Species

KNApSAcK Entry

Organism name Tabernaemontana coffeoides Boj.
Genus Tabernaemontana
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tabernaemontana
Linked NCBI taxonomy ID 52860
Linked level genus

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (34)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00024488 External link 512 14,15-Dihydroxyvincadifformine
No. 61 No. 4
C00024457 External link 512 Lochnericine
/ (-)-Lochnericine
CHEMBL2011514
No. 61 No. 4
C00024458 External link 512 Hazuntine
/ (-)-Hazuntine
/ (-)-Lochnerinine
No. 61 No. 4
C00025887 External link 512 Hazuntinin
/ Hazuntinine
CHEMBL525066
No. 61 No. 4
C00024508 External link 512 3-Oxotabersonine
/ 8-Oxotabersonine
/ (-)-3-Oxotabersonine
No. 61 No. 4
C00025698 External link 512 19,20-Dihydrotabernamine
/ (20'S)-19',20'-Dihydrotabernamine
No. 217
C00025693 External link 512 (19R)-19-Hydroxytabernaelegantine A
No. 217
C00026054 External link 512 Tabernaelegantine A
CHEMBL1518309
No. 217
C00025207 External link 512 Reserpilin
/ Elliptamine
/ Reserpiline
/ (-)-Reserpiline
CHEMBL1622689
No. 246 No. 4
C00025183 External link 512 Isoreserpiline
/ Neoreserpiline
CHEMBL1622689
No. 246 No. 4
C00025916 External link 512 Isovoacangine
/ (-)-Isovoacangine
CHEMBL360427
CHEMBL1713663
5 / 3 / 1 No. 250 No. 4
C00025223 External link 512 Voacangine
/ (-)-Voacangine
/ Carbomethoxyibogaine
CHEMBL182120
C012098
No. 250 No. 4
C00025727 External link 512 Epiheyneanin
/ Epiheyneanine
/ 20-Epiheyneanine
/ 19-Epiheyneanine
/ (-)-19-Epiheyneanine
CHEMBL182405
CHEMBL361284
No. 250 No. 4
C00025173 External link 512 Heyneanin
/ Heyneanine
/ (-)-Heyneanine
CHEMBL182405
CHEMBL361284
No. 250 No. 4
C00026009 External link 512 Pericyclivine
/ (+)-Pericyclivine
/ Deformoakuammidine
C031498
No. 260 No. 4
C00025226 External link 512 Voacarpine
No. 260 No. 4
C00026041 External link 512 Stemmadenine
CHEMBL486212
C046117
No. 260 No. 4
C00026073 External link 512 Vallesamine
/ (+)-Vallesamine
/ 19,20-(E)-Vallesamine
No. 260 No. 4
C00025197 External link 512 Polyneuridine
/ Normacusine A
/ (-)-Polyneuridine
CHEMBL454572
CHEMBL498115
No. 260 No. 4
C00026059 External link 512 Serpinin
/ Serpinine
/ Tetraphyllicin
/ (+)-Tetraphyllicine
No. 279
C00025193 External link 512 Tombozin
/ Tombozine
/ Vellosiminol
/ Normacusine B
/ 10-Deoxysarpagine
CHEMBL477697
No. 490 No. 4
C00024619 External link 512 Voaphyllin
/ Conoflorin
/ Conoflorine
/ Voaphylline
/ (+)-Conoflorine
/ (+)-Voaphylline
CHEMBL496674
No. 828
C00025941 External link 512 Methuenine
CHEMBL520722
CHEMBL487204
C042118
No. 1292
C00025909 External link 512 Isomethuenine
CHEMBL520722
CHEMBL487204
No. 1292
C00025759 External link 512 6-Oxosilicine
No. 1428
C00025758 External link 512 6-Oxomethuenine
CHEMBL487403
No. 1428
C00025756 External link 512 6-Oxo-16-episilicine
No. 1428
C00026032 External link 512 Silicine
/ Decarbomethoxy-20-epiervatamine
/ 16-Decarbomethoxy-20-epiervatamine
/ 16-Demethoxycarbonyl-20-epiervatamine
No. 1428
C00025736 External link 512 20-Episilicine
No. 1428
C00001689 External link 512 Apparicine
/ (-)-Apparicine
CHEMBL285671
1 / 0 / 1 No. 1476
C00026055 External link 512 20-Epidregamine
/ Tabernaemontanin
/ Tabernaemontanine
/ (-)-Tabernemontanine
/ (-)-Tabernaemontanine
CHEMBL564301
CHEMBL1480853
CHEMBL1594801
CHEMBL1967575
CHEMBL2006905
9 / 2 / 3 No. 1771
C00025859 External link 512 Dregamine
/ (-)-Dregamine
/ 20-Epitabernemontanine
CHEMBL564301
CHEMBL1480853
CHEMBL1594801
CHEMBL1967575
CHEMBL2006905
9 / 2 / 3 No. 1771
C00026077 External link 512 Vincanidine
No. 1800 No. 4
C00025743 External link 512 Dihydroellipticine
/ 3,14-Dihydroellipticine
No. 8198

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025859 C00026055 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025859 C00026055 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00025859 C00026055 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00025859 C00026055 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025859 C00026055 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025859 C00026055 0 / 1
P51151 Ras-related protein Rab-9A Unclassified protein C00025859 C00026055 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025859 C00026055 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025859 C00026055 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025916 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001689 0 / 1
O75496 Geminin Unclassified protein C00025916 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025916 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025916 2 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00025916 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613795 Loeys-dietz syndrome, type 3; lds3 P84022

KEGG DISEASE (5)

KEGG name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)