Species

KNApSAcK Entry

Organism name Phaseolus multiflorus
Genus Phaseolus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Phaseolus coccineus
Linked NCBI taxonomy ID 3886
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006636 External link 512 Pelargonidin 3-sophoroside
No. 1 No. 15
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000005 External link 512 GA5
/ Gibberellin A5
No. 40 No. 41
C00000006 External link 512 GA6
/ Gibberellin A6
No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00000017 External link 512 GA17
/ Gibberellin A17
No. 187 No. 41
C00003170 External link 512 Phaseic acid
No. 2610 No. 38
C00001424 External link 512 Norepinephrine
/ L-Noradrenaline
/ (-)-Norepinephrine
CHEMBL432
CHEMBL18824
CHEMBL1437
CHEMBL2311152
D009638
50 / 33 / 35 36 / 90 No. 3197

Human Protein / Gene in interactions

57 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00000003 C00001424 11 / 10
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 C00001424 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 C00001424 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001424 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001424 0 / 0
Q99489 D-aspartate oxidase Enzyme C00001424 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 1 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001424 3 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001424 0 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001424 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001424 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 0 / 1
P14920 D-amino-acid oxidase Enzyme C00001424 0 / 0
P54132 Bloom syndrome protein Enzyme C00001424 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001424 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00001424 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00001424 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001424 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001424 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001424 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 2 / 0
O75496 Geminin Unclassified protein C00000003 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001424 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001424 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001424 0 / 0
Q9GZT4 Serine racemase Enzyme C00001424 0 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter C00001424 0 / 0
P50224 Sulfotransferase 1A3/1A4 Enzyme C00001424 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001424 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001424 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001424 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001424 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001424 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001424 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 1 / 1
Q9Y2I1 Nischarin Other cytosolic protein C00001424 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001424 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001424 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001424 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001424 0 / 0
P10275 Androgen receptor NR3C4 C00000003 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001424 1 / 1
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001424 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001424 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001424 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001424 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001424 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001424 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001424 1 / 1
O00255 Menin Unclassified protein C00001424 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001424 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001424 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001424 1 / 4
O75751 Solute carrier family 22 member 3 Unclassified protein C00001424 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001424 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001424 0 / 0

36 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
148 ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR adrenoceptor alpha 1A C00001424
147 ADRA1B, ADRA1, ALPHA1BAR adrenoceptor alpha 1B C00001424
146 ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2 adrenoceptor alpha 1D C00001424
150 ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A C00001424
151 ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR adrenoceptor alpha 2B C00001424
152 ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR adrenoceptor alpha 2C C00001424
153 ADRB1, ADRB1R, B1AR, BETA1AR, RHR adrenoceptor beta 1 C00001424
154 ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR adrenoceptor beta 2, surface C00001424
155 ADRB3, BETA3AR adrenoceptor beta 3 C00001424
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001424
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001424
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00001424
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001424
1813 DRD2, D2DR, D2R dopamine receptor D2 C00001424
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00001424
2778 GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH GNAS complex locus C00001424
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001424
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001424
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001424
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001424
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001424
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00001424
4879 NPPB, BNP natriuretic peptide B C00001424
4852 NPY, PYY4 neuropeptide Y C00001424
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001424
6279 S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 S100 calcium binding protein A8 C00001424
6280 S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14 S100 calcium binding protein A9 C00001424
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00001424
6570 SLC18A1, CGAT, VAT1, VMAT1 solute carrier family 18 (vesicular monoamine transporter), member 1 C00001424
6571 SLC18A2, SVAT, SVMT, VAT2, VMAT2 solute carrier family 18 (vesicular monoamine transporter), member 2 C00001424
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001424
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001424
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001424
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001424
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001424
7391 USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 upstream transcription factor 1 C00001424

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#103780 Alcohol dependence P14416
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#604715 Orthostatic intolerance P23975
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (41)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

90 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00001424
D000647 Amnesia C00001424
D019969 Amphetamine-Related Disorders C00001424
D017542 Aneurysm, Ruptured C00001424
D000860 Anoxia C00001424
D001002 Anuria C00001424
D001008 Anxiety Disorders C00001424
D001145 Arrhythmias, Cardiac C00001424
D001237 Asphyxia C00001424
D001321 Autistic Disorder C00001424
D001766 Blindness C00001424
D001919 Bradycardia C00001424
D002545 Brain Ischemia C00001424
D002037 Bundle-Branch Block C00001424
D002100 Cachexia C00001424
D002303 Cardiac Output, Low C00001424
D006332 Cardiomegaly C00001424
D009202 Cardiomyopathies C00001424
D002375 Catalepsy C00001424
D002543 Cerebral Hemorrhage C00001424
D019970 Cocaine-Related Disorders C00001424
D003922 Diabetes Mellitus, Type 1 C00001424
D004409 Dyskinesia, Drug-Induced C00001424
D004421 Dystonia C00001424
D004827 Epilepsy C00001424
D005901 Glaucoma C00001424
D005921 Glomerulonephritis C00001424
D005923 Glomerulosclerosis, Focal Segmental C00001424
D006261 Headache C00001424
D006323 Heart Arrest C00001424
D006331 Heart Diseases C00001424
D006333 Heart Failure C00001424
D006470 Hemorrhage C00001424
D006930 Hyperalgesia C00001424
D006935 Hypercapnia C00001424
D006940 Hyperemia C00001424
D006973 Hypertension C00001424
D006974 Hypertension, Malignant C00001424
D006976 Hypertension, Pulmonary C00001424
D006984 Hypertrophy C00001424
D017379 Hypertrophy, Left Ventricular C00001424
D007008 Hypokalemia C00001424
D007022 Hypotension C00001424
D007024 Hypotension, Orthostatic C00001424
D007035 Hypothermia C00001424
D007511 Ischemia C00001424
D007674 Kidney Diseases C00001424
D008113 Liver Neoplasms C00001424
D008114 Liver Neoplasms, Experimental C00001424
D009203 Myocardial Infarction C00001424
D017202 Myocardial Ischemia C00001424
D015428 Myocardial Reperfusion Injury C00001424
D009336 Necrosis C00001424
D009410 Nerve Degeneration C00001424
D009798 Ocular Hypertension C00001424
D009846 Oliguria C00001424
D009901 Optic Nerve Diseases C00001424
D010146 Pain C00001424
D010243 Paralysis C00001424
D010554 Personality Disorders C00001424
D011183 Postoperative Complications C00001424
D011249 Pregnancy Complications, Cardiovascular C00001424
D011297 Prenatal Exposure Delayed Effects C00001424
D011507 Proteinuria C00001424
D011605 Psychoses, Substance-Induced C00001424
D029424 Pulmonary Disease, Chronic Obstructive C00001424
D051437 Renal Insufficiency C00001424
D012120 Respiration Disorders C00001424
D012131 Respiratory Insufficiency C00001424
D012164 Retinal Diseases C00001424
D012206 Rhabdomyolysis C00001424
D012640 Seizures C00001424
D018805 Sepsis C00001424
D012769 Shock C00001424
D012770 Shock, Cardiogenic C00001424
D012771 Shock, Hemorrhagic C00001424
D012772 Shock, Septic C00001424
D013035 Spasm C00001424
D013226 Status Epilepticus C00001424
D013274 Stomach Neoplasms C00001424
D013345 Subarachnoid Hemorrhage C00001424
D013375 Substance Withdrawal Syndrome C00001424
D013610 Tachycardia C00001424
D013616 Tachycardia, Sinus C00001424
D017180 Tachycardia, Ventricular C00001424
D014511 Uremia C00001424
D056987 Vasoplegia C00001424
D018754 Ventricular Dysfunction C00001424
D018487 Ventricular Dysfunction, Left C00001424
D014693 Ventricular Fibrillation C00001424