Species

KNApSAcK Entry

Organism name Capparis leucophylla
Genus Capparis
Family Capparaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Capparis
Linked NCBI taxonomy ID 13394
Linked level genus

Family

Family in NCBI taxonomy Capparaceae
ID 301453

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00002074 External link 512 Stachydrine
CHEMBL394450
CHEMBL1456892
CHEMBL1986864
10 / 8 / 12 No. 2627 No. 1
C00007619 External link 512 Citric acid
CHEMBL1261
D019343
101 / 48 / 38 15 / 7 No. 7422
C00001198 External link 512 Oxalic acid
CHEMBL146755
D019815
2 / 0 / 0 1 / 6 No. 7540

Human Protein / Gene in interactions

116 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002074 C00003672 C00007619 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002074 C00003672 C00007619 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002074 C00003672 C00007619 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002074 C00003672 C00007619 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002074 C00003672 C00007619 1 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00001198 C00007619 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00001198 C00007619 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 C00007619 1 / 1
P00734 Prothrombin S1A C00003672 C00019308 4 / 2
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 C00019308 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00019308 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 C00019308 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002074 C00003672 3 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00019308 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00007619 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00007619 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00007619 2 / 2
P41235 Hepatocyte nuclear factor 4-alpha Unclassified protein C00007619 3 / 1
P29466 Caspase-1 C14 C00007619 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00007619 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00007619 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00007619 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00007619 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00007619 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00007619 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00007619 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00007619 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00007619 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00007619 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00007619 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00007619 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00007619 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00007619 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00007619 0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00007619 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00007619 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00007619 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00007619 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00007619 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00007619 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00007619 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00007619 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00007619 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00007619 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00007619 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00007619 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00007619 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00007619 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002074 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00007619 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00007619 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00007619 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00007619 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00007619 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00007619 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00007619 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00007619 0 / 0
P17252 Protein kinase C alpha type Alpha C00007619 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00007619 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00007619 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00007619 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00007619 0 / 0
P08311 Cathepsin G S1A C00007619 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00007619 1 / 0
P03956 Interstitial collagenase M10A C00007619 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00007619 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002074 0 / 0
P08246 Neutrophil elastase S1A C00007619 2 / 1
P04150 Glucocorticoid receptor NR3C1 C00007619 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00007619 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00007619 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00007619 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00007619 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007619 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00007619 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00007619 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00007619 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00007619 2 / 2
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00007619 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00007619 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00007619 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00007619 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00007619 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00007619 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00007619 2 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007619 0 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00007619 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00007619 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00007619 1 / 0
P22303 Acetylcholinesterase Hydrolase C00007619 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00007619 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00007619 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00007619 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00007619 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00007619 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00007619 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00007619 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
O60240 Perilipin-1 Unclassified protein C00007619 1 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00007619 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00007619 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00007619 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00007619 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00007619 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00007619 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00007619 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00007619 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00007619 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00007619 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
O00255 Menin Unclassified protein C00002074 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002074 1 / 2
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein C00007619 1 / 2

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
50 ACO2, ACONM, ICRD aconitase 2, mitochondrial (EC:4.2.1.3) C00007619
581 BAX, BCL2L4 BCL2-associated X protein C00007619
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00007619
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00007619
100506742 CASP12, CASP-12, CASP12P1 caspase 12 (gene/pseudogene) C00007619
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00007619
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00007619
2746 GLUD1, GDH, GDH1, GLUD glutamate dehydrogenase 1 (EC:1.4.1.3) C00007619
25818 KLK5, KLK-L2, KLKL2, SCTE kallikrein-related peptidase 5 C00007619
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00007619
9058 SLC13A2, NADC1, NaCT, NaDC-1, SDCT1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 C00007619
7015 TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT telomerase reverse transcriptase (EC:2.7.7.49) C00007619
7018 TF, PRO1557, PRO2086, TFQTL1 transferrin C00007619
7442 TRPV1, VR1 transient receptor potential cation channel, subfamily V, member 1 C00007619
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00007619
26762 HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 hepatitis A virus cellular receptor 1 C00001198

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (67)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#218030 Apparent mineralocorticoid excess; ame P80365
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#609338 Carotid intimal medial thickness 1 P37231
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#125853 Diabetes mellitus, noninsulin-dependent; niddm P41235
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613877 Lipodystrophy, familial partial, type 4; fpld4 O60240
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#125850 Maturity-onset diabetes of the young, type 1; mody1 P41235
#606391 Maturity-onset diabetes of the young; mody P41235
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (53)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
Q9C0B1 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00410 Maturity onset diabetes of the young (MODY) P41235 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D002418 Cattle Diseases C00007619
D003371 Cough C00007619
D004716 Endometritis C00007619
D017202 Myocardial Ischemia C00007619
D011645 Puerperal Infection C00007619
D053201 Urinary Bladder, Overactive C00007619
D014652 Vascular Diseases C00007619
D058186 Acute Kidney Injury C00001198
D006959 Hyperoxaluria C00001198
D006960 Hyperoxaluria, Primary C00001198
D009397 Nephrocalcinosis C00001198
D053040 Nephrolithiasis C00001198
D051437 Renal Insufficiency C00001198