PCIDB

Aspergillus insuetus

Species

KNApSAcK Entry

Organism name Aspergillus insuetus
Genus Aspergillus
Family Trichocomaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aspergillus insuetus
Linked NCBI taxonomy ID 469274
Linked level species

Family

Family in NCBI taxonomy Aspergillaceae
ID 1131492

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68
C00048191 External link 512 Terretonin E
/ (-)-Terretonin E
CHEMBL558895
No. 1901
C00048192 External link 512 Terretonin F
/ (-)-Terretonin F
CHEMBL561116
No. 1901
C00019674 External link 512 Uridine
CHEMBL68846
CHEMBL100259
CHEMBL265701
CHEMBL608294
CHEMBL609651
CHEMBL1092065
CHEMBL2093066
D014529
5 / 0 / 3 7 / 15 No. 2366
C00011252 External link 512 Aurantiamine
CHEMBL570312
CHEMBL1579523
8 / 3 / 5 No. 3555

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00001224 C00011252 C00019674 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00011252 C00019674 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00011252 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001224 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00011252 1 / 4
P02545 Prelamin-A/C Unclassified protein C00001224 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001224 3 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001224 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001224 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001224 0 / 0
P27708 CAD protein Enzyme C00019674 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001224 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 0 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 0 / 0
Q9HA47 Uridine-cytidine kinase 1 Enzyme C00019674 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00011252 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001224 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019674 0 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 5 / 3
P13726 Tissue factor Membrane receptor C00001224 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00001224 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00001224 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001224 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001224 2 / 2
P03372 Estrogen receptor NR3A1 C00001224 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001224 0 / 1
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
Q99700 Ataxin-2 Unclassified protein C00011252 1 / 1
P10275 Androgen receptor NR3C4 C00001224 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001224 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00011252 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001224 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00011252 1 / 0

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00019674
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00019674
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00019674
9154 SLC28A1, CNT1, HCNT1 solute carrier family 28 (concentrative nucleoside transporter), member 1 C00019674
9153 SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 solute carrier family 28 (concentrative nucleoside transporter), member 2 C00019674
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019674
3177 SLC29A2, DER12, ENT2, HNP36 solute carrier family 29 (equilibrative nucleoside transporter), member 2 C00019674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#208900 Ataxia-telangiectasia; at Q13315
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601665 Obesity P37231
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (35)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

15 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000015 Abnormalities, Multiple C00019674
D000749 Anemia, Megaloblastic C00019674
D001919 Bradycardia C00019674
D002375 Catalepsy C00019674
D004342 Drug Hypersensitivity C00019674
D056486 Drug-Induced Liver Injury C00019674
D064420 Drug-Related Side Effects and Adverse Reactions C00019674
D005234 Fatty Liver C00019674
D007022 Hypotension C00019674
D028361 Mitochondrial Diseases C00019674
C538525 Mitochondrial encephalopathy C00019674
D017240 Mitochondrial Myopathies C00019674
D010523 Peripheral Nervous System Diseases C00019674
D011565 Psoriasis C00019674
D019956 Stereotypic Movement Disorder C00019674