Delphinium corymbosum Rgl.
Species
KNApSAcK Entry
| Organism name | Delphinium corymbosum Rgl. |
|---|---|
| Genus | Delphinium |
| Family | Ranunculaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Delphinium |
|---|---|
| Linked NCBI taxonomy ID | 46246 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001653
|
Lycoctonine
/ (+)-Lycoctonine |
CHEMBL517003
CHEMBL1242718 CHEMBL1303310 CHEMBL1975737 CHEMBL2356607 |
C093992
|
3 / 10 / 7 | No. 31 | No. 10 |
|
|
|
C00001631
|
Delcorine
|
CHEMBL1396858
CHEMBL1742074 CHEMBL1868972 CHEMBL2112852 |
8 / 4 / 3 | No. 31 | No. 10 |
|
||
|
C00001615
|
Anthranoyllycoctonine
|
CHEMBL359227
CHEMBL451362 CHEMBL1499239 CHEMBL1968141 |
11 / 33 / 28 | No. 166 | No. 10 |
|
||
|
C00028578
|
Methyllycaconitine
|
CHEMBL223494
CHEMBL387362 CHEMBL510275 CHEMBL1412391 CHEMBL1592980 CHEMBL1620703 CHEMBL1869403 CHEMBL2094019 |
C054634
|
21 / 12 / 8 | 15 / 7 | No. 166 | No. 10 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001631 C00028578 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001631 C00028578 | 2 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001631 C00028578 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001631 C00028578 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001631 C00028578 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001631 C00028578 | 0 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001615 C00001653 | 7 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001615 | 1 / 2 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00028578 | 1 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00028578 | 1 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00001615 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001653 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001615 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001615 | 2 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001615 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00001631 | 0 / 0 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00028578 | 0 / 0 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00028578 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00028578 | 1 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00028578 | 0 / 0 |
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | C00028578 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00028578 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001615 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001631 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001615 | 11 / 10 |
| P04062 | Glucosylceramidase | Enzyme | C00001615 | 6 / 4 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001615 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001615 | 2 / 5 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | C00028578 | 1 / 1 |
| Q8WXA8 | 5-hydroxytryptamine receptor 3C | NS | C00028578 | 0 / 0 |
| Q70Z44 | 5-hydroxytryptamine receptor 3D | NS | C00028578 | 0 / 0 |
| O95264 | 5-hydroxytryptamine receptor 3B | NS | C00028578 | 0 / 0 |
| A5X5Y0 | 5-hydroxytryptamine receptor 3E | NS | C00028578 | 0 / 0 |
| Q9UGM1 | Neuronal acetylcholine receptor subunit alpha-9 | CHRN alpha | C00028578 | 0 / 0 |
| Q9GZZ6 | Neuronal acetylcholine receptor subunit alpha-10 | CHRN alpha | C00028578 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001653 | 1 / 1 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00028578
|
| 627 | BDNF, ANON2, BULN2 | brain-derived neurotrophic factor |
C00028578
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00028578
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00028578
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00028578
|
| 1621 | DBH, DBM | dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) |
C00028578
|
| 3674 | ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
C00028578
|
| 3690 | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
C00028578
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00028578
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00028578
|
| 4915 | NTRK2, GP145-TrkB, TRKB, trk-B | neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) |
C00028578
|
| 6774 | STAT3, APRF, HIES | signal transducer and activator of transcription 3 (acute-phase response factor) |
C00028578
|
| 7054 | TH, DYT14, DYT5b, TYH | tyrosine hydroxylase (EC:1.14.16.2) |
C00028578
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00028578
|
| 7538 | ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36 | ZFP36 ring finger protein |
C00028578
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (48)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #149400 | Hyperekplexia, hereditary 1; hkpx1 |
P23415
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (40)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H00769 | Hyperekplexia |
P23415
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|