Echium vulgare
Species
KNApSAcK Entry
| Organism name | Echium vulgare |
|---|---|
| Genus | Echium |
| Family | Boraginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Echium vulgare |
|---|---|
| Linked NCBI taxonomy ID | 34253 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Boraginaceae |
|---|---|
| ID | 21571 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007247
|
Linolenic acid
/ alpha-Linolenic acid / (Z,Z,Z)-Octadeca-9,12,15-trienoic acid |
D017962
|
22 / 5 |
|
||||
|
C00001226
|
gamma-Linolenic acid
/ 6(Z),9(Z),12(Z)-Octadecatrienoic acid |
CHEMBL464982
|
D017965
|
17 / 8 / 5 | 42 / 0 | No. 300 | No. 68 |
|
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 | No. 367 | No. 68 |
|
||
|
C00002400
|
Lithospermic acid
/ Lithosperminc acid |
CHEMBL518243
|
C046833
|
0 / 2 | No. 494 |
|
||
|
C00002088
|
Heliosupine
|
No. 623 | No. 2 |
|
||||
|
C00026188
|
Echihumiline
|
No. 623 | No. 2 |
|
||||
|
C00026174
|
7-Tigloylretronecine
|
No. 1265 | No. 2 |
|
||||
|
C00026176
|
9-Angelylretronecine
/ 9-Angeloylretronecine / 9-O-Angelylretronecine |
No. 1265 | No. 2 |
|
||||
|
C00026177
|
9-Senecioylretronecine
/ O9-Senecioylretronecine / 9-O-Senecioylretronecine |
No. 1265 | No. 2 |
|
||||
|
C00026178
|
9-Tiglylretronecine
/ 9-Tigloylretronecine / Retronecine 9-(trans-2-methylcrotonate) |
No. 1265 | No. 2 |
|
||||
|
C00026169
|
7-Angelylretronecine
/ 7-Angeloylretronecine / O-7-Angelylretronecine / Retronecine 7-(2-methylcrotonate) |
No. 1265 | No. 2 |
|
Human Protein / Gene in interactions
42 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001226 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001224 C00001226 | 0 / 0 |
| P13726 | Tissue factor | Membrane receptor | C00001224 C00001226 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 C00001226 | 0 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001224 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001224 | 3 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 | 0 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00001226 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001226 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001224 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001224 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001226 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001226 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001226 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001226 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001226 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001224 | 5 / 3 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001224 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001224 | 2 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00001224 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001224 | 0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001226 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001224 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001226 | 2 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001226 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001224 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001226 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001226 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001226 | 2 / 1 |
59 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00001226
C00007247
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001226
C00007247
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00001226
C00007247
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001226
C00007247
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00001226
C00007247
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00001226
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007247
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00007247
|
| 3992 | FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12 | fatty acid desaturase 1 (EC:1.14.19.-) |
C00007247
|
| 8647 | ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
C00007247
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007247
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00007247
|
| 3827 | KNG1, BDK, BK, KNG | kininogen 1 |
C00007247
|
| 9971 | NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 | nuclear receptor subfamily 1, group H, member 4 |
C00007247
|
| 1591 | CYP24A1, CP24, CYP24, HCAI, P450-CC24 | cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) |
C00007247
|
| 100136658 |
C00007247
|
||
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00007247
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00007247
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00007247
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00007247
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00007247
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00001226
|
| 1109 | AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA | aldo-keto reductase family 1, member C4 (EC:1.1.1.225 1.1.1.357) |
C00001226
|
| 350 | APOH, B2G1, B2GP1, BG | apolipoprotein H (beta-2-glycoprotein I) |
C00001226
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00001226
|
| 427 | ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME | N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) |
C00001226
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001226
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00001226
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00001226
|
| 7122 | CLDN5, AWAL, BEC1, CPETRL1, TMVCF | claudin 5 |
C00001226
|
| 1211 | CLTA, LCA | clathrin, light chain A |
C00001226
|
| 2495 | FTH1, FHC, FTH, FTHL6, PIG15, PLIF | ferritin, heavy polypeptide 1 (EC:1.16.3.1) |
C00001226
|
| 2869 | GRK5, GPRK5 | G protein-coupled receptor kinase 5 (EC:2.7.11.16) |
C00001226
|
| 3074 | HEXB, ENC-1AS | hexosaminidase B (beta polypeptide) (EC:3.2.1.52) |
C00001226
|
| 8334 | HIST1H2AC, H2A/l, H2AFL, dJ221C16.4 | histone cluster 1, H2ac |
C00001226
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00001226
|
| 3726 | JUNB, AP-1 | jun B proto-oncogene |
C00001226
|
| 8942 | KYNU | kynureninase (EC:3.7.1.3) |
C00001226
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001226
|
| 4320 | MMP11, SL-3, ST3, STMY3 | matrix metallopeptidase 11 (stromelysin 3) (EC:3.4.24.-) |
C00001226
|
| 4495 | MT1G, MT1, MT1K | metallothionein 1G |
C00001226
|
| 4500 | MT1L, MT1, MT1R, MTF | metallothionein 1L (gene/pseudogene) |
C00001226
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00001226
|
| 100506658 | OCLN, BLCPMG | occludin (EC:2.1.1.67) |
C00001226
|
| 5111 | PCNA | proliferating cell nuclear antigen |
C00001226
|
| 9124 | PDLIM1, CLIM1, CLP-36, CLP36, hCLIM1 | PDZ and LIM domain 1 |
C00001226
|
| 123 | PLIN2, ADFP, ADRP | perilipin 2 |
C00001226
|
| 22949 | PTGR1, LTB4DH, PGR1, ZADH3 | prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) |
C00001226
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00001226
|
| 6502 | SKP2, FBL1, FBXL1, FLB1, p45 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
C00001226
|
| 6520 | SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE | solute carrier family 3 (amino acid transporter heavy chain), member 2 |
C00001226
|
| 6767 | ST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
C00001226
|
| 7033 | TFF3, ITF, P1B, TFI | trefoil factor 3 (intestinal) |
C00001226
|
| 7082 | TJP1, ZO-1 | tight junction protein 1 |
C00001226
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001226
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00001226
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00001226
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (38)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00002400
C00007247 |
| D003866 | Depressive Disorder |
C00007247
|
| D001930 | Brain Injuries |
C00007247
|
| D015210 | Arthritis, Gouty |
C00002400
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00007247
|
| D009422 | Nervous System Diseases |
C00007247
|