Species

KNApSAcK Entry

Organism name Isodon oresbius
Genus Isodon
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Isodon
Linked NCBI taxonomy ID 204130
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001110 External link 512 Vitexin
/ Apigenin 8-C-glucoside
/ 8-D-Glucosyl-4',5,7-trihydroxyflavone
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00014119 External link 512 Oresbiusin
/ 6,7,8-Trihydroxy-5-methoxyflavanone
No. 25 No. 14
C00035598 External link 512 Effusanin E
No. 83
C00035517 External link 512 Adenolin B
No. 83
C00003424 External link 512 Enmein
CHEMBL453801
C007594
No. 241 No. 41
C00035709 External link 512 Oreskaurin A
/ (-)-Oreskaurin A
No. 241 No. 41
C00035769 External link 512 Trichorabdal A
C090066
No. 241 No. 41
C00035600 External link 512 Enmelol
CHEMBL434181
No. 339
C00035710 External link 512 Oreskaurin B
/ (-)-Oreskaurin B
No. 339
C00035711 External link 512 Oreskaurin C
/ (-)-Oreskaurin C
No. 339
C00035744 External link 512 Sodoponin
No. 339
C00035768 External link 512 Trichokaurin
No. 339
C00035601 External link 512 Enmenin
No. 339

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001110 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001110 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001110 0 / 1
O75496 Geminin Unclassified protein C00001110 0 / 0
P15121 Aldose reductase Enzyme C00001110 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001110 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001110 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001110 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001110 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001110 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001110 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001110 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001110 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001110 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001110 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001110 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (8)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)