Alstonia angustifolia
Species
KNApSAcK Entry
| Organism name | Alstonia angustifolia |
|---|---|
| Genus | Alstonia |
| Family | Apocynaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Alstonia |
|---|---|
| Linked NCBI taxonomy ID | 52821 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Apocynaceae |
|---|---|
| ID | 4056 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (37)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00027061
|
Lagumicine
/ 19-Dehydrocompactinervine |
No. 61 | No. 4 |
|
||||
|
C00027079
|
Alstovine
|
No. 61 | No. 4 |
|
||||
|
C00025912
|
Isositsirikine
/ 16R,19E-Isositsirikine |
CHEMBL453018
|
C038932
|
No. 260 | No. 4 |
|
||
|
C00027077
|
Sitsirikine
|
No. 260 | No. 4 |
|
||||
|
C00027069
|
Lochnerine
/ 10-O-Methylsarpagine / 10-Methoxynormacusine B |
CHEMBL484153
|
No. 490 | No. 4 |
|
|||
|
C00025193
|
Tombozin
/ Tombozine / Vellosiminol / Normacusine B / 10-Deoxysarpagine |
CHEMBL477697
|
No. 490 | No. 4 |
|
|||
|
C00027047
|
10-Methoxyaffinisine
|
No. 490 | No. 4 |
|
||||
|
C00027070
|
Alstoumerine
|
No. 490 | No. 4 |
|
||||
|
C00001676
|
Affinisine
|
No. 490 | No. 4 |
|
||||
|
C00024335
|
(-)-Vincamajine
/ N-Methylquebrachidine |
CHEMBL607365
|
2 / 2 / 2 | No. 507 |
|
|||
|
C00024281
|
Quebrachidine
/ (+)-Quebrachidine |
C010318
|
No. 507 |
|
||||
|
C00027076
|
10-Methoxyvincamajine
/ (-)-10-Methoxyvincamajine |
No. 507 |
|
|||||
|
C00027701
|
19,20-Didehydro-10-methoxytalcarpine
|
No. 1205 |
|
|||||
|
C00035694
|
N(4)-Demethylalstonerinal
|
No. 1205 |
|
|||||
|
C00027065
|
Alstonerine
|
CHEMBL606749
|
2 / 2 / 2 | No. 1205 |
|
|||
|
C00027045
|
Alstonerinal
/ (-)-Alstonerinal |
CHEMBL2332138
|
No. 1205 |
|
||||
|
C00027066
|
Alstophylline
|
No. 1205 |
|
|||||
|
C00035756
|
Strictamine
|
C022062
|
No. 1217 |
|
||||
|
C00035458
|
11-Hydroxy-strictamine
|
No. 1217 |
|
|||||
|
C00027074
|
11-Methoxystrictamine
|
No. 1217 |
|
|||||
|
C00027050
|
Isoalstonisine
|
CHEMBL592449
|
2 / 2 / 2 | No. 1224 |
|
|||
|
C00027052
|
Alstonoxine A
|
No. 1224 |
|
|||||
|
C00027093
|
Alstonoxine B
|
No. 1224 |
|
|||||
|
C00027051
|
Macrogentine
|
No. 1224 |
|
|||||
|
C00027054
|
Alstofoline
|
No. 1224 |
|
|||||
|
C00027064
|
Alstonal
|
No. 1224 |
|
|||||
|
C00026670
|
Talcarpine
/ (-)-Talcarpine |
CHEMBL2332140
|
No. 1242 |
|
||||
|
C00027068
|
N-Methyl-4,21-secotalpinine
/ N(4)-Methyl-N(4),21-secotalpinine / N(4)-Methyl-N(4),21-seco-talpinine |
CHEMBL2332141
|
No. 1242 |
|
||||
|
C00027078
|
11-Methoxyakuammicine
|
No. 1800 | No. 4 |
|
||||
|
C00025960
|
Norfluorocurarine
/ C-Norcurarine III / nor-C-Fluorocurarine / (-)-Norfluorocurarine |
CHEMBL1395099
|
5 / 6 / 11 | No. 1800 | No. 4 |
|
||
|
C00027071
|
Cathafoline
/ (-)-1,2-Dihydro-N-methylstrictamine |
No. 1909 |
|
|||||
|
C00035456
|
10-Methoxycathafoline
|
CHEMBL2332143
|
No. 1909 |
|
||||
|
C00027072
|
Cathafoline N(4)-oxide
|
No. 1909 |
|
|||||
|
C00027075
|
Vincorine
|
No. 1909 |
|
|||||
|
C00027059
|
Affinisine oxindole
|
No. 2061 |
|
|||||
|
C00029221
|
Villalstonine
/ (+)-Villalstonine |
C009663
|
No. 3718 |
|
||||
|
C00026667
|
Alstolactone
|
No. 8542 |
|
Human Protein / Gene in interactions
7 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00024335 C00027050 C00027065 | 1 / 1 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00024335 C00027050 C00027065 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025960 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00025960 | 2 / 3 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025960 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00025960 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025960 | 1 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|