplasm Invasiveness |
C00002647
|
| D009362 | Neoplasm Metastasis |
C00002647
|
| D012516 | Osteosarcoma |
C00002647
|
| D010182 | Pancreatic Diseases |
C00002647
|